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Von Willebrand’s Syndrome

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Strategies in Clinical Hematology

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Abstract

Von Willebrand’s disease (VWD) is an inherited bleeding disorder, characterized by spontaneous hemorrhage from mucosal membranes and excessive bleeding following trauma and surgery. Since the original description of the disease [51], it has been recognized that the abnormalities of the hemostatic mechanism are complex [2], a defect of blood coagulation (factor VIII deficiency) being associated with an impaired primary hemostasis (expressed by a prolongation of the skin bleeding time). Our knowledge on VWD has considerably increased since the beginning of this decade. Such progress has largely been related to significant advances in the understanding of the structure and functions of factor VIII.

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Authors and Affiliations

  1. Hemophilia and Thrombosis Centre Angelo Bianchi Bonomi, International Training Centre of the World Federation of Hemophilia, 3rd Institute of Clinical Medicine, University of Milan, Via Pace 15, I-20122, Milan, Italy

    P. M. Mannucci

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  1. P. M. Mannucci
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  1. Medizinische Universitätsklinik, Joseph-Stelzmann-Straße 9, D-5000, Köln 41, Germany

    Rudolf Gross  & Klaus-Peter Hellriegel  & 

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Mannucci, P.M. (1979). Von Willebrand’s Syndrome. In: Gross, R., Hellriegel, KP. (eds) Strategies in Clinical Hematology. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 69. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81371-9_14

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  • DOI: https://doi.org/10.1007/978-3-642-81371-9_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81373-3

  • Online ISBN: 978-3-642-81371-9

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