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Biologische Grundfragen bei der homokontinuierlichen Kultur von Mikroorganismen

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Ergebnisse der Biologie

Part of the book series: Ergebnisse der Biologie Advances in Biology ((ERGBIOL,volume 25))

Zusammenfassung

Die Methode der kontinuierlichen Kultur von Mikroorganismen hat in dem vergangenen Jahrzehnt auf verschiedenen Gebieten der Mikrobiologie zu neuen Ergebnissen geführt. Es hat sich gezeigt, daß bei mikrobiologischen Untersuchungen die Kulturbedingungen, ihre Konstanz oder Veränderlichkeit, für alle stoffwechselphysiologischen Vorgänge von grundsätzlicher Bedeutung sind. Durch die experimentell erzielte Konstanz aller Faktoren im homokontinuierlichen System verliert die Kultur ihr physiologisches Alter. Sie wurde damit komplizierteren stoffwechselphysiologischen und -regulatorischen Experimenten zugänglich. Zugleich lieferte der evolutionistische Charakter der Populationsdynamik in kontinuierlicher Kultur eine neue Basis für genetische Untersuchungen.

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Literatur

  • Abbo, F. E., and A. B. Pardee: Synthesis of macromolecules in synchronously dividing bacteria. Biochim. biophys. Acta (Aust.) 39, 478–485 (1960).

    Article  CAS  Google Scholar 

  • Abson J. W. and K. H. Todhunter: Plant for continuous biological treatment of carbonisation effluents. In: Soc. Chem. Ind. Monograph No. 12 S. 147–164 London 1961

    Google Scholar 

  • Andreev, K. P.: Use of continuous culture method for alcoholic fermentation of mashes of soft wood hydrolysate. In: Cont. Cult. of Microorg., A Symposium S. 186–197, Prag 1958.

    Google Scholar 

  • Atwood, K. C., L. K. Schneider and F. J. Ryan: Selective mechanisms in bacteria. Cold Spr. Harb. Symp. quant. Biol. 16, 345–355 (1951).

    Article  CAS  Google Scholar 

  • Bauchop, T., and S. R. Elsden: The growth of micro-organisms in relation to their energy supply. J. gen. Microbiol. 23, 457–469 (1960).

    PubMed  CAS  Google Scholar 

  • Beran K.: Continuous flow cultivation of bakers yeast on beet molasses wort. In: Cont. Cult. of Microorg. A Symposium S. 122–156 Prag 1958

    Google Scholar 

  • Bernhauer, K.: Die oxydativen Gärungen. Berlin: J. Springer 1932.

    Book  Google Scholar 

  • Braun, W.: Bacterial Genetics. Philadelphia: W. Saunders Comp. 1953.

    Google Scholar 

  • Bryson, V.: Microbial selection. Part II. The turbidostatic selector — a device for automatic isolation of bacterial variants. Science 116, 48–51 (1952).

    Article  Google Scholar 

  • Bryson, V.: Applications of continuous culture to microbial selection. 7. Int. Congr. Microbiol., S. 371–380, Stockholm 1958.

    Google Scholar 

  • Buchanan, R. L.: Life phases in a bacterial culture. J. infect. Dis. 23, 109–125 (1918).

    Google Scholar 

  • Burton, A. C.: The basis of the principle of the master reaction in biology. J. cell. comp. Physiol. 9, 1 (1936).

    Article  Google Scholar 

  • Callow, D. S., and S. J. Pirt: A two-stage continuous culture apparatus. J. appl. Bact. 22, ii (1959).

    Google Scholar 

  • Capbell, A.: Synchronization of cell division. Bact. Rev. 21, 263–272 (1957).

    Google Scholar 

  • Cohen-Bazire, G., W. R. Sistrom and R. Y. Stanier: Kinetic studies of pigment synthesis by non-sulfur purple bacteria. J. cell. comp. Physiol. 49, 25–68 (1957).

    Article  CAS  Google Scholar 

  • Cohn, M., and J. Monod: Specific inhibition and induction of enzyme biosynthesis. In: Symp. Soc. gen. Microbiol. 3, 132–147 (1953).

