Skip to main content

Struktur, Funktion und Pathobiochemie der glomerulären Basalmembran

  • Conference paper
Pathobiochemie und Funktionsdiagnostik der Niere

Part of the book series: Zusammenarbeit von Klinik und Klinischer Chemie ((ZUSAMMENARBEIT))

  • 37 Accesses

Zusammenfassung

Die Nieren bilden den Primärharn durch passive Filtration in den Glomerula. Lange Zeit wurde angenommen, daß ausschließlich die Weite von Poren oder Porenäquivalenten der Glomerulummembran die Molekülgröße der Substanzen bestimmt, die noch filtriert werden können. Diese Annahme der einfachen mechanischen Filterfunktion der Niere führte zu der Vorstellung, daß sie durch Dialysemembranen weitgehend ersetzt werden kann.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Farquhar GM, Courtoy PJ, Lemkin MC, Kanwar YS (1982) Current knowledge of the functional architecture of the glomerular basement membrane in “New Trends in Basement Membrane Research” (Kühn K, Schöne HH, Timpl R eds) Raven Press, New York pp 9–29

    Google Scholar 

  2. Martinez-Hernandez A, Amenta PS (1983) The basement membrane in pathology. Lab Invest 48, 656–677

    PubMed  CAS  Google Scholar 

  3. Timpl R (1989) Structure and biological activity of basement membrane proteins. Eur J Biochem 180, 487–503

    Article  PubMed  CAS  Google Scholar 

  4. Brenner BM, Hostetter TH, Hunes HD (1987) Molecular basis of proteinuria of glomerular origin. N Engl J Med 298, 826–833

    Article  Google Scholar 

  5. Kanwar YS, Farquhar MG (1979) Presence of heparan sulfate in the glomerular basement membrane. Proc Natl Acad Sci USA, 76, 1303–1307

    Article  PubMed  CAS  Google Scholar 

  6. Olgemöller B, Schleicher E, Nerlich A, Wagner EM, Gerbitz KD (1989) Isolation, characterization and immunological determination of basement membrane associated heparan sulfate proteoglycan. Biol Chem Hoppe Seyler 370, 1321–1327

    Article  PubMed  Google Scholar 

  7. Schleicher E, Wagner EM, Olgemöller B, Nerlich A, Gerbitz KD (1989) Characterization and localization of basement membrane associated heparan sulfate proteoglycan in human tissues. Lab Invest 61, 323–332

    PubMed  CAS  Google Scholar 

  8. Mynderse LA, Hassel JR, Kleinman HK, Martin GR, Martinez-Hemandez A (1983) Loss of heparan sulfate proteoglycan from glomerular basement membrane of nephrotic rats. Lab Invest 48, 292–302

    PubMed  CAS  Google Scholar 

  9. Barsky SH, Rao NC, Restrepo C, Liotta LA (1984) Immunocytochemical enhancement of basement membrane antigens by pepsin: application in diagnostic pathology. Am J Clin Path 82, 191–194

    PubMed  CAS  Google Scholar 

  10. Scheinman JI, Foidart J, Michael AF (1980) The immunohistology of glomerular antigens. V. The collagenous antigens of the glomerulus. Lab Invest 43, 373–381

    PubMed  CAS  Google Scholar 

  11. Timpl R, Wick G, Gay S (1977) Antibodies to distinct types of collagens and procollagens and their application in immunohistology. J Immunol Meth 18, 165–175

    Article  CAS  Google Scholar 

  12. Remberger K, Gay S, Adelmann BC (1976) Immunhistochemische Charakterisierung and Lokalisation unterschiedlicher Kollagentypen bei chronischen Nierenerkrankungen. Verh Dtsch Ges Path 60, 314–318

    Google Scholar 

  13. Rumpelt HJ, Langer KH, Schorer K, Straub E, Thanes W (1979) Split and extremely thin glomerular basement membranes in hereditary nephropathy (Alport’s syndrome) Virchows Arch (Pathol Anat) 263, 225–233

    Google Scholar 

  14. Kleppel MM, Kashtan CE, Budkowski RJ, Fish AJ, Michael AF (1987) Alport Familial Nephritis. J Clin Invest 80, 263–266

    Article  PubMed  CAS  Google Scholar 

  15. Nerlich A, Schleicher E (unveröffentlicht)

    Google Scholar 

  16. Schleicher E, Nerlich A, Gerbitz KD (1988) Pathobiochemical aspects of diabetic nephropathy. Klin Wschr 66, 873–882

    Article  PubMed  CAS  Google Scholar 

  17. Beisswenger PI, Spiro RG (1970) Human glomerular basement membrane: Chemical alteration in diabetes mellitus Science 168, 596–598

    CAS  Google Scholar 

  18. Mauer SM, Steffes MW, Brown DM (1981) The kidney in diabetes. Am J Med 70, 603–612

    Article  PubMed  CAS  Google Scholar 

  19. Falk RJ, Scheinman JI, Mauer MS, Michael AF (1983) Polyantigenic expansion of basement membrane constituents in diabetic nephropathy. Diabetes 32 (Suppl. 2), 34–39

    PubMed  Google Scholar 

  20. Bendayan M (1985) Alteration in the distribution of type IV collagen in glomerular basal laminae in diabetic rats as revealed by immunocytochemistry and morphometric approach. Diabetologia 28, 373–378

    Article  PubMed  CAS  Google Scholar 

  21. Budkowski RJ, Langeveld JPM, Wieslander J, Hamilton J, Hudson BG (1987) Localization of the Goodpasture Epitope to a Novel Chain of Basement Membrane Collagen. J Biol Chem 262, 7874–7877

    Google Scholar 

  22. Rohrbach DH, Hassell JR, Kleinman HK, Martin GR (1982) Alterations in basement membrane (heparan sulfate) proteoglycan in diabetic mice. Diabetes 31, 185–188

    Article  PubMed  CAS  Google Scholar 

  23. Kanwar YS, Rosenzweig LJ, Linker A, Jakubowski ML (1983) Decreased de novo synthesis of glomerular proteoglycans in diabetes: Biochemical and autoradiographic evidence. Proc Natl Acad Sci USA 80, 2272–2275

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Schleicher, E., Nerlich, A., Gerbitz, KD. (1991). Struktur, Funktion und Pathobiochemie der glomerulären Basalmembran. In: Guder, W.G., Lang, H. (eds) Pathobiochemie und Funktionsdiagnostik der Niere. Zusammenarbeit von Klinik und Klinischer Chemie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84384-6_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84384-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53525-6

  • Online ISBN: 978-3-642-84384-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics