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Sarcomatoid Carcinomas of the Breast: An Immunocytochemical Study of 14 Cases

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Progress in Surgical Pathology

Abstract

Sarcomatoid carcinomas are biphasic tumors composed of both carcinomatous and sarcomatous elements.1–3 They constitute an uncommon but morphologically well documented entity described in numerous sites. Eight cases of spindle-cell epidermoid carcinoma occurring in the skin of the face and shoulder were described by Martin and Stewart.4 Subsequently, similar cases, carrying various names, have been documented, mostly in the upper aerodigestive tract5,6 such as the mouth,7–10 paranasal sinuses,11 larynx,5,9,12–16pharynx,7,17 and esophagus.7,18–22 Other locations for sarcomatoid carcinomas include salivary glands,23,24 stomach,25 small intestine,26 large intestine,27 pancreas28 and anal canal.29 Other cases have been described in the brain,30 thyroid,31,32 and urogenital tract.33–40 Several cases have also been described in the lungs41–43 and skin.44,45

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References

  1. Leventon GS, Evans HL: Sarcomatoid squamous cell carcinoma of the mucous membranes of the head and neck. Cancer 48:994–1003, 1981

    Article  PubMed  CAS  Google Scholar 

  2. Meis JM, Ordonez NG, Gallager HS: Sarcomatoid carcinoma of the breast: An immunohistochemical study of six cases. Virch Arch A 410:415–421, 1987

    Article  CAS  Google Scholar 

  3. Weidner N: Sarcomatoid carcinoma of the upper aerodigestive tract. Seminars in Diagnostic Pathology 4:157–168, 1987

    PubMed  CAS  Google Scholar 

  4. Martin HE, Stewart FW: Spindle-cell epidermoid carcinoma. Am J Cancer 24:273–298, 1935

    Article  Google Scholar 

  5. Zarbo RJ, Crissman JD, Venkat H, et al: Spindle-cell carcinoma of the upper aerodigestive tract mucosa. Am J Surg Pathol 10:741–753, 1986

    Article  PubMed  CAS  Google Scholar 

  6. Ellis GL, Langloss JM, Heffner DK, et al: Spindle-cell carcinoma of the aerodigestive tract. Am J Surg Pathol 11:335–342, 1987

    Article  PubMed  CAS  Google Scholar 

  7. Lane N: Pseudosarcoma (polypoid sarcoma-like masses) associated with squamous cell carcinoma of the mouth, fauces and larynx. Report of ten cases. Cancer 10:19–41, 1957

    CAS  Google Scholar 

  8. Sherwin RB, Strong MS, Vaughn CW: Polypoid and junctional squamous cell carcinoma of the tongue and larynx with spindle-cell carcinoma (“pseudosarcoma”). Cancer 16:51–60, 1963

    Article  PubMed  CAS  Google Scholar 

  9. Ellis GL, Corio RL: Spindle-cell carcinoma of the oral cavity: A clinicopathologic assessment of fifty-nine cases. Oral Surg 50:523–534, 1980

    Article  PubMed  CAS  Google Scholar 

  10. Anonsen C, Dobie RA, Hoekema D, et al: Carcinosarcoma of the floor of the mouth. J Otolaryngol 14:215–220, 1985

    PubMed  CAS  Google Scholar 

  11. Piscioli F, Aldovini D, Bondi A, et al: Squamous cell carcinoma with sarcoma-like stroma of the nose and paranasal sinuses: Report of two cases. Histopa-thology 8:633–639, 1984

    Article  CAS  Google Scholar 

  12. Minckler DS, Meligro CH, Norris HT: Carcinosarcoma of the larynx: Case report with metastases of epidermoid and sarcomatous elements. Cancer 26:195–200, 1970

    Article  PubMed  CAS  Google Scholar 

  13. Randall G, Alonso WA, Ogura JH: Spindle-cell carcinoma (pseudosarcoma) of the larynx. Arch Otolaryngol 101:63–66, 1975