    Google Scholar 

  • Dagley, S. and C. N. Hinshelwood: Physiochemical aspects of bacterial growth. Part II. Quantitative dependence of the growth rate of Bact. lactis aerogenes on the carbon dioxide content of the gas atmosphere. J. chem. Soc. 1938, 1936–1942.

    Google Scholar 

  • Danckwerts, P. V.: Continuous flow of materials through processing units. Ind. chem. Mfr. 30, 102 (1954).

    CAS  Google Scholar 

  • De Haan, P. G., and K. C. Winkler: Phage reproduction in relation to bacterial growth rate. Antonie v. Leeuwenhoek 21, 103–112 (1955).

    Article  Google Scholar 

  • Drews, G.: Untersuchungen zur Substruktur der „Chromatophoren“ von Rhodo-spirillum rubrum und Rhodospirillum molischianum. Arch. Mikrobiol. 36, 99–108 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Ecker, R. E., and W. R. Lockhart: Influence of initial population of the length of lag. Bact. Proc. 1960, 165.

    Google Scholar 

  • Elsworth, R., R. C. Telling and D. N. East: The investment value of continuous culture. J. appl. Bact. 22, 138–152 (1959).

    Article  Google Scholar 

  • Foster, J. W.: Chemical activities of fungi. S. 164–169. New York: Academic Press 1949.

    Google Scholar 

  • Frencl Z. and M. Burger: Some aspects of continuous culture of food yeast. In: Cont. Cult. of Microorg. A Symposium S. 165–173 Prag 1958

    Google Scholar 

  • Frenkel, A. W., and D. D. Hickmann: Structure and photochemical activity of chlorophyll containing particles from Rhodospirillum rubrum. J. biophys. bio-chem. Cytol. 6, 285 (1959).

    Article  CAS  Google Scholar 

  • Gale, E. F.: Factors influencing the enzymic activities of bacteria. Bact. Rev. 7, 139–173 (1943).

    PubMed  CAS  Google Scholar 

  • Gerhardt, P., and M. C. Bartlett: Continuous industrial fermentations. In: Advanc. appl. Microbiol. 1, 215–260 (1959).

    Article  CAS  Google Scholar 

  • Gorini, L.: Antagonism between substrate and repressor in controlling the formation of a biosynthetic enzyme. Proc. nat. Acad. Sci. (Wash.) 46, 682–690 (1960).

    Article  CAS  Google Scholar 

  • Gorini, and W. K. Maas: The potential for the formation of a biosynthetic enzyme in Escherichia coli. Biochim. biophys. Acta (Amst.) 25, 208–209 (1957).

    Article  CAS  Google Scholar 

  • Gould, G. W., and H. Lees: The isolation and culture of the nirifying organisms. Can. J. Microbiol. 6, 299–307 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Henrici, A. T.: Morphologic variation and the rate of growth of bacteria. London: Baillière, Tindall u. Cox 1928.

    Book  Google Scholar 

  • Herbert D.: Some principles of continuous culture. 7. Int. Congr. Microbiol. Symp. S. 381–396 Stockholm 1958

    Google Scholar 

  • Herbert, D.: Discussion part of the symposium on the continuous cultivation of microorganisms held in Praha in June 1958, S. 391-392. Folia microbiol. (Praha) 4, 390–408 (1959).

    Article  Google Scholar 

  • Herbert, D.: A theoretical analysis of continuous culture systems. In: Soc. Chem. Ind. Monogr. No. 12, S. 21–53, London 1961.

    Google Scholar 

  • Herbert, D.: The chemical composition of micro-organisms as a function of their environment. In: Symp. Soc. gen. Microbiol. 11, 391–416 (1961a).

    Google Scholar 

  • Herbert, R. Elsworth and R. C. Telling: The continuous culture of bacteria: a theoretical and experimental study. J. gen. Microbiol. 14, 601–622 (1956).

