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Ulkuskrankheit

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Medikamentöse Therapie in der Gastroenterologie

Part of the book series: Kliniktaschenbücher ((KTB))

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Zusammenfassung

Ulcus ventriculi und duodeni sind Schleimhautdefekte, die kraterförmig über die Lamina muscularis mucosae hinaus in die Wand von Magen oder Duodenum penetrieren. Prädilektionsort des Ulcus ventriculi ist die kleine Kurvatur des Magens, des Ulcus duodeni der Bulbus duodeni. Die Inzidenz der Ulkuskrankheit ist großen geographischen Schwankungen unterworfen. Epidemiologische Studien in Nordeuropa haben gezeigt, daß pro Jahr 4 von 10000 Personen an einem Ulcus ventriculi und 13 von 10000 an einem Ulcus duodeni erkranken, wobei in den letzten 20 Jahren die Häufigkeit der Ulkuskrankheit eindeutig abnimmt [1]. Männer sind etwa doppelt so häufig betroffen wie Frauen.

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Literatur

  1. Sonnenberg A (1985) Geographic and temporal variations in the occurrence of peptic ulcer disease. Scand J Gastroenterol 20 [Suppl] 110: 11–24

    Article  CAS  Google Scholar 

  2. Johansson C, Kollberg B, Nordemar R, Samuelson K, Bergström S (1980) Protective effect of prostaglandin E2 in the gastrointestinal tract during indomethacin treatment of rheumatic diseases. Gastroenterology 78:479–483

    PubMed  CAS  Google Scholar 

  3. Du Plessis DJ (1965) Pathogenesis of gastric ulceration. Lancet I: 974–978

    Google Scholar 

  4. Dragstedt LL, Woddward ER (1970) Gastric stasis -a cause of gastric ulcers. Scand J Gastroenterol [Suppl.] 6: 243–252

    CAS  Google Scholar 

  5. Price AB, Levi J, Dolby JM, Dunscombe PL, Smith A, Clark J, Stephenson ML (1985) Campylobacter pyloridis in peptic ulcer disease: microbiology, pathology, and scanning electron microscopy. Gut 26: 1183–1188

    Article  PubMed  CAS  Google Scholar 

  6. Bode G, Malfertheiner P, Ditschuneit H (1987) Invasion of Campylobacter -like organisms in the duodenal mucosa in patients with active duodenal ulcer. Klin Wochenschr 65: 144–146

    Article  PubMed  CAS  Google Scholar 

  7. Slomiany BL, Bilski J, Sarosiek J et al. (1987) Campylobacter pyloridis degrades mucin and undermines gastric mucosal integrity. Biochem Biophys Res Commun 144: 307–314

    Article  PubMed  CAS  Google Scholar 

  8. Coghlan JG, Humphries H, Dooley C et al. (1987) Campylobacter pylori and recurrence of duodenal ulcers -a 12 month follow up study. Lancet II:1109–1111

    Google Scholar 

  9. Barakat MH, Menon KN, Badawi AR (1984) Cigarette smoking and duodenal ulcer healing. An endoscopic study of 197 patients. Digestion 29: 85–90

    CAS  Google Scholar 

  10. Blum AL (1985) Stellung der Antacida in der modernen Ulkus-Therapie. Dtsch Med Wochenschr 110: 3–7

    Article  PubMed  CAS  Google Scholar 

  11. Tarnawski A, Hollander D, Cummings D, Krause UJ, Gergely R, Zipser D (1984) Are antacids acid neutralizers only? Histologic, ultrastructural and functional changes in normal gastric mucosa induced by antacids. Gastroenterology 86: 1276 (Abstract)

    Google Scholar 

  12. Becker G, Overhoff H, Forth W (1979) 1st Aluminium ungiftig? Dtsch Ärztebl 24: 1639–1642

    Google Scholar 

  13. Holtermüller KH, Büchler R, Sinterhauf K (1975) Die Wirkung von oralem Calcium und Magnesium auf die Magensäuresekretion und Gastrinfreisetzung bei Patienten mit Ulcus duodeni. Verh Dtsch Ges Inn Med 81: 1237–1238

    PubMed  Google Scholar 

  14. Fordtran JS, Morawsky SG, Richardson CT (1973) In vivo and in vitro evaluation of liquid antacids. N Engl J Med 288: 923–928

    Article  PubMed  CAS  Google Scholar 

  15. Peterson WL, Fordtran JS (1978) Reduction of gastric acidity. In: Sleisenger MH, Fordtran JS (eds) Gastrointestinal disease. Saunders, Philadelphia London Toronto, pp 891–913

