Abstract
Since the beginning of pharmacological use of glucocorticoids it has been clear that they have serious adverse effects in bone. Chronic administration of glucocorticoids causes a loss of bone mass and pathological fractures, especially in the skeletal areas that are rich in trabecular bone. In addition to osteoporosis, large doses of glucocorticoids could lead to aseptic osteonecrosis affecting mainly proximal femur.
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Väänänen, K.H., Härkönen, P.L. (2002). Bone Effects of Glucocorticoid Therapy. In: Cato, A.C.B., Schäcke, H., Asadullah, K. (eds) Recent Advances in Glucocorticoid Receptor Action. Ernst Schering Research Foundation Workshop, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04660-9_4
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DOI: https://doi.org/10.1007/978-3-662-04660-9_4
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