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Oncogenes and Tumor Suppressor Genes

  • Chapter
Familial and Hereditary Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 136))

Abstract

During the last 20–30 years, a large body of epidemiologic, cytogenetic, and experimental studies have supported the hypothesis that tumors are caused by genetic damage. The recent advances in molecular biology have definitively proved that this hypothesis was correct, and at present there is no doubt that the basic lesion of the malignant cell is an abnormality in the DNA structure or sequence which results in uncontrolled growth. Two particular classes of genes have been identified — oncogenes and tumor suppressor genes — which are of major importance in the initiation and progression of human malignancies [1].

The striking advances in cancer genetics during the past fifteen years have made it clear that the root causes of this disease are linked to malfunctioning genes. R. A. Weinberg (1992)

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Authors and Affiliations

  1. Istituto di Patologia Medica Policlinico, Università degli Studi di Modena, Via del Pozzo, 71, 41100, Modena, Italy

    Prof. Dr. M. Ponz de Leon

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  1. Prof. Dr. M. Ponz de Leon
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© 1994 Springer-Verlag Berlin Heidelberg

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de Leon, M.P. (1994). Oncogenes and Tumor Suppressor Genes. In: Familial and Hereditary Tumors. Recent Results in Cancer Research, vol 136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85076-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-85076-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85078-3

  • Online ISBN: 978-3-642-85076-9

  • eBook Packages: Springer Book Archive

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