Abstract
Botulism is a very serious foodborne illness, often fatal, and characterized by neuroparalytic signs and symptoms. Early observations found an association with consumption of sausages, and thus the name botulism (derived from botulus, Latin for sausage) was given to the disease (Smith and Sugiyama 1988). Foodborne botulism is the result of ingestion of food containing neurotoxin produced by Clostridium botulinum. The disease may also result from toxin produced in vivo by organisms growing in an infected wound (wound botulism) or colonizing the intestinal tract (infant botulism).
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References
Arnon SS (1992a) Clinical trial of human botulism immune globulin. In: DasGupta BR (ed) Botulinum and tetanus neurotoxins: neurotransmission and biomedical aspects. Plenum, New York
Arnon SS (1992b) Infant botulism. In: Feigen RD, Cherry JD (eds) Textbook of pediatric infectious diseases, 3rd edn. Saunders, Philadelphia
Aureli P, Fenicia L, Pasolini B, Gianfranceschi M, McCroskey LM, Hatheway CL (1986) Two cases of type E infant botulism caused by neurotoxigenic Clostridium butyricum in Italy. J Infect Dis 154: 201–206
Aureli P, Fenicia L, Ferrini AM, Martini M, Beccia G (1992) Wound botulism: clinical and microbiological findings of an Italian case. Eur J Epidemiol 8: 750–752
Barsanti JA, Walser M, Hatheway CL, Bowen JM, Crowell W (1978) Type C botulism in American foxhounds. J Am Vet Med Assoc 172: 809–813
Bengston IA (1924) Studies on organisms concerned as causative factors in botulism. Hyg Lab Bull 136 136:101
Bernard W, Divers TJ, Whitlock RH, Messick J, Tulleners E (1987) Botulism as a sequel to open castration in a horse. J Am Vet Med Assoc 191: 73–74
Bizzini B (1989) Axoplasmic transport and transynaptic movement of tetanus toxin. In: Simpson LL (ed) Botulinum neurotoxin and tetanus toxin. Academic, San Diego
Black RE, Gunn RA (1980) Hypersensitivity reactions associated with botulinal antitoxin. Am J Med 69: 567–570
Cardella MA (1964) Botulinum toxoids. In: Lewis KH, Cassel K jr (eds) Botulism: proceedings of a symposium. US Department of Health, Education, and Welfare, Public Health Service (PHS Publ no 999 FP-1), Cincinnati
Cato EP, George WL, Finegold SM (1986) Genus Clostridium. In: Sneath PHA, Mair NS, Sharpe ME, Holt JG (eds) Bergey’s manual of systematic bacteriology, vol 2. Williams and Wilkins, Baltimore
CDC (1979) Botulism in the United States, 1899–1977. Handbook for epidemiologists, clinicians, and laboratory workers. CDC, Atlanta
CDC (1993) Summary of notifiable diseases, United States 1992. MMWR 41 (55): 1–65
Chia JK, Clark JB, Ryan CA, Pollack M (1986) Botulism in an adult associated with food-borne intestinal infection with Clostridium botulinum. N Engl J Med 315: 239–241
Ciccarelli AS, Giulietti AM, Giménez GF (1976) Segunda cepa de Clostridium botulinum tipo G. Primer Congresso y IV Jomadas Argentinas de Microbiologia 21 (abstract)
Corsi FM, DiBattista G, Galgani S, Piazza G (1979) Su un caso di botulismo da ferita. Riv Neurobiol 25: 200–205
Critchley EMR (1991) A comparison of human and animal botulism: a review. J R Soc Med 84: 295–298
Davis JB, Mattman LH, Wiley M (1951) Clostridium botulinum in a fatal wound infection. JAMA 146: 646–648
Demarchi J, Mourgues C, Oho J, Prevot AR (1958) Existence du-botulisme humain de type D. Bull Acad Natl Med 142: 580–582
