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Optimizing Combinations of Drugs and Radiation. The Interdigitated Alternating Regimen

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Innovations in Radiation Oncology

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Numerous reviews have been devoted to considering the combination of radiotherapy (RT) and chemotherapy (CT) (Bleehen 1981; Vaeth 1979; Peckham and Collis 1981; Tubiana 1981; Rubin 1984) and they have underlined the importance of the relative timing of the administration of the drugs and the radiation. The time interval and sequence between the delivery of CT and RT exerts an influence on both the tolerance of normal tissues and the probability of local control of the tumor.

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Authors and Affiliations

  1. Institute Gustave-Roussy, F-94800, Villejuif, France

    Maurice Tubiana M.D., Rodrigo Arriagada M.D. & Jean-Marc Cosset M.D.

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  1. Maurice Tubiana M.D.
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  2. Rodrigo Arriagada M.D.
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  3. Jean-Marc Cosset M.D.
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Editors and Affiliations

  1. Division of Experimental Radiation Oncology, Department of Radiation Oncology, University of California, 90024, Los Angeles, CA, USA

    H. Rodney Withers M.D., D.Sc. (Director, Professor) (Director, Professor)

  2. Division of Radiotherapy, The University of Texas M.D. Anderson Hospital and Tumor Institute, 77030, Houston, TX, USA

    Lester J. Peters M.D. (Professor and Head) (Professor and Head)

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Tubiana, M., Arriagada, R., Cosset, JM. (1988). Optimizing Combinations of Drugs and Radiation. The Interdigitated Alternating Regimen. In: Withers, H.R., Peters, L.J. (eds) Innovations in Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83101-0_24

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