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The Pathophysiology of Atopic Eczema: Synopsis

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Handbook of Atopic Eczema

Abstract

While the pathomechanisms of allergic respiratory diseases such as hay fever or extrinsic bronchial asthma are rather well established, the role of allergic reactions in the pathophysiology of atopic eczema is still controversial. Two main currents can be detected in the history of the literature that try to explain the disease: specifically altered immune reactivity (i.e., allergy), on the one hand, and nonspecifically altered reactivity on the other [5, 18, 31, 36, 47, 52].

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References

  1. Atherton DJ (1981) Allergy and atopic eczema. I and II. Clin Exp Dermatol 6: 191, 317

    Article  PubMed  CAS  Google Scholar 

  2. Bieber T, Rieger A, Neuchrist C, Prinz JC, Rieber EP, Boltz-Nitulescu G, Scheiner O, Kraft D, Ring J (1989) Induction of Fc R2/CD23 on human epidermal Langerhans cells by human recombinant Interleukin 4 and y Interferon. J Exp Med 170: 309–314

    Article  PubMed  CAS  Google Scholar 

  3. Björkstén B, Kjellman NIM (1987) Perinatal factors influencing the development in allergy. Clin Rev Allergy 5: 339

    PubMed  Google Scholar 

  4. Bode U, Ring J, Neubert U (1982) Intrakutantestungen und bakteriologische Untersuchungen bei Patienten mit atopischem Ekzem. Allergologie 5: 259–261

    Google Scholar 

  5. Borelli S, Schnyder UW (1962) Neurodermitis constitutionalis sive atopica. II. Ätiologie, Pathophysiologie, Pathogenese, Therapie. In: Miescher G, Storck H (eds) Entzündliche Dermatosen I. Springer, Berlin Göttingen Heidelberg pp 254–319 (Handbuch der Haut-und Geschlechtskrankheiten) vol 1/1

    Google Scholar 

  6. Braun-Falco O, Ring J (1984) Zur Therapie des atopischen Ekzems. Hautarzt 35: 447–454

    PubMed  CAS  Google Scholar 

  7. Brostoff J, Carini C, Wraith DG, Johns P (1979) Production of IgE complexes by allergen challenge in atopic patients and the effect of sodium cromoglycate. Lancet 1: 1268–1270

    Article  PubMed  CAS  Google Scholar 

  8. Bruijnzeel-Koomen C, van Wichen L, Toonstra J, Berrens Bruijnzeel P (1986) The presence of IgE molecules on epidermal Langerhans cells from patients with atopic dermatitis. Arch Dermatol Res 278: 199–205

    Article  Google Scholar 

  9. Capron M, Jouault T, Prin L, Joseph M, Ameisen J, Butterworth A, Papin J, Kusnierz J, Capron A (1986) Functional study of a monoclonal antibody to IgE Fc receptor (FcER2) on eosinophils, platelets and macrophages. J Exp Med 164: 72–89

    Article  PubMed  CAS  Google Scholar 

  10. Coca AF, Cooke RA (1923) On the classification of the phenomena of hypersensitiveness. J Immunol 8: 163–182

    CAS  Google Scholar 

  11. Dahl MV (1983) Staphylococcus aureus and atopic dermatitis. Arch Dermatol 119: 840–846

    Article  PubMed  CAS  Google Scholar 

  12. Enders F, Przybilla B, Ring J, Burg G, Braun-Falco O (1988) Epikutantestung mit einer Standardreihe. Ergebnisse bei 12026 Patienten. Hautarzt 39: 779–786

    PubMed  CAS  Google Scholar 

  13. Hanifin J (1983) Atopic dermatitis and other endogenous eczemas. Semin Dermatol 2: 1–44

    Google Scholar 

  14. Hjorth N, Roed-Petersen J (1976) Occupational protein contact dermatitis in foodhandlers. Contact Dermatitis 2: 28–42

    Article  PubMed  CAS  Google Scholar 

  15. Hornstein OP, Bäurle G, Kienlein-Kletschka B (1985) Prospektivstudie zur Bedeutung konstitutioneller Parameter für die Ekzemgenese im Friseur-and Baugewerbe. Dermatosen 33: 43–49

