Zusammenfassung
Das Schrifttum der letzten 3 Jahre ergibt für die Therapie der akuten myeloischen Leukämie folgende Ergebnisse:
Komplette Remissionen wurden in 45—63% erzielt (Übersicht [3]). Spitzenwerte über 70% beziehen sich auf insgesamt 16 Patienten unter 60 Jahren [21], im 2. Fall auf 34 Patienten [10].
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Literatur
Bekesi, J. G., Holland, J. F., Fleminger, R., Yates, J., Henderson, E. S.: Immunotherapeutic efficiency of neuraminidase-treated allegeneic myeloblasts in patients with acute myelocytic leukemia. In: Control of neoplasia by modulation of the immune system (ed. M. A. Chirigos). New York: Raven Press 1977.
Bodey, G. P., Coltman, C. A., Hewlett, J. S., Freireich, E. J. (SWOG): Progress in the treatment of adults with acute leukemia. Arch, intern. Med. 136, 1383 (1976).
Büchner, Th., Kamanabroo, D., Urbanitz, D., Hiddemann, W., Van de Loo, J.: Clinical and cell kinetic data on the combination of cytosine arabinosi-de with daunorubicin, ifosfamide, thioguanine, and vincristine for remission induction and maintenance in patients with acute myelocytic leukemia. Blut 1978 (im Druck).
Bull, J., Duttera, M., Stashick, E. et al.: Serial in vitro marrow culture in acute myelocytic leukemia. Blood 42, 679 (1973).
Burge, P. S., Richards, J. D. M., Thrompson, D. S., Prankerd, T. A. J., Sare, M., Wright, P.: Quality and quantity of survival in acute leukemia. Lancet 1975 II, 621.
Carey, R. W., Ribas-Mundo, M., Ellison, R. R., Glidewell, O., Lee, S. T., Cuttner, J., Levy, R. N., Silver, R., Blom, J., Haurani, F., Spurr, C. L., Harley, J. B., Kyle, R., Moon, J. H., Eagan, R. T., Holland, J. H.: Comparative study of cytosine arabinoside therapy alone and combined with thioguanine, mercaptopurine, or daunorubicin in acute myelocytic leukemia. Cancer 36, 1560 (1975).
Clarkson, B. D., Dowling, M. D., Gee, T. S., Cunningham, I. B., Burchenal, J. H.: Treatment of acute leukemia in adults. Cancer 36, 775 (1975).
Freireich, E. J., Bodey, G. P., McCredie, K. B., Hersh, E. M., Gehan, E. A., Hart, J., Gutterman, J. V., Rodriguez, V., Smith, T., Hester, J. P.: Developmental therapy in adult acute leukemia. Arch, intern. Med. 136, 1417 (1976).
Fülle, H. H.: Induktions- und Erhaltungstherapie der akuten myeloischen Leukamie des Erwachsenen durch sequen-tielle Anwendung cytostatischer Chemotherapiekombinationen. Med. Klin. 72,642 (1977).
Gale, R. P., Cline, M. J.: High remission induction rate in acute myeloid leukemia. Lancet 1977 II, 497.
Gerecke, D., Hirschmann, W. D., Voigtmann, R., Hellriegel, K. P., Gross, R.: Remission induction and remission maintenance in adult acute non-lymphocytic leukemia employing a modified COAP regimen. Europ. J. Cancer (in press).
Greenberg, P., Box, L, Mara, B., Schrier, S.: Alterations of granulopoiesis following chemotherapy. Blood 44, 375 (1974).
Guttermann, J. U., Hersh, E. M., Rodriguez, V., McCredie, K. B., Malvligit, G., Reed, R., Burgess, M. A., Smith, T., Gehan, E., Bodey, G. P., Freireich, E. J.: Chemotherapy of adult leukemia. Prolongation of remission in myeloblastic leukemia with BCG. Lancet 1974 II, 1405.
Harriss, E. B., Hoelzer, D.: Proliferative state of normal in vitro colony forming cells during development of the L5222 rat leukemia and their reaction to chemotherapy. Blood (in press).
Manaster, J., Cowan, D. H., Curtis, J. E., Hasselbach, R., Bergsagel, D. E.: Remission maintenance of acute nonlymphoblastic leukemia with BCNU and cyclophosphamide. Cancer Chemother. Rep. 59, 537 (1975).
Powles, R. L., Russel, J., Lister, T. A., Oliver, T., Whitehouse, J. M. A., Malpas, J., Chapuis, B., Crowther, D., Alexander, P.: Immunotherapy for acute myelogenous leukemia: a controlled clinical study 2.5 years after entry of the last patient. Brit. J. Cancer 35, 265 (1977).
Pralle, H., Löffler, H.: Erfahrungen mit der Kombinationschemotherapie (COAP- und TRAP-Schemata) bei unreifzelligen granu- locytaren Leukamien (Peroxydase-Typ) des Erwachsenen. Med. Welt 26, 1783 (1975).
Sotto, J. J., Hollard, D., Schaerer, R., Bensa, J. C, Seigneurin, D.: Androgènes et rémissions prolongées dans les leucemies aigues non lymphoblastiques. Nouv. Rev. franc. Hémat. 15,57 (1975).
Weil, M., Jacquillat, C. I., Gemmon-Auclerc, M. F., Chastang, C. L., Izrael, V., Boiron, M., Bernard, J.: Acute granulocytic leukemia: treatment of the disease. Arch, intern. Med. 136, 1389 (1976).
Wiernick, P. H.: Advances in the management of acute nonlymphocytic leukemia. Arch, intern. Med. 136, 1399 (1976).
Yates, J. W., Wallace, H. R. jr., Ellison, R. R., Holland, J. F.: Cytosine arabinoside and daunorubicin therapy in acute nonlymphocytic leukemia. Cancer Chemother. Rep. 57, 81 (1973).
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Büchner, T., Kamanabroo, D., Hiddemann, W., Urbanitz, D. (1978). Behandlung der akuten myeloischen Leukämie mit Cytosin-arabinosid in Kombination mit Daunorubicin bzw. Ifosfamid bzw. Thioguanin. In: Schlegel, B. (eds) 84. Kongreß. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 84. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-85453-8_25
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