    PubMed  CAS  Google Scholar 

  • Hershey, A. D.: Factors limiting bacterial growth. IV. The age of the parent culture and the rate of growth of transplants of Escherichia coli. J. Bact. 37, 285–299 (1939).

    CAS  Google Scholar 

  • Hinshelwood, C. N.: The chemical kinetics of the bacterial cell. Oxford: Clarendon Press 1946.

    Google Scholar 

  • Holme, T.: Glycogen formation in continuous culture of Escherichia coli B. In: Cont. Cult. of Microorg. A. Symp. S. 67–74, Prag 1958.

    Google Scholar 

  • James, T. W.: Continuous culture of microorganisms. Ann. Rev. Microbiol. 15, 27–46 (1961).

    Article  Google Scholar 

  • Jannasch, H. W.: Bacterial growth at low population densities. Nature (Lond.) (1962) (im Druck).

    Google Scholar 

  • Jannasch, H. W.: Studies on the ecology of a marine Spirillum in the chemostat. 1. Int. Symp. Mar. Microb. Springfield, Ill: C. C. Thomas Publ., 1962(a).

    Google Scholar 

  • Karström, H.: Über die Enzymbildung in Bakterien. Thesis, Helsinki 1930.

    Google Scholar 

  • Kjeldgaard, N. O., O. MAALø Schaechter: The transition between different physiological stages during balanced growth of Salmonella typhimurium. J. gen. Microbiol. 19, 607–616 (1958).

    PubMed  CAS  Google Scholar 

  • Knaysi, G.: Elements of bacterial cytology. Ithaca, N. Y.: Comstock Publ. Comp Ithaca, N. Y. Second Ed., 19

    Google Scholar 

  • Lamanna, C., and M. F. Mallette: Basic Bacteriology. Baltimore: Williams & Wilkins Comp. Second Ed., 1959.

    Google Scholar 

  • Lark, K. G.: Studies on the mechanism regulating periodic DNA-synthesis in synchronized cultures of Alcaligenes fecalis. Biochim. biophys. Acta (Amst.) 45, 121–132 (1960).

    Article  CAS  Google Scholar 

  • Lee, H. H.: The mutation of E. coli to resistance to bacteriophage T6. Arch. Biochem. 47, 438–444 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Liebmann, A. J., and Debecze, G. I.: U.S.-Patent 2524200 (1950). In: Advanc. appl. Microbiol. 1, 215–260 (1959).

    Article  Google Scholar 

  • Lodge, R. M., and C. N. Hinshelwood: Physicochemical aspects of bacterial growth. Part IX. The lag phase of Baot lactis aerogenes. J. chem. Soc. 1943, 213–219

    Google Scholar 

  • Lumb M. and G. D. Wilkin: Industrial applications of continuous culture processes. In: Soc. Chem. Ind. Monogr. No 12 S. 254–264 London 1961

    Google Scholar 

  • Maaløe, O.: The nucleic acids and the control of bacterial growth. In: Symp. Soc. gen. Microbiol. 10, 272–293 (1960).

    Google Scholar 

  • Maclean, F. J., and R. J. Munson: Some environmental factors affecting the length of Escherichia coli organisms in continuous culture. J. gen. Microbiol. 25, 17–27 (1961).

    PubMed  CAS  Google Scholar 

  • Macura, I.: Continous flow method in soil microbiology. Fol. Microbiol. 6, 328–334 (1961).

    Article  CAS  Google Scholar 

  • Magasanik, B.: Nutrition of bacteria and fungi. Ann. Rev. Microbiol. 11, 221–252 (1957).

    Article  CAS  Google Scholar 

  • Magasanik B.: A. K. Magasanik and F. C. Neidhardt: Regulation of growth and composition of the bacterial cell. In: Ciba Found. Symp. on the regulation of cell metabolism S. 334–349 London 1959

    Google Scholar 

  • Malek, I.: The physiological state of microorganisms during continuous culture. In: Continuous cultivation of microorganisms. A Symposium, S. 11–28, Acad. of Sci., Prag 1958.

