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Hyperthermia-Induced Changes in Tumor Microcirculation

  • Conference paper
Application of Hyperthermia in the Treatment of Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 107))

Abstract

A biological rationale for treating malignant tumors with hyperthermia has been provided by a great number of studies in recent years. It became obvious that particularly nutritionally deprived, hypoxic and acidic tumor cells were very sensitive to heat (for a review see Dickson and Calderwood 1980; Overgaard and Bichel 1977; Overgaard 1981; Rhee et al. 1984; Song et al. 1980 a; Streffer 1985; Vaupel et al. 1983). This effect was not limited to tumor cells alone, but the deleterious effect of hyperthermia on microscopic blood channels suggested an inverse relationship between blood flow and thermal sensitivity (Dewhirst et al. 1984; Emami and Song 1984; Gullino et al. 1982; Pence and Song 1986; Reinhold and Endrich 1986; Song 1980b). Up to the present, however, only a few studies have evaluated directly the influence of heat on tumor capillaries.

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Author information

Authors and Affiliations

  1. Abteilung für Chirurgie, Kreiskrankenhaus, Alte Waibstadter Straße 2, 6920, Sinsheim, Germany

    B. Endrich

  2. Institut für Anatomie, Technische Universität, 8000, München, Germany

    F. Hammersen

  3. Abteilung für Experimentelle Chirurgie, Universität Heidelberg, 6900, Heidelberg, Germany

    B. Endrich & K. Messmer

Authors
  1. B. Endrich
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  2. F. Hammersen
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  3. K. Messmer
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Editor information

Editors and Affiliations

  1. Medizinische Klinik III, Klinikum Großhadern, Ludwig-Maximilians-Universität, Marchioninistraße 15, 8000, München 70, Germany

    Rolf D. Issels  & Wolfgang Wilmanns  & 

  2. Gesellschaft für Strahlen- und Umweltforschung (GSF), Institut für Hämatologie, Landwehrstraße 61, 8000, München 2, Germany

    Rolf D. Issels  & Wolfgang Wilmanns  & 

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© 1988 Springer-Verlag Berlin · Heidelberg

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Endrich, B., Hammersen, F., Messmer, K. (1988). Hyperthermia-Induced Changes in Tumor Microcirculation. In: Issels, R.D., Wilmanns, W. (eds) Application of Hyperthermia in the Treatment of Cancer. Recent Results in Cancer Research, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83260-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-83260-4_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83262-8

  • Online ISBN: 978-3-642-83260-4

  • eBook Packages: Springer Book Archive

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