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Autoimmunität

  • Chapter
Immunsystem und Infektiologie

Part of the book series: Handbuch der Molekularen Medizin ((HDBMOLEK,volume 4))

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Zusammenfassung

Autoimmunität ist definiert als eine spezifische, adaptive humorale und/oder zelluläre Immunantwort gegen körpereigene Antigene [Selbst(Auto)-antigene]. Autoimmunkrankheiten sind klinisch definiert als chronische, nichtinfektiöse Entzündungszustände, die entweder zur lokalisierten Organdestruktion (z.B. Typ-I-Diabetes, Hashimoto-Thyreoiditis) oder zu systemischen Krankheitsbildern des rheumatischen Formenkreises führen [z.B. systemischer Lupus erythematosus (SLE), Rheumatoide Arthritis] (Peter u. Pichler 1996). Serologisch sind Autoimmunkrankheiten charakterisiert durch den Nachweis hochtitriger Autoantikörper des IgG- und IgA-Isotyps gegen definierte Autoantigene. Immungenetisch finden sich regelmäßig Assoziationen mit bestimmten MHC-Haplotypen (Schwarz 1996).

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  1. Hans Hartmut Peter
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  2. Inga Melchers
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  3. Hermann Eibel
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Peter, H.H., Melchers, I., Eibel, H. (1999). Autoimmunität. In: Ganten, D., Ruckpaul, K. (eds) Immunsystem und Infektiologie. Handbuch der Molekularen Medizin, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07865-5_7

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