Skip to main content
SpringerLink
Log in

Estrogen Receptors and Hormone Dependency in Human Breast Cancer

  • Chapter
Breast Cancer

Abstract

Endocrine ablative and additive hormone therapies have been used widely in the treatment of advanced breast cancer since Sir George Beatson’s report in 1896 describing remissions in response to bilateral oophorectomy (BEATSON, 1896). Either removal of endocrine producing organs or administration of pharmacologic quantities of hormones results in objective remissions in 25–40% of patients with advanced breast disease (KENNEDY, 1974). Recently, the ability to predict with confidence the breast cancer patient most likely to respond to endocrine manipulation was demonstrated using estrogen receptor analyses (e.g., JENSEN et al., 1971; WITTLIFF, 1974; McGUIRE et al., 1975).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. BEATSON, G.T.: On the treatment of inoperable cases of carcinoma of the mamma; suggestions for a new method of treatment with illustrative cases. Lancet II, 104–107 (1896).

    Article  Google Scholar 

  2. BRESCIANI, F., PUCA, G.A., NOLA, E., SICA, V.: Early stages in estrogen control of cell proliferation, p. 67. In: Control of proliferation in animal cells. Clarkson, B. und Baserga, R. (eds.) Cold Spring Harbor Conferences on Cell Proliferation, 1974.

    Google Scholar 

  3. BULLER, R.E., O’MALLEY, B.W.: The biology and mechanism of steroid hormone receptor interaction with the eukaryotic nucleus. Biochem. Pharm. 25, 1–12 (1976).

    Article  PubMed  CAS  Google Scholar 

  4. FISHER, E.R., GREGORIO, R.M., FISHER, B.: The pathology of invasive breast cancer — A syllabus derived from findings of the national surgical adjuvant breast project. Cancer (Philad.) 36, 1–85 (1975).

    Article  CAS  Google Scholar 

  5. FOLCA, P.J., GLASCOCK, R.F., IRVINE, W.T.: Studies with tritium-labeled hexoestrol in advanced breast cancer. Lancet II, 796–7 98 (1961).

    Google Scholar 

  6. GARDNER, D.G., WITTLIFF, J.L.: Specific estrogen receptors in the lactating mammary gland of the rat. Biochemistry 12, 3090–3096 (1973).

    Article  PubMed  CAS  Google Scholar 

  7. GORSKI, J., TOFT, D., SHYAMALA, G., SMITH, D., NOTIDES, A.: Hormone receptors: studies on the interaction of estrogen with the uterus. Recent Progr. Hormone Res. 24, 45–80 (1968).

    PubMed  CAS  Google Scholar 

  8. HÄHNEL, R., TWADDLE, E.: Estimation of the association constant of the estrogen-receptor complex in human breast cancer. Cancer Res. 33, 559–566 (1973).

    PubMed  Google Scholar 

  9. HILF, R., WITTLIFF, J.L.: Characterization of human breast cancer by examination of cytoplasmic enzyme activities and estrogen receptors. In: Hormones and Cancer. McKerns K.W. (ed.) New York-London: Academic Press, 1974, p. 103.

    Google Scholar 

  10. HILF, R., WITTLIFF, J.L.: Mechanisms of action of estrogens. In: Handbook of Experimental Pharmacology. Sartorelli, A.C. and Johns D.G. (eds.). Berlin-Heidelberg-New York: Springer, 1975, p. 103.

    Google Scholar 

  11. JENSEN, E.V., BLOCK, G.E., SMITH, S., KYSER, K., DESOMBRE, E.R.: Estrogen receptors and breast cancer response to adrenalectomy. Nat. Cancer Inst. Monogr. 34, 55–79 (1971a).

    PubMed  CAS  Google Scholar 

  12. JENSEN, E.V., DESOMBRE, E.R., JUNGBLUT, P.W.: Estrogen receptors in hormone-responsive tissues and tumors, p. 15. In: Endogeous factors influencing host-tumor balance. Wissler, R.W., Dao, T.L., and Wood, S., Jr. (eds.) Chicago: Univ. Chicago Press 1967.

    Google Scholar 

  13. JENSEN, E.V., JACOBSON, H.I.: Basic guides to the mechanism of estrogen action. Recent Progr. Hormone Res. 18, 387–414 (1962).

    CAS  Google Scholar 

  14. JENSEN, E.V., MOHLA, S., GORELL, T.A., DESOMBRE, E.R.: The role of estrophilin in estrogen action. Vitam. and Horm. 32, 89–127 (1974).

    Article  CAS  Google Scholar 

  15. JENSEN, E.V., NUMATA, M., BRECHER, P.I., DESOMBRE, E.R.: Hormone-receptor interaction as a guide to biochemical mechanism. Biochem. Soc. Symp. 32, 133–159 (1971b).

