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The Practical Approach

  • Chapter
Allergic Contact Dermatitis

Abstract

In this chapter, we illustrate how an understanding of chemistry can help solve practical allergy problems:

  • Chemical analysis can identify the actual allergen, which need not be the primary chemical constituent of a product, but may be a contaminant arising in the synthesis or production of the product or one formed during its storage and handling.

  • The physicochemical parameters affect the bioavailability and hence the allergenic properties of a given molecule.

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References

  1. Ducombs G, Benezra C, Talaga P et al (1990) Patch testing with the “sesquiterpene lactone mix”: a marker for contact allergy to Compositae and other sesquiterpene lactone containing plants. Contact Dermatitis 22:249 – 252

    Google Scholar 

  2. Dooms-Goossens A, Morren M (1992) Results of routine patch testing with a corticosteroid series in 2073 patients. Contact Dermatitis 26:189–191

    Article  Google Scholar 

  3. Dooms-Goossens A, Bruze M, Buysse L, Fregert S, Gruvberger B, Stals H (1995) Contact allergy to allylglycidylether present as an impurity in 3-glycidyloxypropyltrimethoxy- silane, a fixing additive in silicone and polyurethane resins. Contact Dermatitis 33:17–19

    Article  PubMed  CAS  Google Scholar 

  4. Smook GA (1992) Handbook for pulp and paper technologists, 2nd edn. Wilde, Vancouver, pp 36–44

    Google Scholar 

  5. Ekman R, Holmbom B (1989) Analysis by gas chromatography of the wood extractives in pulp and water samples from mechanical pulping of spruce. Nord Pulp Pap Res J 4:16–24

    Article  CAS  Google Scholar 

  6. Karlberg A-T, Bohlinder K, Boman A, Hacksell U, Hermansson J, Jacobsson S, Nilsson JLG (1988) Identification of 15-hydroperoxyabietic acid as a contact allergen in Portuguese colophony. J Pharm Pharmacol 40:42–47

    Article  PubMed  CAS  Google Scholar 

  7. Karlberg A-T, Boman A, Hacksell U, Jacobsson S, Nilsson, JLG (1988) Contact allergy to dehydroabietic acid derivatives isolated from Portuguese colophony. Contact Dermatitis 19:166–174

    Article  PubMed  CAS  Google Scholar 

  8. Hausen BM, Krohn K, Budianto E (1990) Contact allergy to colophony. VII. Sensitization studies with oxidation products of abietic and related acids. Contact Dermatitis 23: 352–358.

    Article  PubMed  CAS  Google Scholar 

  9. Gäfvert E, Nilsson U, Karlberg A-T, Magnusson K, Nilsson ILG (1992) Rosin allergy: identification of a dehydroabietic acid peroxide with allergenic properties. Arch Dermatol Res 284:409–413

    Article  PubMed  Google Scholar 

  10. Krohn K, Budantio E, Flörke U, Hausen BM (1992) Untersuchung der allergenen Prinzipen aus Kolophonium: Autoxidation, Synthese und Sensibilisierung. Liebigs Ann Chem 911–919

    Google Scholar 

  11. Hausen BM, Börries M, Budianto E, Krohn K (1993) Contact allergy to colophony. IX. Sensitization studies with further products isolated after oxidative degradation of resin acids and colophony. Contact Dermatitis 29:234–240

    Article  PubMed  CAS  Google Scholar 

  12. Gäfvert E, Shao LP, Karlberg A-T, Nilsson U, Nilsson JLG. (1994) Contact allergy to resin acid hydroperoxides. Hapten binding via free radicals and epoxides. Chem Res Toxicol 7:260–266

    Article  PubMed  Google Scholar 

  13. Khan L, Saeed MA (1994) 13/?, 14/?-dihydroxy-13a-isopropylabietic acid, an elicitor of contact allergy. J Pharm Sei 83:909–910

    Article  CAS  Google Scholar 

  14. Shao LP, Gäfvert E, Nilsson U, Karlberg A-T, Nilsson JLG (1995) 15-Hydroperoxy dehydroabietic acid - a contact allergen in colophony from pinus species. Phytochemistry 4:853–857

    Article  Google Scholar 

  15. Karlberg A-T (1991) Air oxidation increases the allergenic potential of tall oil rosin. Gum rosin contact allergens also identified in tall oil rosin. Am J Contact Dermatitis 2:43–49

    Google Scholar 

  16. Ehrin E, Karlberg A-T (1990) Detection of rosin (colophony) components in technical products using an HPLC technique. Contact Dermatitis 23:359–366