    Google Scholar 

  16. Domschke W, Lux G, Domschke S (1980) Furan H2-Antagonist ranitidine inhibits pentagastrin-stimulated gastric secretion stronger than Cimetidine. Gastoenterology 79: 1267–1271

    CAS  Google Scholar 

  17. Sewing KF, Billian A, Malchow H (1980) Comparative study with ranitidine and Cimetidine on gastric secretion in normal volunteers. Gut 21: 750–752

    Article  PubMed  CAS  Google Scholar 

  18. Brater DG, Peters MN, Eskelman FN, Richardson CT (1982) Clinical comparison of Cimetidine and ranitidine. Clin Pharmacol Ther 32: 484–488

    Article  PubMed  CAS  Google Scholar 

  19. Miwa M, Tani N, Miwa T (1984) Inhibiton of gastric secretion by a new H2-antagonist, YM-11170 in healthy subjects. Int J Clin Pharmacol 4: 214–217

    Google Scholar 

  20. Peter P, Kiene K, Gouvers JJ et al. (1978) Cimetidin in der Behandlung des Ulcus duodeni. Dtsch Med Wochenschr 103: 1163–1166

    Article  PubMed  CAS  Google Scholar 

  21. Brogden RN, Carmine AA, Heel RC, Speight TM, Avery GS (1982) Ranitidine, a review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases. Drugs 24: 267–303

    Article  PubMed  CAS  Google Scholar 

  22. Dammann HG, Barbara L, Bianchi-Porro G et al. (1985) Beschleunigte Heilung des Ulcus ventriculi unter einer abendlichen Einzeldosis von Famotidin. Schweiz Med Wochenschr 115: 484–488

    PubMed  CAS  Google Scholar 

  23. Farley AD, Lévesque P, Pare ABR et al. (1985) A comparative trial of ranitidine 300 mg at night with ranitidine 150 mg twice daily in the treatment of duodenal and gastric ulcer. Am J Gastroenterol 9: 665–668

    Google Scholar 

  24. Bardhan KD (1981) Medical treatment of duodenal ulcer: a review. Trop Gastroenterol 2: 4–33

    Google Scholar 

  25. Gitlin N, McCullough AJ, Smith JL, Mantell G, Berman R et al. (1987) A mulitcenter, doubleblind, randomized, placebo-controlled comparison of nocturnal and twice-a-day famotidine in the treatment of active duodenal ulcer disease. Gastroenterology 92: 48–53

    PubMed  CAS  Google Scholar 

  26. Hartmann H, Fölsch UR (1988) Famotidine versus Cimetidine in the treatment of acute duodenal ulcer. Digestion 39: 156–161

    Article  PubMed  CAS  Google Scholar 

  27. Rohner HG, Gugler R (1986) Treatment of active duodenal ulcers with famotidine. A double-blind comparison with ranitidine. Am J Med 81 [Suppl. 4B]: 13–16

    Google Scholar 

  28. Gray GR, Smith IS, McKenzie I, Gillespie G (1977) Long term Cimetidine in the management of severe duodenal ulcer dyspepsia. Gastroenterology 74:397–401

    Google Scholar 

  29. McGuigan (1981) A consideration of the adverse effects of Cimetidine. Gastroenterology 80: 181–192

    PubMed  CAS  Google Scholar 

  30. Powell JR, Donn KH (1983) The pharmacokinetic basis of H2-antagonist drug interactions: concepts and implications. J Clin Gastroenterol 5: 95–113

    Article  PubMed  Google Scholar 

  31. Hammer R, Berrie CP, Birdsall NJM, Burgen ASV, Hulme EC (1980) Pirenzipine distinguishes between different subclasses of muscarinic receptors. Nature 283: 90–92

    Article  PubMed  CAS  Google Scholar 

  32. Barbara L, Belsasso E, Bianchi-Porro G et al. (1979) Pirenzipine in duodenal ulcer. A multicentre double-blind controlled clinical trial: second of two parts. Scand J Gastroenterol 14 [Suppl. 57]: 33–39

    Google Scholar 

  33. Van Deventer GM, Schneidman D, Walsh JH (1985) Sucralfate and Cimetidine as single agents and in combination for treatment of active duodenal ulcers. A double-blind, placebo-controlled trial. Am J Med 79 [Suppl. 2C]: 39–44

    Google Scholar 

  34. Blum AL, Bode JC, Manegold BC, Domschke W, Feurle G, Hammer B, Hackenberg K (1986) Therapie des Ulcus ventriculi mit Sucralfat und Ranitidin. Dtsch Med Wochenschr 111: 1910–1915

