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Neurogenesis in the Adult Brain: Lessons Learned from the Studies of Progenitor Cells from the Embryonic and Adult Central Nervous Systems

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Isolation, Characterization and Utilization of CNS Stem Cells

Part of the book series: Research and Perspectives in Neurosciences ((NEUROSCIENCE))

Abstract

The developing brain represents a spectrum of differentiation, encompassing at one end mature differentiated cells with no ability to divide and at the other end a rare, self-sustaining population of stem cells that have the ability to give rise to all the cells of the central nervous system (CNS). In between these two extremes are cells termed progenitor cells, which are functionally immature and retain a limited proliferative capacity (Fig. 1). Although the presence of stem and progenitor cells within the CNS is a subject of great interest and debate, they are elusive cells and have not been definitely identified by the expression of a set of pheno-typic markers, like the stem cells in the hemopoeitic system.

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Authors
  1. J. Ray
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  2. T. D. Palmer
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  3. J. Suhonen
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  4. J. Takahashi
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  5. F. H. Gage
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, The Salk Institute for Biological Studies, P. O. Box 85800, 92186-5800, San Diego, CA, USA

    F. H. Gage Ph. D.

  2. Fondation IPSEN, 24, rue Erlanger, 75781, Paris, Cedex 16, France

    Y. Christen Ph. D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Ray, J., Palmer, T.D., Suhonen, J., Takahashi, J., Gage, F.H. (1997). Neurogenesis in the Adult Brain: Lessons Learned from the Studies of Progenitor Cells from the Embryonic and Adult Central Nervous Systems. In: Gage, F.H., Christen, Y. (eds) Isolation, Characterization and Utilization of CNS Stem Cells. Research and Perspectives in Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80308-6_8

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  • DOI: https://doi.org/10.1007/978-3-642-80308-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80310-9

  • Online ISBN: 978-3-642-80308-6

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