DeVeze JL, Jougland J, LaBastie J, Sans P, Arditi J (1979) Botulisme d’inoculation: quand fautil y penser? Nouv Presse Med 8: 2755–2756
Divers TJ, Bartholomew RC, Messick JB, Whitlock RH, Sweeney RW (1986) Clostridium botulinum type B toxicosis in a herd of cattle and a group of mules. J Am Vet Med Assoc 188: 382–386
Dodds KL (1992a) Clostridium botulinum in the environment. In: Hauschild AHW, Dodds KL (eds) Clostridium botulinum: ecology and control in foods. Dekker, New York
Dodds KL (1992b) Worldwide incidence and ecology of infant botulism. In: Hauschild AHW, Dodds KL (eds) Clostridium botulinum: ecology and control in foods. Dekker, New York
Dowell VRJ, McCroskey LM, Hatheway CL, Lombard GL, Hughes JM, Merson MH (1977) Copro-examination for botulinal toxin and Clostridium botulinum. A new procedure for laboratory diagnosis of botulism. JAMA 238: 1829–1832
Eklund MW, Dowell VR Jr (eds) (1987) Avian botulism: an international perspective. Thomas, Springfield
Eklund MW, Poysky F, Oguma K, Iida H, Inoue K (1987) Relationship of bacteriophages to toxin and hemagglutinin production and its significance in avian botulism outbreaks. In: Eklund MW, Dowell VR Jr (eds) Avian botulism: an international perspective. Thomas, Springfield
English WL, Williams LP, Bryant RE, Gillies MD (1981) Case 48–1980: botulism; letter to the editor. N Engl J Med 304: 789–790
Fullerton P, Gogna NK, Stoddart R (1980) Wound botulism. Med J Aust 1: 662–663
Giménez DF (1984) Clostridium botulinum subtype Ba. Zentralbl Bakteriol Hyg [A] 257: 68–72
Giménez DF, Ciccarelli AS (1970) Another type of Clostridium botulinum. Zentralbl Bakteriol I Abt Orig A 215:221–224
Griffin PM, Hatheway CL, Rosenbaum RB, Sokolow R (1994) Type A botulism due to intestinal colonization in an adult with Crohn’s disease associated with an immune response to the toxin. Manuscript in preparation
Hall JD, McCroskey LM, Pincomb BJ, Hatheway CL (1985) Isolation of an organism resembling Clostridium barati which produces type F botulinal toxin from an infant with botulism. J din Microbiol 21:654–655
Hatheway CL (1988) Botulism. In: Balows A, Hausler WH Jr, Ohashi M, Turano A (eds) Laboratory diagnosis of infectious diseases: principles and practice, vol 1. Springer, Berlin Heidelberg, New York
Hatheway CL, McCroskey LM (1987) Examination of feces and serum for diagnosis of infant botulism in 336 patients. J Clin Microbiol 25: 2334–2338
Hatheway CL, McCroskey LM (1989) Unusual neurotoxigenic Clostridia recovered from human fecal specimens in the investigation of botulism. In: Hattori T, Ishida Y, Maruyama Y, Morita RY, Uchida A (eds) Proceedings of the 5th International Symposium on Microbiol Ecology: recent advances in microbiol ecology. Japan Scientific Societies, Tokyo
Hatheway CL, McCroskey LM, Lombard GL, Dowell VRJ (1981) Atypical toxin variant of Clostridium botulinum type B associated with infant botulism. J Clin Microbiol 14: 607–611
Hatheway CL, Snyder JD, Seals JE, Edell TA, Lewis GE Jr (1984) Antitoxin levels in botulism patients treated with trivalent equine botulism antitoxin to toxin types A, B, and E. J Infect Dis 150: 407–412
Hauschild AHW (1992) Epidemiology of human foodbome botulism. In: Hauschild AHW, Dodds KL (eds) Clostridium botulinum: ecology and control in foods. Dekker, New York
Hughes JM, Blumenthal JR, Merson MH, Lombard GL, Dowell VR Jr, Gangarosa EJ (1981) Clinical features of type A and B food-borne botulism. Ann Intern Med 95: 442–445
