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Determinants of Neutrophil Adhesion Following Ischemia

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1992

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1992))

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Abstract

Inflammation describes a sequence of events that constitute the host response to foreign invasion and the subsequent reactions that are targeted at repair and restoration of normal physiology. While this process was initially thought to be triggered by bacteria, it is now apparent that many stimuli including tissue ischemia will initiate the inflammatory response and possibly lead to untoward results. Acute tissue ischemia in the heart or brain will itself result in significant morbidity and mortality while in other organs its effects may be more subtle. Superimposed upon the direct effects of ischemia are the indirect results of inflammation. This later process may become inappropriately intense or generalized, leading to severe and unanticipated injury. Thus elective surgical procedures may cause transient tissue ischemia that results in minor and unmeasurable tissue injury. Following trauma and in other clinical settings of prolonged low flow, significant tissue ischemia and injury may occur. In addition to this ischemic injury, reperfusion of these ischemic tissues then results in an additional injury which is mediated by inflammatory cells, complement, cytokines, products of neutrophil oxidative metabolism and granule release.

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Authors
  1. T. F. Lindsay
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  2. J. Hill
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  3. H. B. Hechtman
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Editor information

Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1992 Springer-Verlag Berlin Heidelberg

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Lindsay, T.F., Hill, J., Hechtman, H.B. (1992). Determinants of Neutrophil Adhesion Following Ischemia. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1992. Yearbook of Intensive Care and Emergency Medicine, vol 1992. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84734-9_7

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  • DOI: https://doi.org/10.1007/978-3-642-84734-9_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55241-3

  • Online ISBN: 978-3-642-84734-9

  • eBook Packages: Springer Book Archive

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