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Identification and Characterization of Viral Antagonists of Type I Interferon in Negative-Strand RNA Viruses

  • Chapter
Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 283))

Abstract

Interferons are cytokines secreted in response to viral infections with potent antiviral activity, and they represent a critical component of the innate immune response against viruses. It has now become apparent that many viruses have evolved different mechanisms to counteract the interferon response, allowing their efficient replication and propagation in their hosts. This review discusses how the development of reverse genetics techniques and the increase in our knowledge of the interferon response have led to the discovery of interferon-antagonistic functions of different genes of viruses belonging to the negative-strand RNA virus group. In many cases, these viral genes encode accessory proteins that are not required for viral infectivity but are critical for optimal replication and for virulence in the host.

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  1. Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY, 10029, USA

    A. García-Sastre

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  1. School of Veterinary Medicine Department of Pathobiological Sciences, University of Wisconsin-Madison, 2015 Linden Drive West, 535706, Madison, Wisconsin, USA

    Yoshihiro Kawaoka DVM, PhD

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García-Sastre, A. (2004). Identification and Characterization of Viral Antagonists of Type I Interferon in Negative-Strand RNA Viruses. In: Kawaoka, Y. (eds) Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics. Current Topics in Microbiology and Immunology, vol 283. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06099-5_7

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  • DOI: https://doi.org/10.1007/978-3-662-06099-5_7

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