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Modulation by Estrogen and Growth Factors of Transforming Growth Factor-Alpha and Epidermal Growth Factor Receptor Expression in Normal and Malignant Human Mammary Epithelial Cells

  • Conference paper
Endocrine Therapy and Growth Regulation of Breast Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 113))

Abstract

A number of well-characterized growth factors, such as epidermal growth factor (EGF) and the insulin-like growth factors (IGFs), can stimulate the proliferation and modify the differentiation of normal and malignant rodent and human mammary epithelial cells (Salomon et al. 1986 a, c). For example, EGF or transforming growth factor-alpha (TGFa) can stimulate the lobulo-alveolar development of mouse mammary glands in organ culture or in vivo (Tonelli and Soroff 1980; Okamoto and Oka 1984; Vonderhaar 1987). In addition, EGF may perform a physiological role in the development of the mouse mammary gland during pregnancy and lactation and in the spontaneous formation of mammary tumors in mice (Okamoto and Oka 1984; Oka et al. 1987; Tsutsumi et al. 1987). Several of these growth factors, such as IGF-I, platelet-derived growth factor (PDGF), TGFa, and TGFß, have been found in the conditioned medium (CM) from several human breast cancer cell lines (Salomon et al. 1984; Dickson et al. 1986; Huff et al. 1986; Bronzert et al. 1987; Knabbe et al. 1987; Peres et al. 1987). The production of TGFa, IGF-I, and TGF/3 can be modulated by estrogens or anti-estrogens, suggesting that the growth-promoting effects of estrogen may be mediated in part by TGFa and/or IGF-I and that the growth-inhibitory effects of anti-estrogen may be mediated by TGF/3 (Dickson et al. 1985; Perroteau et al. 1986; Knabbe et al. 1987; Liu et al. 1987; Peres et al. 1987; Huff et al. 1988). However, it is still unclear whether these or other growth factors are present in mammary tumor cells in vivo and, if so, whether they are involved in the etiology of tumor development and progression. Likewise, there is little information on the distribution and level of expression of similar growth factors in normal mammary epithelial cells at specific times during the development of the mammary gland.

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Author information

Authors and Affiliations

  1. Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

    D. S. Salomon, W. R. Kidwell, N. Kim, F. Ciardiello & S. E. Bates

  2. Medicine Branch, National Cancer Institutes, National Institutes of Health, Bethesda, MD, 20892, USA

    E. Valverius, M. E. Lippman & R. B. Dickson

  3. Lawrence Berkeley Laboratory, University of California, Berkeley, CA, 94720, USA

    M. Stampfer

Authors
  1. D. S. Salomon
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  2. W. R. Kidwell
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  3. N. Kim
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  4. F. Ciardiello
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  5. S. E. Bates
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  6. E. Valverius
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  7. M. E. Lippman
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  8. R. B. Dickson
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  9. M. Stampfer
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Editors and Affiliations

  1. Laboratorien, Kantonsspital Basel, Universitäts-Frauenklinik, Schanzenstraße 46, 4031, Basel, Switzerland

    Urs Eppenberger

  2. Servizio Oncologia Cantonale, Ospedale Civico, 6900, Lugano, Switzerland

    Aron Goldhirsch (Vice-Primario) (Vice-Primario)

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© 1989 Springer-Verlag Berlin Heidelberg

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Salomon, D.S. et al. (1989). Modulation by Estrogen and Growth Factors of Transforming Growth Factor-Alpha and Epidermal Growth Factor Receptor Expression in Normal and Malignant Human Mammary Epithelial Cells. In: Eppenberger, U., Goldhirsch, A. (eds) Endocrine Therapy and Growth Regulation of Breast Cancer. Recent Results in Cancer Research, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83638-1_8

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  • DOI: https://doi.org/10.1007/978-3-642-83638-1_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83640-4

  • Online ISBN: 978-3-642-83638-1

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