    Article  PubMed  CAS  Google Scholar 

  14. Lasser KH, Naeim F, Higgins J, et al: “Pseudosarcoma” of the larynx. Am J Surg Pathol 3:397–404, 1979

    Article  PubMed  CAS  Google Scholar 

  15. Lambert PR, Ward PH, Berci G: Pseudosarcoma of the larynx: A comprehensive analysis. Arch Otolaryngol 106:700–708, 1980

    Article  PubMed  CAS  Google Scholar 

  16. Katholm M, Krongdall A, Hainau B, et al: Spindle-cell carcinoma of the larynx. Acta Otolaryngol 98:163–166, 1984

    Article  PubMed  CAS  Google Scholar 

  17. Batsakis JG, Rice DH, Howard DR: The pathology of head and neck tumors: Spindle-cell lesions (sarcomatoid carcinomas, nodular fasciitis, and fibrosarcoma) of the aerodigestive tracts. Head Neck Surg 4:499–513, 1982

    Article  PubMed  CAS  Google Scholar 

  18. De Marco AR, Leon W, Coleman WO, et al: Pseudosarcoma of the esophagus. J Thoracic Cardiovascular Surgery 49:188–193, 1965

    Google Scholar 

  19. Scarpa FJ: Polypoid squamous carcinoma of the esophagus. Cancer 19:861–866, 1966

    Article  PubMed  CAS  Google Scholar 

  20. Fraser GM, Kinley LE: Pseudosarcoma with carcinoma of the esophagus. Arch Pathol 85:325–330, 1968

    PubMed  CAS  Google Scholar 

  21. Osamura RY, Shimamura K, Hata J, et al: Polypoid carcinoma of the esophagus. A unifying term for “carcinosarcoma” and “pseudosarcoma”. Am J Surg Pathol 2:201–208, 1978

    Article  PubMed  CAS  Google Scholar 

  22. Takubo K, Tsuchiya S, Nakagawa H, et al: Pseudosarcoma of the esophagus. Hum Pathol 13:503–505, 1982

    Article  PubMed  CAS  Google Scholar 

  23. Eusebi V, Martin SA, Govoni E, et al: Giant cell tumor of major salivary glands. Am J Clin Pathol 81:118–127, 1984

    Google Scholar 

  24. Auclair PL, Langloss JM, Weiss SW, et al: Sarcomas and sarcomatoid neoplasms of the major salivary gland regions. Cancer 58:1305–1315, 1986

    Article  PubMed  CAS  Google Scholar 

  25. Bansal M, Kaneko M, Gordon RE: Carcinosarcoma and separate carcinoid tumor of the stomach. Cancer 50:1876–1881, 1982

    Article  PubMed  CAS  Google Scholar 

  26. Radi MF, Gray GF, Scott WH: Carcinosarcoma of ileum in regional enteritis. Hum Pathol 15:385–387, 1984

    Article  PubMed  CAS  Google Scholar 

  27. Weidner N, Zekan P: Carcinosarcoma of the colon. Report of a unique case with light and immunohistochemical studies. Cancer 58:1126–1130, 1986

    Article  PubMed  CAS  Google Scholar 

  28. Leman BI, Walker PD: Sarcomatoid carcinoma of the pancreas. Am J Clin Pathol 76:351, 1981

    Google Scholar 

  29. Kuwano H, Iwashita A, Enjoji M: Pseudosarcoma-tous carcinoma of the anal canal. Dis Colon Rectum 26:123–128, 1983

    Article  PubMed  CAS  Google Scholar 

  30. Giangaspero F, Manetto V, Ferracini R, et al: Squamous cell carcinoma of the brain with sarcomalike stroma. Virch Arch A 402:459–467, 1984

    Article  CAS  Google Scholar 

  31. Carcangiu ML, Steeper T, Zampi G, et al: Anaplastic thyroid carcinoma. Am J Clin Pathol 83:135–158, 1985

    PubMed  CAS  Google Scholar 

  32. Mills SE, Stallings RG, Austin MB: Angiomatoid carcinoma of the thyroid gland. Am J Clin Pathol 86:674–678, 1986

    PubMed  CAS  Google Scholar 

  33. Wick MR, Perrone TL, Burke BA: Sarcomatoid transitional cell carcinomas of the renal pelvis. An ultrastructural and immunohistochemical study. Arch Pathol Lab Med 109:55–58, 1985

