Abstract
Mast cells are characteristic elements of the connective tissues and appear to serve as cellular sites for storage and release of both heparin and histamine in the tissues. These cells respond to various kinds of injurious stimuli by shedding their histamine- and heparin-containing granules into the ground substance where their biologically-active substances may influence subsequent tissue responses. A great deal of interest has been focussed on the possibility that these cells may play an important role in the development of allergic and other types of inflammatory lesions of the connective tissues. An important aspect of research in this area has been concerned with the release of histamine from mast cells in response to administration of histamine releaser drugs (Riley, 1959). It is of interest that amongst the various speculations on the mechanisms involved in histamine release is the suggestion that this cellular response to cationic histamine releasers may be effected through an ion exchange mechanism in the mast cell granules in which histamine is competitively displaced by the releaser agent and heparin serves as the cation exchanger (Green, 1962; Küttner, 1961). The following discussion will be concerned with the role of heparin in the interaction of mast cells and histamine releaser drugs and, for the sake of brevity, will not attempt to consider the importance of histamine in this reaction.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Burton, A. L.: Observations préliminaires sur le sort des mast cells du fluide péritonéal de rat en cultures de tissus. Rev. canad. Biol. 18, 103 (1959).
Darlow, G.: Reaction between histamine liberators and phosphates. J. Physiol. (Lond.) 131, 13P (1956).
Dougherty, T. F., and G. Schneebeli: Microcinematographic demonstration of mast cell disintegration in living isolated loose connective tissue of mice (motion picture). Fed. Proc. 17, 37 (1958).
Eder, M., A. Schauer: Fermenthistochemische und experimentelle Untersuchungen an Gewebsmastzellen. Beitr. path. Anat. 124, 251 (1961).
Green, J. P.: Binding of some biogenic amines in tissues. Advanc. Pharmacol. 1, 349 (1962).
Hagen, P.: Biosynthesis and storage of histamine, heparin and 5-hydroxytryptamine in the mast cell. Canad. J. Biochem. 39, 639 (1961).
Harris, A. F., A. Satter and S. K. Weintraub: Interaction of compound 48/80 and stilbamidine with strandin. Proc. Soc. exp. Biol. (N. Y.) 107, 35 (1961).
Higgtnbotham, R. D.: Studies on the functional interrelationship of fibroblasts and ground substance mucopolysaccharides. Ann. N. Y. Acad. Sci. 73, 186
Higgtnbotham, R. D.: (1958a). Mast cells, heparin and toxic agents. Fed. Proc. 17, 516
Higgtnbotham, R. D.: (1958b). On the participation of micellophagosis in the resistance of tissues to injurious agents. Int. Arch. Allergy 15, 195 (1959a).
Higgtnbotham, R. D.: Effect of compound 48/80 on toxicity of histamine and of serotonin in mice. Proc. Soc. exp. Biol. (N. Y.) 102, 4 (1959b).
Higgtnbotham, R. D.: Effect of heparin on neomycin. Tex. Rep. Biol. Med. 18, 408 (1960).
Higgtnbotham, R. D.: Sulfated polysaccharides and resistance to Russell’s viper venom. Proc. Soc. exp. Biol. (N. Y.) 110, 135 (1962).
Higginbotham, R. D. and T. F. Dougherty: Mechanism of heparin protection against a histamine releaser (48/80). Proc. Soc. exp. Biol. (N. Y.) 92, 493 (1956).
Higginbotham, R. D. and T. F. Dougherty: Potentiation of polymyxin B toxicity by Acth. Proc. Soc. exp. Biol. (N. Y.) 96, 466 (1957).
Higginbotham, R. D. and T. F. Dougherty, and W. S. S. Jee: The fate of shed mast cell granules. Proc. Soc. exp. Biol. (N. Y.) 92, 256 (1956).
Jaques, L. B.: Reaction of heparin with proteins and complex bases. Biochem. J. 37, 189 (1943).
Kitchener, J. A.: Properties and behavior: swelling and equilibria. In: Ion Exchangers in Organic and Biochemistry. New York: Interscience Publishers 1957.
KiiTtner, K.: Ionenaustausch biologisch wichtiger Amine an synthetischen und natürlichen Austauschern als Modell für die pharmakologische Histaminliberation. Inaugural-Dissertation, University of Bern, Switzerland (1961).
Mota, I., W. T. Beraldo, and L. C. U. Junqueira: Protamine-like property of compound 48/80 and stilbamidine and their action on mast cells. Proc. Soc. exp. Biol. (N. Y.) 83, 455 (1953).
Padawer, J.: Studies on mammalian mast cells. Trans. N. Y. Acad. Sei. 19, 690 (1957).
Papacostas, C. A., E. R. Loew, and G. B. West: Studies on the toxicology of a histamine liberator, compound 48/80. Arch. in Pharmacodyn. 120, 353 (1959).
Riley, J. F.: The effects of histamine liberators on the mast cells of the rat. J. Path. Bact. 65, 471 (1953).
Riley, J. F.: The Mast Cells. Edinburgh, Scotland: E. & S. Livingstone, Ltd. 1959.
Rocha E Silva, M.: Histamine. Its Role in Anaphylaxis and Allergy. Springfield, Illinois Charles C. Thomas 1955.
Smith, D. E.: Dynamics of release of histamine from tissue mast cells. Science 128, 207 (1958).
Smith, D. E., and Y. Lewis: Phagocytosis of granules from disrupted mast cells. Anat. Rec. 132, 93 (1958).
Walton, K. W.: Chemistry and mode of action of heparin and related compounds. Brit. med. Bull. 11, 62 (1955).
Editor information
Rights and permissions
Copyright information
© 1966 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Higginbotham, R.D. (1966). Interaction of Mast Cells with Cationic Histamine Releasers. In: Rocha e Silva, M. (eds) Histamine and Anti-Histaminics. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 18 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12016-3_22
Download citation
DOI: https://doi.org/10.1007/978-3-662-12016-3_22
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-12018-7
Online ISBN: 978-3-662-12016-3
eBook Packages: Springer Book Archive