    Google Scholar 

  • Malek, I.: Development and further perspective of the continuous-flow method of cultivation of microorganisms. In: Soc. Chem. Ind. Monogr. No 12, S. 3–20, London 1961.

    Google Scholar 

  • Malek, and Z. Fencl: Continuous cultivation of microorganisms. Folia microbiol. (Praha) 6, 192–209 (1961).

    Article  Google Scholar 

  • Mason, D. R., and E. L. Piret: Continuous flow stirred tank reactor system. Development of transient equations. Ind. Eng. Chem. 42, 817–825 (1950).

    CAS  Google Scholar 

  • Matales, R. J., and G. J. Fuld: Continuous hydroxylation of prodesterone by Aspergillus ochraceus. Antonie v. Leeuwenhoek 27, 33–50 (1961).

    Article  Google Scholar 

  • Maxon, W. D.: Continuous fermentation: A discussion of its principles and applications. Appl. Microbiol. 3, 110–122 (1955).

    PubMed  CAS  Google Scholar 

  • Maxon, and M. J. Johnson: Aeration studies on propagation of bakers yeast. Ind. Eng. Chem. 45, 2554–2556 (1953).

    Article  CAS  Google Scholar 

  • Monod, J.: The growth of bacterial cultures. Ann. Rev. Microbiol. 3, 371–394 (1949).

    Article  CAS  Google Scholar 

  • Monod, J.: La technique de culture continue; theorie et applications. Ann. Inst. Pasteur 79, 390–410 (1950).

    CAS  Google Scholar 

  • Monod, J.: Recherches sur la croissance des cultures bactériennes. Thèse de 1942, 2. Ed. Paris: Hermann 1958.

    Google Scholar 

  • Monod, J.: Biosynthese eines Enzyms. Angew. Chem. 71, 685–708 (1959).

    Article  CAS  Google Scholar 

  • Moser, H.: The dynamics of bacterial populations maintained in the chemostat. Carnegie Inst. of Wash. Publ. 614, Wash. D.C. (1958).

    Google Scholar 

  • Myers, I., and L. B. Clark: Culture conditions and development of the photo-synthetic mechanism. II. An apparatus for the continuous culture of Chlorella. J. gen. Physiol. 28, 103–112 (1944).

    CAS  Google Scholar 

  • Neidhardt, F. C.: Mutant of Aerobacter aerogenes lacking glucose repression. J. Bact. 80, 536–543 (1960).

    PubMed  CAS  Google Scholar 

  • Neumann, F.: Die Sichtbarmachung von Bakteriengeißeln am lebenden Objekt im Dunkelfeld. II. Mitt. Zbl. Bakt., I. Abt. Orig. 109, 143–180 (1928)

    CAS  Google Scholar 

  • Niklowitz, W., u. G. Drews: Zur elektronenmikroskopischen Darstellung der Feinstruktur von Rhodospirillum rubrum. Arch. Mikrobiol. 23, 123–129 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Novick, A.: Growth of bacteria. Ann. Rev. Microbiol. 9, 97–110 (1955).

    Article  CAS  Google Scholar 

  • Novick, A.: Genetic and physiological studies with the chemostat. In: Cont. Cult. of Micro-org. A Symposium, S. 29–44, Acad. Sci., Prag 195

    Google Scholar 

  • Novick, A.: Experimentation with the chemostat. 7. Int. Congr. Microbiol. Symp. S. 403 bis 415, Stockholm 1958(b).

    Google Scholar 

  • Novick, A.: Discussion part of the symposium on the continuous cultivation of microorganisms held in Praha in June 1958, S. 395-398. Folia microbiol. (Praha) 4, 390–408 (1959).

    Article  Google Scholar 

  • Novick, and L. Szilard: Description of the chemostat. Science 112, 715–716 (1950).

    Article  PubMed  CAS  Google Scholar 

  • Novick, and L. Szilard: Experiments with the chemostat on spontaneous mutations of bacteria. Proc. nat. Acad. Sci. (Wash.) 36, 708–719 (1950a).

