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Neurotoxic Effects of Hexacarbons (n-Hexane, Methyl-n-Butylketones; 2,5-Hexane-Dione; 1,4-Diketones)

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Nervous System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

Lesions in the peripheral and central nervous system are not seen grossly.

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References

  • Allen N, Mendell JR, Billmaier DJ, Fontaine RE, O’Neill J (1975) Toxic polyneuropathy due to methyl-H-butylketone. Arch Neurol 32: 209–218

    Article  CAS  PubMed  Google Scholar 

  • Altenkirch H, Wagner HM, Stoltenburg-Didinger G, Steppat R (1982 a) Potentiation of hexacarbon-neurotoxicity by methyl-ethyl-ketone (MEK) and other substances: clinical and experimental aspects. Neurobehav Toxicol Teratol 4: 623–627

    CAS  PubMed  Google Scholar 

  • Altenkirch H, Wagner HM, Stoltenburg-Didinger G, Spencer PS (1982 b) Nervous system responses of rats to subchronic inhalation of H-hexane and w-hexane + methyl-ethyl-ketone mixtures. J Neurol Sci 57: 209–219

    Article  CAS  PubMed  Google Scholar 

  • DeCaprio AP, Olavos EJ, Weber P (1982) Covalent binding of a neurotoxic w-hexane metabolite. Conversion of primary amines to substituted pyrrole adducts by 2,5-hexanedione. Toxicol Appl Pharmacol 65: 440–450

    Article  CAS  PubMed  Google Scholar 

  • Goldman JE, Yen SH (1986) Cytoskeletal protein abnormalities in neurodegenerative diseases. Ann Neurol 19: 209–223

    Article  CAS  PubMed  Google Scholar 

  • Graham DG (1980) Hexane neuropathy: a proposal for pathogenesis of a hazard of occupational exposure and inhalant abuse. Chem Biol Interact 32: 339–345

    Article  CAS  PubMed  Google Scholar 

  • Krasavage WJ, O’Donoghue JL, DiVincenco GD, Terhaar CJ (1980) The relative neurotoxicity of methyl-nbutyl-ketone, n-hexane and their metabolites. Toxicol Appl Pharmacol 52: 433–441

    Article  CAS  PubMed  Google Scholar 

  • Spencer PS, Sabri MI, Schaumburg HH, Moore CL (1979) Does a defect of energy metabolism in the nerve fiber underlie axonal degeneration in polyneuropathies? Ann Neurol 5: 501–507

    Article  CAS  PubMed  Google Scholar 

  • Spencer PS, Couri D, Schaumburg HH (1980 a) n-Hexane and methyl-H-butylketone. In: Spencer PS, Schaumburg HH (eds) Experimental and clinical neurotoxicology. Williams and Wilkins, Baltimore, pp 456–475

    Google Scholar 

  • Spencer PS, Schaumburg HH, Sabri MI, Veronesi B (1980 b) The enlarging view of hexacarbon neurotoxicity. CRC Crit Rev Toxicol 7: 279–356

    Article  CAS  Google Scholar 

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© 1988 Springer-Verlag Berlin Heidelberg

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Stoltenburg-Didinger, G., Altenkirch, H. (1988). Neurotoxic Effects of Hexacarbons (n-Hexane, Methyl-n-Butylketones; 2,5-Hexane-Dione; 1,4-Diketones). In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Nervous System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83516-2_6

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  • DOI: https://doi.org/10.1007/978-3-642-83516-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83518-6

  • Online ISBN: 978-3-642-83516-2

  • eBook Packages: Springer Book Archive

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