Abstract
Protein inhibitors of proteolytic enzymes are widely distributed in nature[1, 2]. Of great interest are those present in pancreatic tissue and in pancreatic secretion. It seems that the pancreatic inhibitors have an important physiological role of protecting the pancreatic tissue from a premature activation of the zymogens which could lead to destruction of the pancreas. Two major types of protein inhibitors have been found in various mammalian pancreases: the basic pancreatic trypsin inhibitor (Kunitz) [3] and the acidic inhibitor (Kazal) which is also called the secretory pancreatic inhibitor [4].
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References
Vogel, R., Trautschold, J., Werle, E.: In: Natural Proteinase Inhibitors. New York-London: Academic Press 1968.
Kassel, B.: Methods Enzymol 19, 839 (1970).
Kassel, B.: Methods Enzymol. 19, 844–852 (1970).
Burck, P.J.: Methods Enzymol. 19, 906–914 (1970).
Haverback, B.J., Dyce, B., Bundy, H., Edmondson, H.A.: Amer. J. Med. 29, 424–433 (1960).
Fritz, H., Woitinas, F, Werle, E.: Z. physiol. Chem. 345, 168–180 (1966).
Keller, P. J, Allen, B.J.: J. biol. Chem. 242, 281–287 (1967).
Fritz, H., Muller, L, Wiedemann, M., Werle, E.: Z. physiol. Chem. 348, 405–418 (1967).
Greene, L.J., Pubols, M.H.: In: Fritz, H., Tschesche, H. (Eds.): Proceedings of the International Research Conference on Proteinase Inhibitors, pp. 196–200. Berlin-New York: Walter de Gruyter 1971.
Feinstein, G., Hoffstein, R., Koifman, Y., Sokolovsky, M.: Europ. J. Biochem. 43, 569–581 (1974).
Feeney, R.E., Osuga, D.T., Maeda, H.: Arch, biochem. Biophys. 119, 124–132 (1967).
Tomimatsu, Y., Clary, J.J., Bartulovich, J.J.: Arch, biochem. Biophys. 115, 536–544 (1966).
Cuatrecasas, P., Wilchek, M., Anfinsen, C: Proc. nat. Acad. Sci (Wash.) 61, 635–643 (1968).
Feinstein, G.: FEBS Letters 7, 353–355 (1970).
Ako, H., Foster, R.J., Ryan, C.A.: Biochem. biophys. Res. Commun. 47, 1402–1407 (1972).
Hummel, B.C. W.: Canad. J. Biochem. 37, 1393–1399 (1959).
Schwert, G. W., Takenaka, Y.: Biochim. biophys. Acta (Amst.) 16, 570–575 (1955).
Gertler, A., Hofmann, T.: Canad. J. Biochem. 48, 384–388 (1970).
Schachman, H.K.: Methods Enzymol. 4, 32–103 (1957).
Vesterberg, O., Svenson, H.: Acta chem. scand. 20, 820–834 (1966).
Davis, G.: Ann. N.Y. Acad. Sci. 121, 404–427 (1964).
Kassell, B., Radicevic, M., Berlow, S., Peanasky, R.J., Laskowski, M., Sr.: J. biol. Chem. 238, 3274–3279 (1963).
Greene, L. J., Rigbi, M, Fackre, D.S.: J. biol. Chem. 241, 5610–5618 (1966).
Kazal, L.A, Spicer, D.S., Brahinsky, R.A.: J. Amer. chem. Soc. 70, 3034–3036 (1948).
Greene, L.J., Dicarlo, J.J., Sussman, A.J., Bartlet, D.C: J. biol. Chem. 243, 1804–1815 (1968).
Tschesche, H., Wachter, E., Kupfer, S., Niedermeir, K.: Z. physiol. Chem. 350, 1247–1256 (1969).
Feinstein, G., Gertler, A.: Europ. J. Biochem. 31, 25–31 (1972).
Feeney, R.E., Means, G.E, Bigler, J.C: J. biol. Chem. 244, 1957–1960 (1969).
Coan, M.H., Travis, J.: In: Fritz, H., Tschesche, H. (Eds.): Proceedings of the International Research Conference on Proteinase Inhibitors, pp. 294–298. Berlin-New York: Walter de Gruyter 1971.
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Feinstein, G., Hoffstein, R., Sokolovsky, M. (1974). Isolation of Human Pancreatic Inhibitor and the Study of Its Interaction with Mammalian and Human Proteases. In: Fritz, H., Tschesche, H., Greene, L.J., Truscheit, E. (eds) Proteinase Inhibitors. Bayer-Symposium, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87966-1_24
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DOI: https://doi.org/10.1007/978-3-642-87966-1_24
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