Abstract
Bladder cancer in rats is a widely used and valuable model in carcinogenesis research. Considerable interest has been centered on this tumor as an end point in carcinogenesis testing and the resulting impact upon regulation of chemicals, such as cyclamate, saccharin, and melamine.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Arai M, Kani T, Sugihara S, Matasumura K, Miyata Y, Shinohara Y, Ito N (1974) Scanning and transmission electron microscopy of changes in the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl) nitrosamine. Gann 65:529–540
Arnold DL, Moodie CA, Grice H, Charbonneau SM, Stavic B, Collins BT, Mcguire PF, Zawidzka ZZ, Munro IC (1980) Long term toxicity of orthotoluenesulfonamide and sodium saccharin in the rat. Toxicol Appl Pharmacol 52:113–152
Boorman GA, Hollander CF (1974) High incidence of spontaneous urinary bladder and ureter tumors in Brown Norway rats. J Natl Cancer Inst 52:1005–1008
Clayson DB (1974) Bladder carcinogenesis in rats and mice: possibility of artifacts. J Natl Cancer Inst 52:1685–1689
Cohen SM (1983) Pathology of experimental bladder cancer in rodents. In: Bryan GT, Cohen SM (eds) The pathology of bladder cancer. CRC Press, Boca Raton, pp1–40
Cohen SM, Ellwein LB (1990) Cell proliferation in carcinogenesis. Science 249:1007–1011
Cohen SM, Friedell GH (1979) Carcinoma of the urinary bladder. Am J Pathol 95:849–852
Durand-Cavagna G, Owen RA, Gordon LR, Peter CP, Boussiquet-Leroux C (1992) Urothelial hyperplasia induced by carbonic anhydrase inhibitors (CAIs) in animals and its relationship to urinary Na and pH. Fundam Appl Toxicol 18:137–143
Friedell GH, Nagy GK, Cohen SM (1983) Pathology of human bladder cancer and related lesions. In: Bryan GT, Cohen SM (eds) The pathology of bladder cancer, voll. CRC Press, Boca Raton
Frith CH, Eighmy JJ, Fukushima S, Cohen SM, Squire RA, Chandra M (1995) Proliferative lesions of the urinary tract in rats. In: Guides for toxicologic pathology. STP/ARP/AFIP, Washington DC
Fukushima S, Hirose M, Tsuda H, Shirai T, Hirao K (1976) Histological classification of urinary bladder cancers in rats induced by N-butyl-n-(4-hydroxybutyl)nitrosamine. Gann 67:81–90
Fukushima C, Cohen SM, Arai M, Jacobs JB, Friedell GH (1981) Scanning electron microscopic examination of reversible hyperplasia of the rat urinary bladder. Am J Pathol 102:373–380
Goodman DG. Ward JM. Squire RA, Chu KC, Linhart MS (1979) Neoplastic and non-neoplastic esions in aging F344 rats. Toxicol Appl Pharmacol 48:237–248
Goodman DG. Ward JM. Squire RA. Paxton MB, Reichardt WD. Chu KC Linhart MS (1980) Neoplasticand non-neoplastic lesions in aging Osborne-Mendel rats. Toxicol Appl Pharmacol 55:433–447
Hicks RM. Chowaniec J (1978) Experimental induction. histology, and ultrastructure of hyperplasia and neoplasia of the urinary bladder epithelium. In: Richter GW, Epstein MA (eds) International review of experimental pathology. Academic, New York, pp 199–280
Hicks RM, Wakefield JJ (1976) Membrane changes during urothelial hyperplasia and neoplasia. Cancer Res 36:2502–2507 Jacobs JB, Arai M, Cohen SM, Friedell GH (1976) Early lesions in experimental bladder cancer: scanning eJectron microscopy of cell surface markers. Cancer Res 36:2512–2517
Koss LG (1984) Atlas of tumor pathology. Fascicle 1l. Tumors of the urinary bladder. Armed Forces Insitute ofPathology. Washington DC (abstr) Lina BA, Hollanders VM, Kuijpers MH (1994) The role of alkalizing and neutral potassium salts in urinary bladder carcinogenesis in rats. Carcinogenesis 15:523–527
Melnick RL, Boorman GA, Haseman JK, Montali RJ, Huff J (1984) Urolithiasis and bladder carcinogenicity of melamine in rodents. Toxicol Appl Pharmacol 72:292–303
Mostofi FK (1973) Histological typing of urinary bladder tumours. World Health Organization. Geneva (abstr)Ozono S, Numata I, Oyasu R (1973) Irreversibility of lowgrade superficial rat bladder carcinomas. Cancer Res 44:4260–4262
Pauli BU, Alroy J, Weinstein RS (1983) The ultrastructure and pathobiology of urinary bladder cancer. In: Bryan GT. Cohen SM (eds) The pathology of bladder cancer. CRC Press, Boca Raton, pp 41–140
Squire RA (1985) Histopathological evaluation of rat urinary bladders from the IRDC two-generation bioassay of sodium saccharin. Food Chern Toxicol 23:491–497
Squire RA, Sporn MB, Brown CC, Smith JM, Went ML, Springer S (1977) Histopathological evaluation of the inhibition of rat bladder carcinogenesis by 13-cis-retinoic acid. Cancer Res 37:2930–2936
Squire RA, Brinkhaus KM. Peiper SC, Firminger HI, Mann RB, Strandberg JD (1981) Histiocytic sarcoma with a granuloma-like component occurring in a large colony of Sprague-Dawley rats. Am J Pathol 105: 21–30
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Squire, R.A. (1998). Classification and Differential Diagnosis of Neoplasms, Urinary Bladder, Rat. In: Jones, T.C., Hard, G.C., Mohr, U. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80335-2_35
Download citation
DOI: https://doi.org/10.1007/978-3-642-80335-2_35
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80337-6
Online ISBN: 978-3-642-80335-2
eBook Packages: Springer Book Archive