    CAS  Google Scholar 

  16. Ishizaka K (1989) Regulation of immunoglobulin E biosynthesis. Adv Immunol 47: 1–44

    CAS  Google Scholar 

  17. Jakob T, Hermann KJ, Ring J (1991) Eosinophil cationic protein in atopic eczema. Arch. Dermatol. Res. 283: 5–6

    Google Scholar 

  18. Korting GW (1954) Zur Pathogenese des endogenen Ekzems. Thieme, Stuttgart

    Google Scholar 

  19. Kunz B, Vieluf D, Ring J (1988) Efficacy of oral disodium cromoglycate ( DSCG) in atopic eczema. New Engl Reg Allergy Proc 9: 411

    Google Scholar 

  20. Kunz B, Ring J, Überla K (1989) Frequency of atopic diseases and allergic sensitization in preschool children in different parts of Bavaria. Allergologie [Suppl] 12: 144

    Google Scholar 

  21. Leiferman KM, Ackerman SJ, Sampson HA, Haugen HS, Venencie PY, Gleich GJ (1985) Dermal deposition of eosinophil-granule major basic protein in atopic dermatitis. Comparison with onchocerciasis. N Engl J Med 313: 282–285

    Google Scholar 

  22. Leyden JJ, Marples RR, Kligman AM (1974) Staphylococcus aureus in the lesions of atopic dermatitis. Br J Dermatol 90: 525–530

    Article  PubMed  CAS  Google Scholar 

  23. Marchionini A (1960) Neuere Untersuchungen über die Neurodermitis constitutionalis. In: Marchionini A (ed) Fortschritte der praktischen Dermatologie und Venerologie, vol3. Springer, Berlin Göttingen Heidelberg, pp 42–62

    Google Scholar 

  24. Marghescu S (1985) Patch test reactions in atopic patients. Acta Derm Venereol (Stockh.) 114: 113–116

    CAS  Google Scholar 

  25. Marsh DG, Hsu SH, Hussam R, Meyer DA, Freidhoff LR, Bias WB (1980) Genetics of human immune response to allergens. J Allergy Clin Immunol 65: 322–330

    Article  PubMed  CAS  Google Scholar 

  26. Merrett J, Barnetson R, Burr M, MerrettT(1984)Total and specific IgG4 antibody levels in atopic eczema. Clin Exp Immunol 56: 645–662

    Google Scholar 

  27. Middleton EC, Ellis B, Reed E (eds) (1978) Allergy: principles and practice. Mosby, St Louis

    Google Scholar 

  28. Platts-Mills TAE, Mitchell EB, Rowntree S, Chapman MD, Wilkins SR (1983) The role of dust mite allergens in atopic dermatitis. Clin Exp Dermatol 233–247

    Google Scholar 

  29. Pierard GE (1987) What does “dry skin” mean? Int J Dermatol 26: 167–168

    Article  PubMed  CAS  Google Scholar 

  30. Przybilla B, Ruzicka T, Ring J (1988) Die Bedeutung von Nahrungsmittelallergien bei atopischem Ekzem. Allergologie 2: 63–67

    Google Scholar 

  31. Rajka G (1989) Essential aspects of atopic dermatitis. Springer, Berlin

    Book  Google Scholar 

  32. Reitamo S, Visa K, Kahonen K, Stubb S, Salo 0 (1986) Eczematous reactions in atopic dermatitis patients caused by epicutaneous testing with inhalant allergens. Br J Dermatol 114: 303–310

    CAS  Google Scholar 

  33. Ring J (1981) Atopic dermatitis: a disease of immunvegetative (autonomic) dysregulation. In: Ring J, Burg G (eds) New trends of allergy. Springer, Berlin Heidelberg New York, pp 237–249

    Chapter  Google Scholar 

  34. Ring J (1984) Nahrungsmittelallergie und atopisches Ekzem. Allergologie 7: 300–306

    Google Scholar 

  35. Ring J (1988) Angewandte Allergologie, 2nd edn., MMVVieweg, Munich

    Google Scholar 

  36. Ring J, Dorsch W (1985) Altered releasability of vasoactive mediator secreting cells in atopic eczema. Acta Derm Venereol (Stockh.) 114: 9–23