    Article  PubMed  CAS  Google Scholar 

  17. Karlberg A-T, Liden C (1992) Colophony (rosin) in newspaper may contribute to hand eczema. Br J Dermatol 126:161–165

    Article  PubMed  CAS  Google Scholar 

  18. Karlberg A-T, Gâfvert E, Lidén C (1995) Environmentally friendly paper may increase risk of hand eczema in rosin-sensitive persons. J Am Acad Dermatol 33:427–432

    Article  PubMed  CAS  Google Scholar 

  19. Klecak G (1985) The Freund’s complete adjuvant test and the open epicutaneous test. Curr Probl Dermatol 185:152–157

    Google Scholar 

  20. Boman A, Karlberg A-T, Wahlberg JE (1988) Experiences with Freund’s complete adjuvant test (FCAT) when screening for contact allergens in colophony. Contact Dermatitis 18:25–29

    Article  PubMed  CAS  Google Scholar 

  21. Lidén C, Karlberg A-T (1992) Colophony in paper as a cause of hand eczema. Contact Dermatitis 26:272–273

    Article  PubMed  Google Scholar 

  22. Karlberg A-T, Gâfvert E, Meding B, Stenberg B (1996) Airborne contact dermatitis from unexpected exposure to rosin (colophony). Contact Dermatitis 35:272–278

    Article  PubMed  CAS  Google Scholar 

  23. Karlberg A-T, Magnusson K, Nilsson U (1994) Influence of an anti-oxidant on the formation of allergenic compounds during auto-oxidation of d-limonene. Ann Occup Hyg 38:199–207

    Article  PubMed  CAS  Google Scholar 

  24. Karlberg A-T, Magnusson K, Nilsson U (1992) Air oxidation of d-limonene (the citrus solvent) creates potent allergens. Contact Dermatitis 26:332–340

    Article  PubMed  CAS  Google Scholar 

  25. Karlberg A-T, Shao LP, Nilsson U, Gâfvert E, Nilsson JLG (1994) Hydroperoxides in oxidized d-limonene identified as potent contact allergens. Arch Dermatol Res 286:97–103

    Article  PubMed  CAS  Google Scholar 

  26. Karlberg A-T, Dooms-Goossens A (1997) Contact allergy to oxidized d-limonene - the citrus solvent. Contact Dermatitis 36:201–206

    Article  PubMed  CAS  Google Scholar 

  27. Meding B, Barregard L, Marcus K (1994) Hand eczema in car mechanics. Contact Dermatitis 30:129–134

    Article  PubMed  CAS  Google Scholar 

  28. Strazdins E (1989) Paper sizes and sizing. In: Zinkel DF, Russel J (eds) Naval stores. Production - chemistry - utilization. Pulp Chemicals Association, New York, pp 575–624

    Google Scholar 

  29. Burke RE (1989) Rosin-based printing inks. In: Zinkel DF, Russel J (eds) Naval stores. Production - chemistry - utilization. Pulp Chemicals Association, New York, pp 665–700

    Google Scholar 

  30. Wherry RW (1989) Other uses for rosin. In: Zinkel DF, Russel J (eds) Naval stores. Production - chemistry - utilization. Pulp Chemicals Association, New York, pp 701–714

    Google Scholar 

  31. Karlberg A-T, Gâfvert E, Hagelthorn G, Nilsson JLG (1988) Maleopimaric acid - a potent sensitizer in modified rosin. Contact Dermatitis 22:193–201

    Article  Google Scholar 

  32. Gâfvert E, Shao LP, Karlberg A-T, Nilsson JLG (1995) Maleopimaric acid - a contact allergen in fumaric acid-modified rosin used for paper size. Nordic Pulp Paper Res J 10:139–144

    Article  Google Scholar 

  33. Gâfvert E (1994) Allergenic components in modified and unmodified rosin. Chemical characterization and studies of allergenic activity. Acta Dermatol Venereol Suppl (Stockh) 184

    Google Scholar 

  34. Gâfvert E, Bordalo O, Karlberg A-T (1996) Patch testing with allergens from modified rosin (colophony) discloses additional cases of contact allergy. Contact Dermatitis 35:290–298

    Article  PubMed  Google Scholar 

  35. Tsuchiya S, Kondo M, Okamoto K, Takase Y (1985) The cumulative contact enhancement test. Curr Probl Dermatol 14:208–219

    PubMed  CAS  Google Scholar 

  36. Lepoittevin J-P (1995) Les “MIX”: du fondamental à la clinique. Le point de vue du chimiste. In: GERDA (ed) Progrès en dermato-allergologie, vol 1. Médiscript, Viterne, pp 185–192

    Google Scholar 

  37. Andersen KE, Burrows D, White IR (1995) Allergens from the standard series. In: Rycroft RJG, Menné T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin Heidelberg New York, pp 416–458