Jensen WI, Price Jl (1987) The global importance of type C botulism in wild birds. In: Eklund MW, Dowell VR Jr (eds) Avian botulism: an international perspective. Thomas, Springfield
Johnston J, Whitlock RH (1987) botulism. In: Robinson NE (ed) Current theraphy in equine medicine, 2nd edn. Saunders, Philadelphia
Kempner W (1897) Weiterer Beitrag zur Lehre von der Fleischvergiftung. Das Antitoxin des Botulismus. Z Hyg Infektionskh 26: 481–500
Landmann G (1904) Ueber die Ursache der Darmstaedter Bohnenvergiftung. Hyg Rundsch 14:449–452
Lee WH, Riemann H (1970a) Correlation of toxic and nontoxic strains of Clostridium botulinum by DNA composition and homology. J Gen Microbiol 60: 117–123
Lee WH, Riemann H (1970b) The genetic relatedness of proteolytic Clostridium botulinum strains. J Gen Microbiol 64: 85–90
Leuchs J (1910) Beitraege zur Kenntnis des Toxins und Antitoxins des Bacillus botulinus. Z Hyg Infektskh 65: 55–84
MacDonald KL, Spengler RF, Hatheway CL, Hargrett NT, Cohen ML (1985) Type A botulism from sauteed onions. JAMA 253: 1275–1278
Mann JM, Hatheway CL, Gardiner TM (1982) Laboratory diagnosis in a large outbreak of type A botulism. Am J Epidemiol 115: 598–605
McCroskey LM, Hatheway CL (1988) Laboratory findings in four cases of adult botulism suggest colonization of the intestinal tract. J Clin Microbiol 26: 1052–1054
McCroskey LM, Hatheway CL, Fenicia L, Pasolini B, Aureli P (1986) Characterization of an organism that produces type E botulinal toxin but which resembles Clostridium butyricum from the feces of an infant with type E botulism. J Clin Microbiol 23: 201–202
McCroskey LM, Hatheway CL, Woodruff BA, Greenberg JA, Jurgenson P (1991) Type F botulism due to neurotoxigenic Clostridium baratii from an unknown source in an adult. J Clin Microbiol 29: 2618–2620
Merson MH, Dowell VR Jr (1973) Epidemiologic, clinical and laboratory aspects of wound botulism. N Engl J Med 289: 1105–1110
Meyer KF, Dubovsky BJ (1922) The distribution of spores of B. botulinus in the United States. J Infect Dis 31: 559–594
Midura TF, Arnon SS (1976) Infant botulism: identification of Clostridium botulinum and its toxin in faeces. Lancet ii: 934–936
Morris JG (1981) Current trends in theraphy of botulism in the United States. In: Lewis GE jr (ed) Biomedical aspects of botulism. Academic New York
Nakamura S, Okado I, Nakashio S, Nishida S (1977) Clostridium sporogenes isolates and their relationship to C. botulinum based on deoxyribonucleic acid reassociation. J Gen Microbiol 100: 395–401
Nakamura S, Kimura I, Yamakawa K, Nishida S (1983) Taxonomic relationships among Clostridium novyi types A and B, Clostridium haemolyticum and Clostridium botulinum type C. J Gen Microbiol 129: 1473–1479
Notermans S, Nagel J (1989) Assays for botulinum and tetanus toxins. In: Simpson LL (ed) Botulinum neurotoxin and tetanus toxin. Academic San Diego
Pickett J, Berg B, Chaplin E, Brunstetter MA (1976) Syndrome of botulism in infancy: clinical and electrophysiologic study. N Engl J Med 295: 770–772
Prevot AR (1953) Rapport d’’introduction du President du Sous-Comite Clostridium pour l’ unification de la nomenclature des types toxigeniques de C. botulinum. Int Bull Bacteriol Nomenclature 3:120–123
Prevot AR, Terrasse J, Daumail J, Cavaroc M, Riol J, Sillioc R (1955) Existence en France du botulisme humain de type C. Bull Acad Med (Paris) 139: 355–358
Richmond RN, Hatheway CL, Kaufmann AF (1978) Type C botulism in a dog. J Am Vet Med Assoc 173: 202–203