    CAS  Google Scholar 

  37. Ring J, Kunz B, Bieber T, Vieluf D, Przybilla B (1989) The “Atopy Patch Test” with aeroallergens in atopic eczema. J Allergy Clin Immunol 82: 195

    Google Scholar 

  38. Ruzicka T, Ring J (1987) Enhanced releasability of prostaglandin E2 and leukotrienes B4 and C4 from leukocytes of patients with atopic eczema. Acta Derm Venereol (Stockh.) 67: 469–475

    CAS  Google Scholar 

  39. Ruzicka T, Simmet T, Peskar BA, Braun-Falco 0 (1984) Leukotrienes in skin of atopic dermatitis. Lancet 1: 222–223

    CAS  Google Scholar 

  40. Sampson HA, MacCaskill CC (1985) Food hypersensitivity and atopic dermatitis: evaluation of 113 patients. J Pediatr 107: 669–675

    Article  PubMed  CAS  Google Scholar 

  41. Schnyder UW (1960) Neurodermitis-Asthma-Rhinitis. Eine genetisch-allergologische Studie. Int Arch Allergy Appl Immunol [Suppl] 17: 1–106

    Google Scholar 

  42. Schöpf E (1974) Störung zellvermittelter Immunreaktionen bei Neurodermitis atopica. Verminderte Spontanrosettenbildung von T-Lymphozyten. Dermatologica 149: 210

    Article  PubMed  Google Scholar 

  43. Schopfer K, Baerlocher K, Price P, Krech U, Quie PG, Douglas SD (1979) Staphylococcal IgE antibodies, hyperimmunoglobulinemia E and Staphylococcus aureus infections. N Engl J Med 300: 835–838

    CAS  Google Scholar 

  44. Schultz-Larsen F, Holm NV, Hennigsen K (1986) Atopic dermatitis. A genetic-epidemiologic study in a population-based twin sample. J Am Acad Dermatol 15: 487–494

    Google Scholar 

  45. Spiegelberg HL, Boltz-Nitulescu G, Plummer JM, Melewiez FM (1983) Characterization of the IgE Fe receptors on monocytes and macrophages. Fed Proc 42: 124–128

    PubMed  CAS  Google Scholar 

  46. Stingl G, Gazze L, Czarnecki N, Wolff K (1981) T-cell abnormalities in atopic dermatitis patients. Imbalance in T-cell subpopulation and impaired generation of con-A-induced suppressor cells. J Invest Dermatol 76: 468–473

    Google Scholar 

  47. Szentivanyi A (1968) The beta adrenergic theory of the atopic abnormality in asthma. J Allergy 42: 203

    Article  Google Scholar 

  48. Vieluf D, Przybilla B,Traenckner I, Ring J (1990) Oral provocation with food additives in atopic eczema. J Allergy Clin Immunol 85: 206

    Google Scholar 

  49. Waersted A, Hjorth N (1985) Pityrosporum orbiculare: a pathogenetic factor in atopic dermatitis of the face, scalp and neck. Acta Derm Venereol [Suppl] (Stockh.) 114: 146–148

    CAS  Google Scholar 

  50. Wright S, Burton JL (1982) Oral evening-primrose-seed-oil improves atopic eczema. Lancet 2: 1120–1122

    Article  PubMed  CAS  Google Scholar 

  51. Wüthrich B (1975) Zur Immunpathologie der Neurodermatitis constitutionalis. Huber, Bern

    Google Scholar 

  52. Wüthrich B (1983) Neurodermitis atopica sive constitutionalis. Ein pathogenetisches Modell aus der Sicht des Allergologen. Aktuel Dermatol 9: 1–7

    Google Scholar 

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Ring, J., Ruzicka, T., Przybilla, B. (1991). The Pathophysiology of Atopic Eczema: Synopsis. In: Ruzicka, T., Ring, J., Przybilla, B. (eds) Handbook of Atopic Eczema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02671-7_35

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  • DOI: https://doi.org/10.1007/978-3-662-02671-7_35

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