    Google Scholar 

  38. Paulsen E (1992) Compositae dermatitis: a survey. Contact Dermatitis 26:76–86

    Article  PubMed  CAS  Google Scholar 

  39. English JSC, Norris P, White IR, Cronin E (1989) Variability in the clinical patterns of compositae dermatitis. Br J Dermatol 121 [Suppl 34]:27

    Article  Google Scholar 

  40. Benezra C, Ducombs G, Sell Y, Foussereau J (1985) Plant contact dermatitis. Decker, Toronto

    Google Scholar 

  41. Franot C, Benezra C, Lepoittevin JP (1993) Synthesis and interaction studies of 13C labeled lactone derivatives with a model protein using 13C NMR. Biorg Med Chem 1:389–397

    Article  CAS  Google Scholar 

  42. Stampf JL, Schlewer G, Ducombs G, Foussereau J, Benezra C (1978) ACD due to sesquiterpene lactones. A comparative study of human and animal sensitivity to a-methylene- y-butyrolactones and derivatives. Br J Dermatol 99:163–169

    Article  PubMed  CAS  Google Scholar 

  43. Paulsen E, Andersen KE, Hausen BM (1993) Results of routine testing with the sesquiterpene lactone mix supplemented with aimed patch testing with extracts ans sesquiterpene lactones of compositae plants. Contact Dermatitis 29:6–10

    Article  PubMed  CAS  Google Scholar 

  44. Lepoittevin J-P, Drieghe J, Dooms-Goossens A (1995) Studies in patients with corticosteroid contact allergy: Understanding cross-reactivity among different steroids. Arch Dermatol 131:31–37

    Article  PubMed  CAS  Google Scholar 

  45. Lauerma AI, Reitamo S (1994) Allergic reactions to topical and systemic corticosteroids. Eur J Dermatol 5:354–358

    Google Scholar 

  46. Coopman S, Degreef H, Dooms-Goossens A (1989) Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids. Br J Dermatol 121:27 - 34

    Google Scholar 

  47. European Communities (1993) Annex IV to Commission Directive 93/21/EEC of 27 April 1993 adapting to technical progress for the 18th time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Official J Eur Communities 36:59

    Google Scholar 

  48. Barratt MD, Basketter DA, Chamberlain M, Admans GD, Langowski JJ (1994) An expert system rulebase for identifying contact allergens. Toxicol In Vitro 8:1053–1060

    Article  PubMed  CAS  Google Scholar 

  49. Basketter DA, Scholes EW, Chamnerlain M, Barratt MD (1995) An alternative strategy to the use of guinea pigs for the identification of skin sensitization hazard. Food Chem Toxicol 33:1051–1056

    Article  PubMed  CAS  Google Scholar 

  50. Riding JE, Barratt MD, Cary R, Earnshaw CG, Eggington CE, Ellis MK, Judson PN, Langowski JJ, Marchant CA, Payne MP, Watson WP, Yih TD (1996) Computer prediction of possible toxic from chemical structure: an update on the DEREK system. Toxicology 106:267–269

    Article  Google Scholar 

  51. Basketter DA, Cookman G, Gerberick GF, Mamaide H, Potokar M (1997) Skin sensitiation thresholds: determination in predictive models. Food Chem Toxicol 35 (in press)

    Google Scholar 

  52. Basketter DA, Roberts DW, Cronin M, Scholes EW (1992) The value of the local lymph node assay in quantitative structure activity investigations. Contact Dermatitis 27:137–142

    Article  PubMed  CAS  Google Scholar 

  53. Roberts DW, Basketter DA (1990) A quantitative structure activity/dose response relationship for contact allergic potential of alkyl group transfer agents. Contact Dermatitis 23:331–335

    Article  PubMed  CAS  Google Scholar 

  54. Magee PS, Hostynek J J, Maibach HI (1994) A classification model of allergenic contact dermatitis. Quantitative structure activity relationships 13:22–33

    CAS  Google Scholar 

  55. Cronin MTD, Basketter DA (1994) Multivariate QSAR analysis of a skin sensitization database. SAR QSAR Environ Res 2:159–179

    Article  PubMed  CAS  Google Scholar 

  56. Gealy R, Graham C, Sussman NB, Macina OT, Rosenkranz HS, Karol MH (1996) Evaluating clinical case report data for SAR modeling of allergic contact dermatitis. Hum Exp Toxicol 15:489–493

    Article  PubMed  CAS  Google Scholar 

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© 1998 Springer-Verlag Berlin Heidelberg

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Goossens, A., Karlberg, AT., Basketter, D., Lepoittevin, JP. (1998). The Practical Approach. In: Lepoittevin, JP., Basketter, D.A., Goossens, A., Karlberg, AT. (eds) Allergic Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80331-4_9

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  • DOI: https://doi.org/10.1007/978-3-642-80331-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80333-8

  • Online ISBN: 978-3-642-80331-4

  • eBook Packages: Springer Book Archive

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