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Intranuclear and Intracytoplasmic Inclusions in Normal and Neoplastic Hepatocytes, Mouse

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Digestive System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

No specific features are seen by gross examination. The inclusions are identified by microscopic examination of tissue sections stained by routine procedures.

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References

  • Andrew W, Brown HM, Johnson JB (1943) Senile changes in the liver of mouse and man, with special reference to the similarity of nuclear alterations. Am J Anat 72: 199–221

    Article  Google Scholar 

  • Cossel L (1979) Der lichtmikroskopische Befund der glo-bularen hyalinen Körper in der menschlichen Leber und seine elektronenmikroskopischen Äquivalente. Zentralbl Allg Pathol 123:479–507

    PubMed  CAS  Google Scholar 

  • Essner E (1967) Ultrastructure of spontaneous hyperplastic nodules in mouse liver. Cancer Res 27:2137–2152

    PubMed  CAS  Google Scholar 

  • Frith CH, Ward JM (1980) A morphologic classification of proliferative and neoplastic hepatic lesions in mice. J Envir Pathol Toxicol 3: 329–351

    Google Scholar 

  • Gellatly JBM (1975) The natural history of hepatic parenchymal nodule formation in a colony of C57BL mice with reference to the effect of diet. In: Butler WH, Newberne PM (eds) Mouse hepatic neoplasia. Elsevier, Amsterdam, chap 5

    Google Scholar 

  • Greenblatt M (1982) Tumours of the liver. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol III. Tumours of the hamster. IARC Sci Publ No 34, Lyon, pp 69–102

    Google Scholar 

  • Guillon JC, Chouroulinkov I, Guerin M (1967) Hepa-tomes de la souris. I. Hepatomes chez une lignée de souris albinos. Pathol Biol (Paris) 15: 241–249

    CAS  Google Scholar 

  • Hollander CF (1975) Embryology and ageing effects. In: Butler WH, Newberne PM (eds) Mouse hepatic neoplasia. Elsevier, Amsterdam, chap 2

    Google Scholar 

  • Hollander CF, Thung PJ (1966) Relations between regenerative growth and aging in the mouse liver. In: Lindop PJ, Sacher GA (eds) Proc Colloquim on radiation and ageing. Taylor and Francis, London, pp 3–14

    Google Scholar 

  • Hruban Z, Swift H, Dunn FW, Lewis DE (1965) Effect of beta-furylalanine on the ultrastructure of the hepato-cytes and pancreatic acinar cells. Lab Invest 14:70–80

    PubMed  CAS  Google Scholar 

  • Hruban Z, Kirsten WH, Slesers A (1966) Fine structure of spontaneous hepatic tumors of male C3H/fGs mice. Lab Invest 15: 576–588

    PubMed  CAS  Google Scholar 

  • Ichikawa A (1965) Fine structural changes in response to hormonal stimulation of the perfused canine pancreas. J Cell Biol 24: 369–385

    Article  PubMed  CAS  Google Scholar 

  • Jamieson JD, Palade GE (1971) Synthesis, intracellular transport, and discharge of secretory proteins in stimulated pancreatic exocrine cells. J Cell Biol 50: 135–158

    Article  PubMed  CAS  Google Scholar 

  • Kanich RE, Craighead JE (1972) Human cytomegalovirus infection of cultured fibroblasts. II. Viral replicative sequence of a wild and an adapted strain. Lab Invest 27: 273–282

    PubMed  CAS  Google Scholar 

  • Lafontaine JG, Allard C (1964) A light and electron microscope study of the morphological changes induced in rat liver cells by the azo dye 2-ME-DAB. J Cell Biol 22: 143–172

    Article  PubMed  CAS  Google Scholar 

  • Leduc EH, Wilson JW (1959 a) A histochemical study of intranuclear inclusions in mouse liver and hepatoma. J Histochem Cytochem 7: 8–16

    Article  PubMed  CAS  Google Scholar 

  • Leduc EH, Wilson JW (1959 b) An electron microscope study of intranuclear inclusions in mouse liver and hepatoma. J Biophys Biochem Cytol 6: 427–430

    Article  PubMed  CAS  Google Scholar 

  • McClure HM, Chapman WL Jr, Hooper BE, Smith FG, Fletcher OJ (1978) The digestive system: liver. In: Bernirschke K, Garner FM, Jones TC (eds) Pathology of laboratory animals, vol I. Springer, New York Heidelberg Berlin, pp 243–275

    Google Scholar 

  • Palade GE (1956) Intracisternal granules in the exocrine cells of the pancreas. J Biophys Biochem Cytol 2: 417–422

    Article  PubMed  CAS  Google Scholar 

  • Schauer A, Kunze E (1976) Tumours of the liver. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol I. Tumours of the rat, part 2. IARC Sci Publ No 6, Lyon, pp 41–72

    Google Scholar 

  • Siekevitz P, Palade GE (1958) A cytochemical study on the pancreas of the guinea pig. II. Functional variations in the enzymatic activity of microsomes. J Biophys Biochem Cytol 4: 309–318

    Article  PubMed  CAS  Google Scholar 

  • Tardini A, Anversa P, Bordi C, Bertaccini G, Impicciatore M (1971) Ultrastructural and biochemical changes after marked caerulein stimulation of the exocrine pancreas in the dog. Am J Pathol 62: 35–56

    PubMed  CAS  Google Scholar 

  • Toth K, Somosy Z, Bence J, Sugar J (1975) Study of globular bodies found in hepatomas of Swiss mice. Z Krebsforsch 84:67–73

    Article  CAS  Google Scholar 

  • Ward JM (1980).Unique toxic lesions induced by chemical carcinogens in rodents: indications of a short-term bio-assay for carcinogenesis testing of environmental chemicals. Med Hypotheses 6:421–425

    Article  PubMed  CAS  Google Scholar 

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© 1985 Springer-Verlag Berlin Heidelberg

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Toth, K., Sugár, J. (1985). Intranuclear and Intracytoplasmic Inclusions in Normal and Neoplastic Hepatocytes, Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Digestive System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96910-2_15

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  • DOI: https://doi.org/10.1007/978-3-642-96910-2_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96912-6

  • Online ISBN: 978-3-642-96910-2

  • eBook Packages: Springer Book Archive

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