    PubMed  CAS  Google Scholar 

  34. Macke RA, Hussain MB, Imray TJ, et al: Osteogenic and sarcomatoid differentiation of a renal cell carcinoma. Cancer 56:2452–2457, 1985

    Article  PubMed  CAS  Google Scholar 

  35. Shu-Chao P: Bony and cartilagineous tumors of the urinary bladder. J Path Bact 76:357–377, 1958

    Article  Google Scholar 

  36. Yamashina M, Kobara TY: Primary squamous cell carcinoma with its spindle cell variant in the endometrium. Cancer 57:340–345, 1986

    Article  PubMed  CAS  Google Scholar 

  37. Czernobilsky B, Rotenstreich L, Lancet M: Ovarian dermoid with squamous carcinoma-pseudosarcoma. Arch Pathol 93:141–144, 1972

    PubMed  CAS  Google Scholar 

  38. Ro JY, Ayala AG, Sella A, et al: Sarcomatoid renal cell carcinoma: Clinicopathologic. Cancer 59:516–526, 1987

    Article  PubMed  CAS  Google Scholar 

  39. Susil BJ, Sumithran E: Sarcomatous change in granulosa cell tumor. Hum Pathol 18:392–399, 1987

    Article  Google Scholar 

  40. Steeper TA, Piscioli F, Rosai J: Squamous cell carcinoma with sarcoma-like stroma of the female genital tract. Cancer 52:890–898, 1983

    Article  PubMed  CAS  Google Scholar 

  41. Zimmerman KG, Sobonya KE, Payne CM: Histo-chemical and ultrastructural features of an unusual pulmonary carcinosarcoma. Hum Pathol 12:1046–1051, 1982

    Article  Google Scholar 

  42. Huszar M, Herczeg E, Lieberman Y, et al: Distinctive immunofluorescent labeling of epithelial and mesenchymal elements of carcinosarcoma with antibodies specific for different intermediate filaments. Hum Pathol 15:532–538, 1984

    Article  PubMed  CAS  Google Scholar 

  43. Addis BJ, Corrin B: Pulmonary blastoma, carcinosarcoma, and spindle-cell carcinoma: An immuno-histochemical study of Keratin intermediate filaments. J Pathol 142:291–301, 1985

    Article  Google Scholar 

  44. Evans HL, Smith JL: Spindle cell squamous carcinomas and sarcoma-like tumors of the skin. Cancer 45:2687–2697, 1980

    Article  PubMed  CAS  Google Scholar 

  45. Eusebi V, Ceccarelli C, Piscioli F, et al: Spindle cell tumours of the skin of debatable origin. An immunocytochemical study. J Pathol 144:189–199, 1984

    Article  PubMed  CAS  Google Scholar 

  46. Kaufman MW, Marti JR, Gallager S, et al: Carcinoma of the breast with pseudosarcomatous metaplasia. Cancer 53:1908–1917, 1984

    Article  PubMed  CAS  Google Scholar 

  47. Govan ADT: Two cases of mixed malignant tumour of the breast. J Path Bact 57:397–404, 1945

    Article  PubMed  CAS  Google Scholar 

  48. Llombart-Bosch A, Peydro A: Malignant mixed osteogenic tumours of the breast. Virch Arch A 366:1–14, 1925

    Google Scholar 

  49. Hager J, Lederer B: Maligner Mischtumor der Brus-tarüse. Zbl All Pathol u Anat Bd 121:522–525, 1977

    CAS  Google Scholar 

  50. Harris M, Persaud V: Carcinosarcoma of the breast. J Pathol 112:99–105, 1974

    Article  PubMed  CAS  Google Scholar 

  51. Azzopardi JG: Problems in breast pathology, in Bennington JL (ed). Major Problems in Pathology, Vol. 11; London, W.B. Saunders Co., 1979

