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Regulation of Phosphatidylserine Synthesis during T Cell Activation

  • Conference paper
Phospholipids and Signal Transmission

Part of the book series: Nato ASI Series ((volume 70))

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Abstract

The importance of phospholipids in biological systems has become increasingly recognized in recent years. In T cells as in other cells, a majority of investigators have focused their research on the role of the phosphoinositide (Ptdlns) cycle as a system that generates the lipidic second messengers. Our studies on T lymphocytes have shown that other phospholipids and particularly phosphatidylserine (PtdSer) could play an essential role in T cell activation monitored by the measurement of interleukin-2 synthesis. The present paper takes stock of our current knowledge on the regulation of PtdSer synthesis during T cell activation and on its possible role in the regulation of interleukin-2 synthesis in Jurkat cells, a leukemic T cell line widely used as a model for the studies on lymphocyte activation.

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Author information

Authors and Affiliations

  1. Immunologie Cellulaire et Moleculaire, INSERM U210, Faculté de Médecine, 06034, Nice cédex, France

    Claude Aussel

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  1. Claude Aussel
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Editor information

Editors and Affiliations

  1. CNRS, Centre de Neurochimie, Strasbourg, France

    Raphaël Massarelli (Director of Research) (Director of Research)

  2. Department of Medical Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA

    Lloyd A. Horrocks (Professor Emeritus) (Professor Emeritus)

  3. Department of Biochemistry and Molecular Biology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Julian N. Kanfer (Professor) (Professor)

  4. Department of Pharmacology, University of Mainz, Mainz, Germany

    Konrad Löffelholz (Professor) (Professor)

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© 1993 Springer-Verlag Berlin Heidelberg

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Aussel, C. (1993). Regulation of Phosphatidylserine Synthesis during T Cell Activation. In: Massarelli, R., Horrocks, L.A., Kanfer, J.N., Löffelholz, K. (eds) Phospholipids and Signal Transmission. Nato ASI Series, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02922-0_17

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  • DOI: https://doi.org/10.1007/978-3-662-02922-0_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-02924-4

  • Online ISBN: 978-3-662-02922-0

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