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From Ultradian Biochemical Oscillations to Circadian Rhythms

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Membranes and Circadian Rythms

Summary

The goal of this chapter is to examine some of the best-known examples of ultradian biochemical oscillations and to draw a comparison between these periodic phenomena and circadian rhythms. Successively considered in the first part of the chapter are (i) glycolytic oscillations observed in yeast and muscle, (ii) the periodic synthesis of cyclic AMP (cAMP) signals which govern aggregation and differentiation in the cellular slime mold Dictyostelium discoideum, and (iii) the mitotic oscillator that controls the early cell division cycles in amphibian embryos. For each of these biochemical rhythms, the salient experimental aspects and the insights provided by theoretical models are summarized in turn. The second part of the chapter is devoted to the mechanism of circadian rhythms in Drosophila. A theoretical model for circadian oscillations in the period protein (PER) is presented. This minimal model is based on multiple phosphorylation of PER and on the negative feedback exerted by PER on the transcription of the period gene. Parallels are drawn between the mechanisms underlying ultradian biochemical oscillations and the mechanism that governs the circadian, periodic variation of PER in Drosophila.

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Authors and Affiliations

  1. Unité de Chronobiologie Théorique, Service de Chimie Physique, Université Libre de Bruxelles, Campus Plaine, C.P. 231, B-1050, Brussels, Belgium

    Albert Goldbeter (Faculté des Sciences)

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  1. Albert Goldbeter
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Editors and Affiliations

  1. Département de Biologie Moleculaire, Université Libre de Bruxelles, 46, avenue des Ortolans, 1170, Bruxelles, Belgium

    Therese Vanden Driessche

  2. Pool de Physique, Université Libre de Bruxelles, Campus Plaine C.P. 222 50, avenue F.D. Roosevelt, 1050, Bruxelles, Belgium

    Jean-Luc Guisset (Faculté de Sciences) (Faculté de Sciences)

  3. Chimie Generale I, Université Libre de Bruxelles, Campus Solbosh C.P. 160/18 50, avenue F.D. Roosevelt, 1050, Bruxelles, Belgium

    Ghislaine M. Petiau-de Vries (Faculté de Médecine) (Faculté de Médecine)

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Goldbeter, A. (1996). From Ultradian Biochemical Oscillations to Circadian Rhythms. In: Vanden Driessche, T., Guisset, JL., Petiau-de Vries, G.M. (eds) Membranes and Circadian Rythms. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79903-7_4

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