Abstract
Diabetic rat kidneys are larger than those of normal rats of corresponding age. The capsular surface is usually smooth. A fine granulation can occur in late stages. The cut surfaces are brownish red.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bell RH Jr, Borjesson BA, Wolf PL, Fernandez-Cruz L, Brimm JE, Lee S, Sayers HJ, Orloff MJ (1984) Quantitative morphological studies of aging changes in the kidney of the Lewis rat. Renal Physiol 7: 176–184
Cohen MP, Klein CV (1979) Glomerulopathy in rats with streptozotocin diabetes. Accumulation of glomerular basement membrane analogous to human diabetic nephropathy. J Exp Med 149: 623–631
Haley DP, Bulger RE (1983) The aging male rat: structure and function of the kidney. Am J Anat 167: 1–13
Hasslacher C, Reichenbacher R, Gechter F, Timpl R (1984) Glomerular basement membrane synthesis and serum concentration of type IV collagen in streptozotocin-diabetic rats. Diabetologia 26: 150–154
Hirose K, Osterby R, Nozawa M, Gundersen HJG (1982) Development of glomerular lesions in experimental long-term diabetes in the rat. Kidney Int 21: 689–695
Hostetter TH, Troy JL, Brenner BM (1981) Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int 19: 410–415
Jensen PK, Sandahl Christiansen J, Steven K, Parving HH (1981) Renal function in streptozotocin-diabetic rats. Diabetologia 21: 409–414
Leegwater DC, Kuper CF (1984) Evaluation of histological changes in the kidneys of the alloxan diabetic rat by means of factor analysis. Food Chem Thoxicol 22: 551–557
Michels LD, O’Donnell MP, Keane WF (1984) Glomerular hemodynamic and structural correlations in longterm experimental diabetic rats. J Lab Clin Med 103: 840–847
Morita T, Churg J (1983) Mesangiolysis. Kidney Int 24: 1–9
Risteli J, Draeger KE, Regitz G, Neubauer HP (1982) Increase in circulating basement membrane antigens in diabetic rats and effects of insulin treatment. Diabetologia 23: 266–269
Steffes MW, Mauer SM (1984) Diabetic glomerulopathy in man and experimental animal models. Int Rev Exp Pathol 26: 147–175
Steffes MW, Vernier RL, Brown DM, Basgen JM, Mauer SM (1982) Diabetic glomerulopathy in the uninephrectomized rat resists amelioration following islet transplantation. Diabetologia 23: 347–353
Volkmann P, Wehner H (1986) Renal vessel changes in diabetic KK-mice. Virchows Arch [A] (to be published)
Wehner H (1977) Morphologie der diabetischen Nephropathie. Munch Med Wochenschr 119: 489–492
Wehner H, Petri M (1983) Glomerular alterations in experimental diabetes of the rat. Pathol Res Pract 176: 145–157
Wehner H, Höhn D, Faix-Schade U, Huber H, Walzer P (1972) Glomerular changes in mice with spontaneous hereditary diabetes. Lab Invest 27: 331–340
Wehner H, Kösters W, Strauch M, Staudenmeier M (1980) Effect of islet transplantation on the glomerular changes in streptozotocin-diabetic rats. Virchows Arch (A) 88: 137–154
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Wehner, H. (1986). Effect of Experimental Diabetes Mellitus, Kidney, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96956-0_28
Download citation
DOI: https://doi.org/10.1007/978-3-642-96956-0_28
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-96958-4
Online ISBN: 978-3-642-96956-0
eBook Packages: Springer Book Archive