Abstract
During the past decade relevant research efforts have been directed to identify some of the key steps within the multitude of biochemical and electrophysiological events which constitute the cellular mechanisms involved in learning and memory. A substantial advancement in this field has been obtained with the discovery of the electrophysiological phenomenon of long-term potentiation (Bliss and L0mo, 1973) which provided the possibility to reproduce, either in vivo or in vitro, an enduring enhancement of electrophysiological responses in several pathways of the hippocampus, a brain structure which is involved in learning. Since then, long-term potentiation (LTP) has been proposed as a model to study cellular mechanisms of learning (Teyler and DiScenna, 1987), and has provided the possibility of combining several approaches to the study of biochemical and electrophysiological events involved in information processing in the hippocampus. The more representative among them, ranging from release of glutamate to mobilization of arachidonic acid or activation of protein kinases and phosphorylation of protein substrates, have been outlined in the preceding contributions by Dr. Lynch and by Dr. Routtenberg.
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© 1993 Springer-Verlag Berlin Heidelberg
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Corradetti, R., Nunzi, M.G., Gispen, W.H., Gianotti, C. (1993). B-50 Phosphorylation in Response to Different Patterns of Electrical Stimulation in Rat Hippocampal Slices. In: Massarelli, R., Horrocks, L.A., Kanfer, J.N., Löffelholz, K. (eds) Phospholipids and Signal Transmission. Nato ASI Series, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02922-0_14
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DOI: https://doi.org/10.1007/978-3-662-02922-0_14
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