    PubMed  CAS  Google Scholar 

  16. JENSEN, E.V., SUZUKU, T., KAWASHIMA, T., STUMPF, W.E., JUNGBLUT, P.W., DESOMBRE, E.R.: A two-step mechanism for the interaction of estradiol with rat uterus. Proc. Nat. Acad. Sci. (Wash.) 59, 632–639 (1968).

    Article  CAS  Google Scholar 

  17. KENNEDY, B.J.: Hormonal therapies in breast cancer. Sem. Oncol. 1, 119–130 (1974).

    CAS  Google Scholar 

  18. LITTLE, M., SZENDRO, P.I., JUNGBLUT, B.W.: Hormone-mediated dimerization of microsomal estradiol receptor. Hoppe-Seylers Z. Physiol. Chem. 354, 1599–1610 (1973).

    Article  PubMed  CAS  Google Scholar 

  19. MCGUIRE, W.L., CARBONE, P.O., VOLLMER, E.P.(eds.): Estrogen receptors in human breast cancer. New York: Raven Press, 1975.

    Google Scholar 

  20. NOTIDES, A.C., NIELSEN, S.: The molecular mechanism of the in vitro 4 S to 5 S transformation of the uterine estrogen receptor. J. Biol. Chem. 249, 1866–1873 (1974).

    PubMed  CAS  Google Scholar 

  21. ROSEN, P.P., MENENDEZ-BOTET, NISSELBAUM, J.S., URBAN, J.A., MIKE, V., FRACCHIA, A., SCHWARTZ, M.K.: Pathological review of breast lesions analyzed for estrogen receptor protein. Cancer Res. 35, 3187–3194 (1975).

    PubMed  CAS  Google Scholar 

  22. SAVLOV, E.D., WITTLIFF, J.L., HILF, R., HALL, T.C.: Correlations between certain biochemical properties of breast cancer and response to therapy: a preliminary report. Cancer (Philad.) 33, 303–309 (1974).

    Article  CAS  Google Scholar 

  23. WITTLIFF, J.L.: Specific receptors of the steroid hormones in breast cancer. Sem. Oncol. 1, 109–118 (1974).

    CAS  Google Scholar 

  24. WITTLIFF, J.L.: Steroid-binding proteins in normal and neoplastic mammary cells. In: Methods in Cancer Research. Busch, H. (ed.). Vol. XI, p. 293, New York: Academic Press 1975.

    Google Scholar 

  25. WITTLIFF, J.L., BEATTY, B.W., BAKER, D.T., JR., SAVLOV, E.D., COOPER, R.A., JR.: Clinical significance of molecular forms of estrogen receptors in human breast cancer. Research on Steroids, in press (1976).

    Google Scholar 

  26. WITTLIFF, J.L., GARDNER, D.G., BATTEMA, W.L., GILBERT, P.J.: Specific estrogen receptors in the neoplastic and lactating mammary gland of the rat. Biochem. Biophys. Res. Commun. 48, 119–125 (1972a).

    Article  PubMed  CAS  Google Scholar 

  27. WITTLIFF, J.L., GARDNER, D.G., BATTEMA, W.L., GILBERT, P.J.: Characterization of a specific estrogen-receptor in the lactating mammary gland of the rat. Presented at IVth Internat. Congr. Endocrinol. Abs. (Excerpta Medica, Intern. Congr. Ser. No. 256), p. 252, 1972b.

    Google Scholar 

  28. WITTLIFF, J.L., HILF, R., BROOKS, W.F., JR., SAVLOV, E.D., HALL, T.C., ORLANDO, R.A.: Specific estrogen-binding capacity of the cytoplasmic receptor in normal and neoplastic breast tissue of humans. Cancer Res. 32, 1983–1992 (1972c).

    PubMed  CAS  Google Scholar 

  29. WITTLIFF, J.L., SAVLOV, E.D.: Estrogen-binding capacity of cytoplasmic forms of the estrogen receptor in human breast cancer, p.73. In: Estrogen receptors in human breast cancer. McGuire, W.L., Carbone, P.P. and Vollmer, E.P. (eds.) New York: Raven Press, 1975.

    Google Scholar 

Download references

Authors
  1. J. L. Wittliff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. W. Beatty
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. D. Savlov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. W. B. Patterson
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. A. Cooper Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut d’hématologie-oncologie de Montréal, 5400 ouest, boulevard Gouin, Montréal, Québec, H4J 1C5, Canada

    Guy St-Arneault

  2. The University of Alberta, Clinical Sciences Building, Edmonton, Alberta, T6G 2G3, Canada

    Pierre Band

  3. Centre Hospitalier Universitaire, Lariboisière, Paris, France

    Lucien Israël M. D. (Professor de Médecine) (Professor de Médecine)

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Wittliff, J.L., Beatty, B.W., Savlov, E.D., Patterson, W.B., Cooper, R.A. (1976). Estrogen Receptors and Hormone Dependency in Human Breast Cancer. In: St-Arneault, G., Band, P., Israël, L. (eds) Breast Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81043-5_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-81043-5_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81045-9

  • Online ISBN: 978-3-642-81043-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation