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Influence of Aging and Malignant Transformation on Keratinocyte Gene Expression

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Skin Carcinogenesis in Man and in Experimental Models

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 128))

Abstract

Skin cancer is the most common malignancy in humans (Yuspa 1987). Most skin cancers are strongly linked to UV exposure (Aubry and MacGibbon 1985; Stoll and Schwartz 1987; Streilein 1991), but other agents such as chemical carcinogens and immunosuppressants (Yuspa et al. 1980) may also contribute. In addition, age-specific skin cancer incidence rises exponentially during adulthood and available data suggest that advanced age itself, independent of exposure history, may be a risk factor (Lin et al. 1989).

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Authors and Affiliations

  1. USDA Human Nutrition Research Center on Aging, Tufts University, Department of Dermatology, Boston University School of Medicine, Boston, MA, USA

    M. Yaar, J. Arora, M. Garmyn, A. Gilani & B. A. Gilchrest

Authors
  1. M. Yaar
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  2. J. Arora
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  3. M. Garmyn
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  4. A. Gilani
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  5. B. A. Gilchrest
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Editor information

Editors and Affiliations

  1. Division: Mechanisms of Tumorigenesis, Research Program 3: Risk Factors of Cancer and Cancer Prevention, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, W-6900, Heidelberg, Germany

    Erich Hecker

  2. Department of Dermatology, Mannheim Medical School, University of Heidelberg, Postfach 10 80 23, Theodor-Kutzer-Ufer, W-6800, Mannheim, Germany

    E. G. Jung (Director) (Director)

  3. Division: Biochemistry of Tissue Specific Regulation, Research Program 2: Tumor Cell Regulation, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, W-6900, Heidelberg, Germany

    F. Marks

  4. Department of Dermatology, University of Heidelberg, Voss-Str. 2, W-6900, Heidelberg, Germany

    W. Tilgen

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© 1993 Springer-Verlag Berlin · Heidelberg

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Yaar, M., Arora, J., Garmyn, M., Gilani, A., Gilchrest, B.A. (1993). Influence of Aging and Malignant Transformation on Keratinocyte Gene Expression. In: Hecker, E., Jung, E.G., Marks, F., Tilgen, W. (eds) Skin Carcinogenesis in Man and in Experimental Models. Recent Results in Cancer Research, vol 128. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84881-0_15

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  • DOI: https://doi.org/10.1007/978-3-642-84881-0_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84883-4

  • Online ISBN: 978-3-642-84881-0

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