    Google Scholar 

  52. Jones EL: Primary squamous-cell carcinoma of breast with pseudosarcomatous stroma. J Pathol 97:383–387, 1969

    Article  PubMed  CAS  Google Scholar 

  53. Gersell DJ, Katzenstein AA: Spindle-cell carcinoma of the breast. Hum Pathol 12:550–561, 1981

    Article  PubMed  CAS  Google Scholar 

  54. Bauer TW, Rostock RA, Eggleston JC, et al: Spindle cell carcinoma of the breast: Four cases and review of the literature. Hum Pathol 15:147–152, 1984

    Article  PubMed  CAS  Google Scholar 

  55. Tudhope GR: A complex malignant mammary tumour. J Path Bact 48:499–506, 1939

    Article  Google Scholar 

  56. Kahn LB, Uys CJ, Dales J, et al: Carcinoma of the breast with metaplasia to chondrosarcoma: A light and electron microscopic study. Histopathol-ogy 2:93–106, 1978

    Article  CAS  Google Scholar 

  57. Hanada M, Nakano K, Ii Y, et al: Carcinosarcoma of the esophagus with osseous and cartilagineous production. Acta Pathol Jpn 34:669–678, 1984

    PubMed  CAS  Google Scholar 

  58. Macke RA, Hussain MB, Imray TJ, et al: Osteogenic and sarcomatoid differentiation of a renal carcinoma. Cancer 56:2452–2457, 1985

    Article  PubMed  CAS  Google Scholar 

  59. Pang LSC: Bony and cartilagineous tumours of the urinary bladder. J Pathol Bacteriol 76:357–364, 1958

    Article  PubMed  CAS  Google Scholar 

  60. Evans RW: Histological appearances of tumours. Edinburgh, London, Livingstone Ltd., 1968

    Google Scholar 

  61. Hsu S-M, Raine L, Fanger H: A comparative study of the peroxidase-antiperoxidase method and an avi-din-biotin-complex method for studying polypeptide hormones with radioimmunoassay antibodies. Am J Clin Pathol 75:734–738, 1981

    PubMed  CAS  Google Scholar 

  62. Hsu S-M, Raine L, Fanger H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577–580, 1981

    Article  PubMed  CAS  Google Scholar 

  63. Bloom HJC, Richardson WW: Histological grading and prognosis in breast cancer: A study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer 11:359–377, 1957

    Article  PubMed  CAS  Google Scholar 

  64. Eusebi V, Millis RR, Cattani MG, et al: Apocrine carcinoma of breast: A morphologic and immunocytochemical study. Am J Pathol 123:532–541, 1986

    PubMed  CAS  Google Scholar 

  65. Salm R, Evans DJ: Myxoid leiomyosarcoma. Histo-pathology 9:159–169, 1985

    CAS  Google Scholar 

  66. Eusebi V, Lamovec J, Cattani MG, et al: Acantho-lytic variant of squamous-cell carcinoma of the breast. Am J Surg Pathol 10:855–861, 1986

    Article  PubMed  CAS  Google Scholar 

  67. Rosai J, Sumner HW, Kostianovsky M, et al: Angiosarcoma of the skin. Hum Pathol 7:83–109, 1976

    Article  PubMed  CAS  Google Scholar 

  68. Cameron HM, Hamperl H, Warambo W: Leiomyosarcoma of the breast originating from myothelium (myoepithelium). J Pathol 114:89–92, 1974

    Article  PubMed  CAS  Google Scholar 

  69. Bird CC: A breast sarcoma containing rhabdomyo-sarcomatous and other metaplastic elements. J Pathol 101:286–289, 1970

    Article  PubMed  CAS  Google Scholar 

  70. Miettinen M, Lehto VP, Virtanen I: Keratin in the epithelial-like cells of classical biphasic synovial sarcoma. Virch Arch B 40:157–162, 1982

    Article  CAS  Google Scholar 

  71. Chase DR, Weiss SW, Enzinger FM, et al: Keratin in epithelioid sarcoma. Am J Surg Pathol 8:435–441, 1984

    Article  PubMed  CAS  Google Scholar 

  72. Delsol G, Gatter KC, Stein H, et al: Human lymphoid cells may express epithelial membrane antigen. Implications for the diagnosis of human neoplasms. Lancet 2:1124–1129, 1984

