Skip to main content
SpringerLink
Log in

Forschungsschwerpunkt Biologische Grundlagen der Tumortherapie

  • Chapter
Krebsforschung heute

  • 22 Accesses

Zusammenfassung

So unbestritten die Erfolge von „Stahl und Strahl“ in der modernen Krebstherapie sind, so bescheiden erscheinen die Erfolge der Chemotherapie maligner Tumoren. Wie kommt es zu diesem Nachholbedarf?

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Baron, S., and Buckler, C. E.: Circulating interferon in mice after intravenous injection of virus. Science 141, 1061–1063 (1963)

    Article  PubMed  CAS  Google Scholar 

  • Bloom, B. R.: Interferons and the immune system. Nature 284, 593–595 (1980)

    Article  PubMed  CAS  Google Scholar 

  • Borden, E. C: Interferon: Rationale for clinical trials in neoplastic disease Annals Int. Med. 91, 472–479 (1979)

    CAS  Google Scholar 

  • Derynck, R., Content, J. De Clerg, E., Volckart G., Tavernier J., Davos, R. and Fiers, W.: Isolation and structure of a human fibroblast interferon gene. Nature 285, 542–546 (1980)

    Article  PubMed  CAS  Google Scholar 

  • Derynck, R., Remaut, E., Saman, E., Staussens, P., De Clercq, E., Content, J. and Fiers, W.: Expression of human fibroblast interferon gene in Escherichia coli. Nature 287, 193–197 (1980)

    Article  PubMed  CAS  Google Scholar 

  • Dunnick, J. K. and Galasso, G. J.: Clinical trials with exogenous interferon: Summary of a meeting. J. Infect. Bis. 139, 109–123 (1979)

    Article  CAS  Google Scholar 

  • Gresser, I. and Bourali, Ch.: Antitumor effects of interferon preparations in mice. J. Natl. Cancer Inst. 45, 365–376

    Google Scholar 

  • Gresser, I.: Antitumor effects of interferon. Biochim Biophys. Acta 516, 231–247 (1978)

    PubMed  CAS  Google Scholar 

  • Gutterman, J. Yap, Y. Buzdar, A. Alexanian, R. Hersh, E.: Leucocyte interferon induced tumor regression in patients with breast cancer and B cell neoplasms. Proceedings of the American Association for Cancer Research and American Society of Clinical Oncology. Baltimore: Waverly Press 20, 167 (1979)

    Google Scholar 

  • Heron, I., Hokland, M. and Berg, K.: Enhanced expression of β2-micro-globulin and HLA antigens on human lymphoid cells by interferon. Prcc. Natl. Acad. Sci. USA 75, 6215–6219 (1978)

    Article  CAS  Google Scholar 

  • Hirsch, M. S. and Swartz, M. N.: Antiviral agents (Second of two parts) New Engl. J. Med. 302, 949–953 (1980)

    CAS  Google Scholar 

  • Issacs A., and Lindenmann, J.: Virus interference I. Interferon Proc. Royal soc. London Section B 147, 285–267 (1957)

    Google Scholar 

  • Masuci, M. G., Szigeti, R., Klein, E., Klein, G., Gruest, J., Montagnier, L., Taira, H., Hall, A., Nagata, S., and Weissmann, Ch.: Effect of interferon α-1 from E. coli on some cell functions. (Science, 209, 1431–1435 (1980)

    Article  Google Scholar 

  • Nagata, S., Taira, H., Hall, A., Johnstrud, L., Streuli, M., Escödi, J., Boll, W., Cantell, K. and Weissmann, Ch.: Synthesis in E. coli of a polypeptide with a human leucocyte interferon activity. Nature 284, 316–320 (1980)

    Article  PubMed  CAS  Google Scholar 

  • Nagata, S., Mantei, N. and Weissmann, Ch.: The structure of one of the eight or more distinct chromosomal genes for human interferon. Nature 287, 401–408(1980)

    Article  PubMed  CAS  Google Scholar 

  • Riviere, Y., Gresser, I., Guillon, J. C. and Tovey, M. G.: Inhibition by anti-interferon serum of lymphocytic choriomeningitis virus disease in suckling mice. Proc. Natl. Acad. Sci USA 74, 2135–2139 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Strander, H., and Cantell, K.: Production of interferon by human leucocoyte in vitro. Ann. Med. Exp. Fenn. 44, 265–273 (1966)

    PubMed  CAS  Google Scholar 

  • Stringfellow, D. A., Vanderberg, H.C and Weed, S. D.: Interferon induction by 5-Halo-6-Phenyl pyrimidinones. J. Interferon Res. 1, 1–14 (1980)

    Article  PubMed  CAS  Google Scholar 

  • Tan, Y. H. and Berthold, W.: A mechnism for the induction and regulation of human fibroblastoid interferon genetic expression. J. Gen. Virol. 34, 401–411 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Taniguchi, T., Mantei, N., Schwarzstein, M., Nagata, S., Muramatsu, M., and Weissmann, Ch.: Human leucocyte and fibroblast interferon are structurally related. Nature 285, 547–549 (1980)

    Article  PubMed  CAS  Google Scholar 

  • Wheelock, E. F.: Interferon-like virus-inhibitor induced in human leucocytes byphytohemagglutinin. Science 149, 310–311 (1965)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung Wachstum und Teilung der Zelle, Institut für Zell- und Tumorbiologie, Deutschland

    Prof. Dr. Herwig Ponstingl

  2. Abteilung Immunchemie, Institut für Immunologie und Genetik, Deutschland

    Prov. Doz. Dr. Volker Lehmann

  3. Abteilung Immungenetik, Institut für Immunologie und Genetik, Deutschland

    Dr. Peter Krammer

  4. Abteilung Tumorvirus-Immunologie, Institut für Virusforschung, Deutschland

    Prof. Dr. Holger Kirchner

Authors
  1. Prof. Dr. Herwig Ponstingl
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prov. Doz. Dr. Volker Lehmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dr. Peter Krammer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Prof. Dr. Holger Kirchner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

    Rights and permissions

    Reprints and permissions

    Copyright information

    © 1981 Springer-Verlag GmbH Berlin Heidelberg

    About this chapter

    Cite this chapter

    Ponstingl, H., Lehmann, V., Krammer, P., Kirchner, H. (1981). Forschungsschwerpunkt Biologische Grundlagen der Tumortherapie. In: Krebsforschung heute. Steinkopff. https://doi.org/10.1007/978-3-642-95975-2_6

    Download citation

    • DOI: https://doi.org/10.1007/978-3-642-95975-2_6

    • Publisher Name: Steinkopff

    • Print ISBN: 978-3-7985-0597-1

    • Online ISBN: 978-3-642-95975-2

    • eBook Packages: Springer Book Archive

    Publish with us

    Policies and ethics

    Search

    Navigation