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Bone Morphogenetic Proteins: Role, Modes of Action and Potential Significance in Osteoporosis

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Novel Approaches to Treatment of Osteoporosis

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 25))

Abstract

The osteoblast differentiation pathway is characterized by the commitment of osteoprogenitor cells from mesenchymal stem cells, the progressive differentiation of pre-osteoblasts associated with the expression of genes of the osteoblast phenotype, and the synthesis, deposition and mineralization of bone matrix by post-mitotic mature osteoblasts. This differentiation process is controlled by a variety of local factors acting on skeletal cell proliferation and differentiation to initiate and promote bone matrix formation during skeletal development, formation and repair (Aubin et al. 1993; Baylink et al. 1993; Mundy 1993; Marie and DeVernejoul 1993; Marie et al. 1994).

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  1. P. J. Marie
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Editors and Affiliations

  1. Human Metabolism and Clinical Biochemistry, Sheffield University Medical School, Beech Hill Road, S 10 2RX, Sheffield, UK

    R. Graham G. Russell

  2. Department of Biology, University of York, PO Box 373, YO1 5YW, York, UK

    Timothy M. Skerry

  3. FC/HT Research, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    Uwe Kollenkirchen

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Marie, P.J. (1998). Bone Morphogenetic Proteins: Role, Modes of Action and Potential Significance in Osteoporosis. In: Russell, R.G.G., Skerry, T.M., Kollenkirchen, U. (eds) Novel Approaches to Treatment of Osteoporosis. Ernst Schering Research Foundation Workshop, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09007-7_11

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