    Article  CAS  Google Scholar 

  • Novick, and L. Szilard: Genetic mechanisms in bacteria and bacterial viruses, I. Cold Spr. Harb. Symp. quant. Biol. 16, 337–343 (1951).

    Article  CAS  Google Scholar 

  • Novick, and L. Szilard: Dynamics of growth processes. S. 21–32. Princeton, N.Y.: Princeton Univ. Press Princeton, N.Y 1954

    Google Scholar 

  • Novick, and M. Weiner: Enzyme induction as an all-or-none phenomenon. Proc. nat. Acad. Sci. (Wash.) 43, 533–566 (1957).

    Article  Google Scholar 

  • Olsen, A. J. C.: Manufacture of bakers yeast by continuous fermentation, I. Plant and process. In: Soc. Chem. Ind. Monogr. No. 12, S. 81–93, London 19

    Google Scholar 

  • Palmer, F. E., and E. J. Ordal: Steady state enrichment cultures of aquatic and marine microorganisms. Bact. Proc. 1961, 45.

    Google Scholar 

  • Pardee A. B.: Mechanisms for control of enzyme synthesis and enzyme activity in bacteria. In: Ciba Found. Symp. on the regulation of cell metabolism S. 295–304 London 1959

    Google Scholar 

  • Pardee, A. B.: Response of enzyme synthesis and activity of environment. In: Symp. Soc. gen. Microbiol. 11, 19–40 (1961).

    Google Scholar 

  • Perret, C. J.: Penicillinase adaptation in multiplying cultures of Bacillus cereus maintained at constant population density. Riassunti Communicazioni, VI. Congr. Intern. Microbiol. I, 153–154, Rom 1953.

    Google Scholar 

  • Perret, C. J.: A new kinetic model of a growing bacterial population. J. gen. Microbiol. 22, 589–617 (1960).

    CAS  Google Scholar 

  • Pipes, W. O., and S. P. Koutsoyannis: Light-limited growth of Chlorella in con-tinous cultures. Appl. Microbiol. 10, 1–5 (1962).

    PubMed  CAS  Google Scholar 

  • Pirt, S. J., and D. S. Callow: Exocellular product formation by microorganisms in continuous culture. I. Production of 2,3-Butanediol by Aerobacter aerogenes in a single stage process. J. appl. Bact. 21, 188–205 (1958).

    Article  CAS  Google Scholar 

  • Pirt, S. J., and D. S. Callow: The growth of Pénicillium chrysogenum in continuous culture. J. appl. Bact. 22, ii (1959).

    Google Scholar 

  • Pirt, S. J., and D. S. Callow: Studies of the growth of Penicillium chrysogenum in continuous flow culture with reference to penicillin production. J. appl. Bact. 23, 87–98 (1960).

    Article  Google Scholar 

  • Pollock, M. R.: Stages in enzyme adaptation. In: Symp. Soc. gen. Microbiol. 3, 150–177 (1953).

    Google Scholar 

  • Powell, E. O.: Growth rate and generation time of bacteria, with special reference to continuous culture. J. gen. Microbiol. 15, 492–511 (1956).

    PubMed  CAS  Google Scholar 

  • Powell, E. O.: Criteria for growth of contaminants and mutants in continuous culture. J. gen. Microbiol. 18, 259–268 (1958).

    PubMed  CAS  Google Scholar 

  • Powell, E. O.: Diskussion, 7. Int. Congr. Microbiol. S. 422–423. Stockholm 1958a.

    Google Scholar 

  • Preusser, H.-J.: Licht-und elektronenmikroskopische Untersuchungen über die Begeißelung von Proteus vulgaris. Arch. Mikrobiol. 29, 1–16 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Reusser, F.: Theoretical design of continuous antibiotic fermentation units. Appl. Microbiol. 9, 361–366 (1961).

