Abstract
Solutes in the cochlear fluids are in a highly dynamic state. The rates of turnover of some ions in endolymph have been quantified using radiotracers (Konishi et al, 1978; Sterkers et al, 1982). These studies established entry half times for K+, for example, of 55 to 60 mins. However, the basic physiologic mechanisms underlying cochlear fluids turnover have been difficult to establish. The most fundamental question in this regard, is whether the fluids are secreted in volume and whether longitudinal fluid flow represents a significant fluid turnover component. In the studies summarized here, longitudinal cochlear fluid movements have been quantified in endolymphatic and perilymphatic scalae under a variety of experimental conditions.
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References
Guild SR (1927) The circulation of the endolymph. Am J Anat 39:57–81
Konishi T, Hamrick PE, Walsh PJ (1978) Ion transport in the guinea pig cochlea. Acta Otolaryngol (Stockh) 86, 22–34
Lundquist PG, Kimura R, Wersall J (1964) Experiments in endolymph circulation. Acta Otolaryngol (Stockh) 188: 194–201
Ohyama K, Salt AN, Thalmann R (1988) Volume flow rate of perilymph in the guinea pigcochlea. Hear Res 35:119–130
Salt AN, Thalmann R, Marcus DC, Bohne BA (1986) Direct measurement of longitudinal endolymph flow rate in the guinea pig cochlea. Hear Res 23:141–151
Salt AN, Thalmann R (1989) Rate of longitudinal flow of cochlear endolymph. In: Nadol JB (ed) Meniere’s Disease. Kugler, Amsterdam, p 69–73
Salt AN, Vora A (1991) Calibration of ion-selective microelectrodes for use with high levels of interfering ions. JNeurosci Meth 38:233–237
Salt AN, Ohyama K, Thalmann R (1991) Radial communication between the perilymphatic scalae of the cochlea. II: Estimation by bolus injection of tracer into the sealed cochlea. Hear Res 56:37–43
Salt AN, DeMott J (1992) Tetramethylammonium for in vivo marking of the cross-sectional area of scala media in the guinea pig cochlea. Eur Arch Otorhinolaryngol 249:157–163
Salt AN, DeMott J (1995) Endolymph volume changes during osmotic dehydration measured by two marker techniques. Hear Res (in press)
Sterkers O, Saumon G, Tran Ba Huy P et al (1982) K, CI and H2O entry into endolymph, perilymph and cerebrospinal fluid of the rat. Am J Physiol 247:F173-F180
Sziklai I, Ferrary E, Homer KC et al (1992) Time-related alteration of endolymph composition in an experimental model of endolymphatic hydrops. Laryngoscope 102:431–438
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© 1996 Springer-Verlag Berlin Heidelberg
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Salt, A.N. (1996). Longitudinal fluid movements in the cochlea under normal and abnormal conditions. In: Ernst, A., Marchbanks, R., Samii, M. (eds) Intracranial and Intralabyrinthine Fluids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80163-1_3
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DOI: https://doi.org/10.1007/978-3-642-80163-1_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80165-5
Online ISBN: 978-3-642-80163-1
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