Abstract
The rationale for using hyperthermia to treat malignant disease is based on experimental studies which suggest that tumours may be more susceptible to thermal injury than normal tissues (Field and Bleehen 1979). In particular, solid tumours may have an inadequate vascular supply so that many tumour cells may be in an environment (low nutrient and oxygen supply, low pH) which increases thermal sensitivity. Another consequence of a low blood flow is that removal of heat from a locally heated tumour may be poor so that it reaches higher temperatures than adjacent normal tissues.
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© 1988 Springer-Verlag Berlin Heidelberg
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Law, M.P., Field, S.B. (1988). The Problem of Defining Thermal Dose. In: Hinkelbein, W., Bruggmoser, G., Engelhardt, R., Wannenmacher, M. (eds) Preclinical Hyperthermia. Recent Results in Cancer Research, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83263-5_6
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DOI: https://doi.org/10.1007/978-3-642-83263-5_6
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