    PubMed  CAS  Google Scholar 

  • Ricica J.: Continuous culture techniques. In: Continuous cultivation of microorganisms. A Symposium S. 75–105 Acad. of Sci. Prag 1958

    Google Scholar 

  • Rogers, H. J.: The rate of formation of hyaluronidase, coagulase and total extracellular protein by strains of Staphylococcus aureus. J. gen. Microbiol. 10, 209–220 (1954).

    PubMed  CAS  Google Scholar 

  • Rosenberger, R. F., and S. R. Elsden: The yields of Streptococcus faecalis grown in continuous culture. J. gen. Microbiol. 22, 726–739 (1960).

    PubMed  CAS  Google Scholar 

  • Schaechter, M., O. MAALøE and N. O. Kjeldgaard: Dependency on medium and temperature of cell size and chemical composition during balanced growth of Salmonella typhimurium. J. gen. Microbiol. 19, 592–606 (1958).

    PubMed  CAS  Google Scholar 

  • Schmidt, R. R., and K. W. King: Metabolic shifts during synchronous growth of Chlorella pyrenoidosa. Biochim. biophys. Acta (Amst.) 47, 391–392 (1961).

    Article  CAS  Google Scholar 

  • Sikyta, S., J. Slezak and M. Herold: Growth of Streptomyces aureofaciens in continuous culture. Appl. Microbiol. 9, 233–238 (1961).

    PubMed  CAS  Google Scholar 

  • Skerman, V. B. D., and I. C. Macrae: The influence of oxygen on the formation of nitratase in Pseudomonas denitrificans. Canad. J. Microbiol. 7, 169–174 (1961).

    Article  CAS  Google Scholar 

  • Stewart, D. G., R. G. Warner U. H. W. Seeley: Continuous culture as a method for studying rumen fermentations. Appl. Microbiol. 9, 150–156 (1961).

    PubMed  CAS  Google Scholar 

  • Suomalainen, H., and E. Oura: Increase of saccharase content in bakers yeast during the growth phase. Arch. Biochem. 68, 425–431 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Suomalainen, S. Pfäffli and E. Oura: The saccharase activity of bakers yeast in relation to its mannan content. Suom. Kemistilethi B 33, 205 (1960).

    Google Scholar 

  • Van Niel, C. B.: The chemoautotrophic and photosynthetic bacteria. Ann. Rev. Microbiol. 8, 105–132 (1954).

    Article  Google Scholar 

  • Tamiya, H.: Mass culture of algae. Ann. Rev. Plant Physiol. 8, 309–334 (1957).

    Article  CAS  Google Scholar 

  • Vogel, H. J.: Repression and induction as control mechanisms of enzyme biogenesis: The “adaptive” formation of acetyl-ornithinase. In: Symp. on the Chemical Basis of Heredity, S. 276–289, Baltimore: Johns Hopkins Press 195

    Google Scholar 

  • Wade, H. E.: Observations on the growth phases of Escherichia coli, American type “B”. J. gen. Microbiol. 7, 18–23 (1952).

    PubMed  CAS  Google Scholar 

  • Wade, H. E.: Variation on the phosphorous content of Escherichia coli during cultivation. J. gen. Microbiol. 7, 24–30 (1952 a).

    PubMed  CAS  Google Scholar 

  • Warner, A. C. I.: The actual nitrogen sources for growth of heterotrophic bacteria in non-limiting media. Biochem. J. 64, 1–6 (1956).

    PubMed  CAS  Google Scholar 

  • Williamson, D. H., and A. W. Scopes: Synchronization of division in cultures of Saccharomyces cerevisiae by control of the environment. In: Symp. Soc. gen. Microbiol. 11, 217–242 (1961).

    Google Scholar 

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H. Autrum E. Bünning K. v. Frisch E. Hadorn A. Kühn E. Mayr A. Pirson J. Straub H. Stubbe W. Weidel Hansjochem Autrum

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Pfennig, N., Jannasch, H.W. (1962). Biologische Grundfragen bei der homokontinuierlichen Kultur von Mikroorganismen. In: Autrum, H., et al. Ergebnisse der Biologie. Ergebnisse der Biologie Advances in Biology, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-94837-4_4

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