Seals JE, Snyder JD, Edell TA, Hatheway CL, Johnson CJ, Swanson RC, Hughes JM (1981) Restaurant associated type A botulism: transmission by potato salad. Am J Epidemiol 113: 436–444
Sebald M, Jouglard J (1977) Aspects actuels du botulisme. Rev Prat 27: 173–176
Sebald M, Saimot G (1973) Toxémie botulique: intérét de sa mise en évidence dans le diagnostic du botulisme humain de type B. Ann Microbiol (Inst Pasteur) 124A: 61–69
Seddon HR (1922) Bulbar paralysis in cattle due to the action of a toxicogenic bacillus with a discussion of the relationship of the condition to forage poisoning (botulism). J Comp Pathol Ther 35:147–190
Smith LDS (1978) The occurrence of Clostridium botulinum and Clostridium tetani in the soil of the United States. Health Lab Sci 15: 74–80
Smith LDS, Sugiyama H (1988) Botulism: the organism, its toxins, the disease, 2nd edn. Thomas, Springfield
Sonnabend O, Sonnabend W, Heinzle R, Sigrist T, Dimhofer R, Krech U (1981) Isolation of Clostridium botulinum type G and identification of type G botulinal toxin in humans: report of five sudden unexpected deaths. J Infect Dis 143: 22–27
Suen JC, Hatheway CL, Steigerwalt AG, Brenner DJ (1988a) Clostridium argentinense, sp. nov: a genetically homogenous group composed of all strains of Clostridium botulinum toxin type G and some nontoxigenic strains previously identified as Clostridium subterminale or Clostridium hastiforme. Int J Syst Bacteriol 38: 375–381
Suen JC, Hatheway CL, Steigerwalt AG, Brenner DJ (1988b) Genetic confirmation of identities of neurotoxigenic Clostridium baratii and Clostridium butyricum implicated as agents of infant botulism. J Clin Microbiol 26: 2191–2192
Swerczek TW (1980a) Experimentally induced toxicoinfectious botulism in horses and foals. Am J Vet Res 41: 348–350
Swerczek TW (1980b) Toxicoinfectious botulism in foals and adult horses. J Am Vet Med Assoc 176:217
Tacket CO, Shandera WX, Mann JM, Hargrett NT, Blake PA (1984) Equine antitoxin use and other factors that predict outcome in type A foodbome botulism. Am J Med 76: 794–798
Terranova W, Breman JG, Locey RP, Speck S (1978) Botulism type B: epidemiologic aspects of an extensive outbreak. Am J Epidemiol 108: 150–156
Van Ermengem E (1897) Ueber einen neuen anaeroben Bacillus and seine Beziehungen zum Botulismus. Z Hyg Infektionskh 26: 1–56
Wainwright RB, Heyward WL, Middaugh JP, Hatheway CL, Harpster AP, Bender TR (1988) Foodborne botulism in Alaska, 1947–1985: epidemiology and clinical findings. J Infect Dis 157: 1158–1162
Wang WJ, Wang LP (1983) Wound botulism: report of a case complicating a head injury. Chin J Med 96: 315–317
Weber JT, Goodpasture HC, Alexander H, Werner SB, Hatheway CL, Tauxe RV (1993) Wound botulism in a patient with a tooth abcess: case report and review. Clin Infect Dis 16: 635–639
Woodruff BA, Griffin PM, McCroskey LM, Smart JF, Wainwright RB, Bryant RG, Hutwagner LC, Hatheway CL (1992) Clinical and laboratory comparison of botulism from toxin types A, B, and E in the United States, 1975–1988. J Infect Dis 166: 1281–1286
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Hatheway, C.L. (1995). Botulism: The Present Status of the Disease. In: Montecucco, C. (eds) Clostridial Neurotoxins. Current Topics in Microbiology and Immunology, vol 195. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85173-5_3
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DOI: https://doi.org/10.1007/978-3-642-85173-5_3
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