Abstract
Many viruses initiate their infection processes by interacting with cells in tight epithelial layers, which line the surfaces of the body that are exposed to the external environment. The cell biology of this virus-cell interaction may be one of the important factors which play a role in viral pathogenesis. The individual cells in epithelial layers are tightly connected by junctional complexes, which form a barrier to diffusion of molecules across the cell layer and also divide the cell surface into two distinct plasma membrane domains: the apical domain which faces the lumen, and the basolateral domain which faces the interior of the body. In addition to their role in providing a permeability barrier, the junctional complexes restrict the lateral diffusion of membrane proteins and lipids between the apical and basolateral plasma membrane domains. As a result of the restricted diffusion of membrane components as well as the differential targeting of distinct sets of lipids and proteins to apical vs basolateral membranes, the epithelial cells in such tissues are highly polarized, with each plasma membrane domain having a distinct lipid and protein composition (reviewed by Rodriguez-Boulan and Nelson 1989).
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Compans, R.W. (1995). Virus Entry and Release in Polarized Epithelial Cells. In: Oldstone, M.B.A., Vitković, L. (eds) HIV and Dementia. Current Topics in Microbiology and Immunology, vol 202. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79657-9_14
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DOI: https://doi.org/10.1007/978-3-642-79657-9_14
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