    Article  PubMed  CAS  Google Scholar 

  35. Marks IN, Wright JP, Gilinksy NH, Girwood AH, Tobias R, Boyd E, Kalvaria I (1986) A comparison of sucralfate dosage schedule in duodenal ulcer healing. J Clin Gastroenterol 8: 419–423

    Article  PubMed  CAS  Google Scholar 

  36. Pai S, Melethil S, Cuddy P, Hall T (1987) Elevation of serum aluminium in humans on a two-day sucralfate regimen. J Clin Pharmacol 27: 213–215

    Article  PubMed  CAS  Google Scholar 

  37. Peskar BM, Hoppe U, Lange K, Peskar BA (1988) Effects of non-steroi-dal anti-inflammatory drugs on rat gastric mucosal leukotriene C4 and prostanoid release: relation to ethanol-induced injury. Br J Pharmacol 93:937–943

    Article  PubMed  CAS  Google Scholar 

  38. Tytgat GNJ (1987) Colloidal bismuth subcitrate in peptic ulcer -a review. Digestion 37 [Suppl. 2]: 31–41

    Google Scholar 

  39. Lane MR, Lee SP (1988) Recurrence of duodenal ulcer after medical treatment. Lancet I: 1147–1149

    Google Scholar 

  40. Robert A (1979) Cytoprotection by prostaglandins. Gastroenterology 77: 761–767

    PubMed  CAS  Google Scholar 

  41. Hawkey CJ, Walt RP (1986) Prostaglandins for peptic ulcer: a promise unfulfilled. Lancet II: 1084–1086

    Google Scholar 

  42. Clissold SP, Campoli-Richards DM (1986) Omeprazol: a preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in peptic ulcer disease and Zollinger-Ellison syn drome. Drugs 32: 15–47

    Article  PubMed  CAS  Google Scholar 

  43. Naesdal J, Lind T, Bergsäker-Aspöy J, Bernklev T, Farup PG, Gillberg R, Halvorsen L (1985) The rate of healing of duodenal ulcers during omeprazole treatment. Scand J Gastroenterol 20: 691–695

    Article  PubMed  CAS  Google Scholar 

  44. Walan A, Bader JP, Classen M, Lamers C, Piper DW, Rutgersson K, Eriksson S (1989) Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer. N Engl J Med 320: 69–75

    Article  PubMed  CAS  Google Scholar 

  45. Classen M, Dammann HG, Domschke W, Hengels KJ, Hüthemann W, Londong W, Rehner M (1985) Kurzzeittherapie des Ulcus duodeni mit Omeprazol und Ranitidin. Dtsch Med Wochenschr 110: 210–215

    Article  PubMed  CAS  Google Scholar 

  46. Tytgat GNJ, Lamers CBHW, Hameeteman W, Jansen JMBJ, Wilson JA (1987) Omeprazole in peptic ulcers resistant to histamine H2-receptor antagonists. Aliment Pharmacol Ther 1: 31–36

    Article  PubMed  CAS  Google Scholar 

  47. Haven N (1986) Enterochromaffin like cell carcinoids of gastric mucosa in rats after life long inhibiton of gastric secretion. Digestion 35 [Suppl. 1]: 42–55

    Google Scholar 

  48. Lanzon-Miller S, Pounder RE, Hamilton MR et al. (1987) Twentyfour-hour intragastric acidity and plasma gastrin concentration before and during treatment with either ranitidine or omeprazole. Aliment Pharmacol Ther 1: 239–251

    Article  PubMed  CAS  Google Scholar 

  49. Lamberts R, Creutzfeldt W, Stöckmann F, Jacubaschke U, Maas S, Brunner G (1988) Long-term omeprazole treatment in man: effects on gastric endocrine cell populations. Digestion 39: 126–135

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Medizinische Klinik und Poliklinik, Robert-Koch-Straße 40, 3400, Göttingen, Deutschland

    Prof. Dr. med. Ulrich R. Fölsch

  2. Medizinische Klinik, Städtische Krankenanstalten Rosenhöhe, 4800, Bielefeld 14, Deutschland

    Prof. Dr. med. Ulrich Junge

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  1. Prof. Dr. med. Ulrich R. Fölsch
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  2. Prof. Dr. med. Ulrich Junge
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© 1990 Springer-Verlag Berlin Heidelberg

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Fölsch, U.R., Junge, U. (1990). Ulkuskrankheit. In: Medikamentöse Therapie in der Gastroenterologie. Kliniktaschenbücher. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87466-6_8

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  • DOI: https://doi.org/10.1007/978-3-642-87466-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51886-0

  • Online ISBN: 978-3-642-87466-6

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