    Article  PubMed  CAS  Google Scholar 

  73. Lazarides E: Intermediate filaments as mechanical integrators of cellular space. Nature 283:249–256, 1980

    Article  PubMed  CAS  Google Scholar 

  74. Bussolati G, Alfani G, Weber K, et al: Immunocytochemical detection of actin on fixed and embedded tissues: Its potential use in routine pathology. J Histochem Cytochem 28:169–173, 1980

    Article  PubMed  CAS  Google Scholar 

  75. Pitts WC, Rojas V, Rouse RV, et al: An immunohis-tochemical study of metaplastic carcinomas and sarcomas of the breast. Lab Invest 56:61A, 1987

    Google Scholar 

  76. Nakazato Y, Ishizeki J, Takahashi K, et al: Localization of S-100 protein and glial fibrillary acidic protein-related antigen in pleomorphic adenoma of the salivary glands. Lab Invest 46:621–626, 1982

    PubMed  CAS  Google Scholar 

  77. Leader M, Collis M, Patel J, et al: Desmin: Its value as a marker of muscle derived tumors using a commercial antibody. Virch Arch A 411:345–349, 1987

    Article  CAS  Google Scholar 

  78. Wargotz ES, Weiss SW, Norris HJ: Myofibroblas-toma of the breast. Sixteen cases of a distinctive benign mesenchymal tumor. Am J Surg Pathol 11:493–502, 1987

    Article  PubMed  CAS  Google Scholar 

  79. Wargotz ES, Norris HJ, Austin RM, et al: Fibromatosis of the breast. A clinical and pathological study of 28 cases. Am J Surg Pathol 11:38–45, 1987

    Article  PubMed  CAS  Google Scholar 

  80. Bogomeletz WV, Boulenger E, Simatos A: Infiltrating fibromatosis of the breast. J Clin Pathol 34:30–34, 1981

    Article  Google Scholar 

  81. Kaplan L, Walts AE: Benign chondrolipomatous tumor of the human female breast. Arch Pathol Lab Med 101:149–151, 1977

    PubMed  CAS  Google Scholar 

  82. Eusebi V, Cunsolo A, Fedeli F, et al: Benign smooth muscle cell metaplasia in breast. Tumori 66:643–653, 1980

    PubMed  CAS  Google Scholar 

  83. Barnes L, Pietruszka M: Rhabdomyosarcoma arising within a cystosarcoma phyllodes. Case report and review of the literature. Am J Surg Pathol 2:423–428, 1978

    Article  PubMed  CAS  Google Scholar 

  84. Enzinger FM, Weiss SW: Soft Tissue Tumors. St Louis, C.V. Mosby Co., 1983

    Google Scholar 

  85. De Jong ASH, Van Kessel-Van Vark M, Albus-Lutter ChE: Pleomorphic rhabdomyosarcoma in adults: Immunohistochemistry as a tool for its diagnosis. Hum Pathol 18:298–303, 1987

    Article  PubMed  Google Scholar 

  86. Hamperl H: The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors. Current Topics in Pathology, vol. 53. Berlin, Springer-Verlag 1970, 161

    Google Scholar 

  87. Franke WW, Schmid E, Schiller DL, et al: Differentiation-related patterns of expression of proteins of intermediate-size filaments in tissues and cultured cells. Cold Spring Harbor Symp Quant Biol 46:431–454, 1982

    Article  PubMed  Google Scholar 

  88. Lehtonen E, Lehto VP, Paasivuo R, et al: Parietal and visceral endoderm differ in their expression of intermediate filaments. EMBO J 2:1023–1028, 1983

    PubMed  CAS  Google Scholar 

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Authors
  1. Vincenzo Eusebi
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  2. Maria G. Cattani
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  3. Claudio Ceccarelli
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  4. Janez Lamovec
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Editors and Affiliations

  1. University of New Mexico, USA

    M. Cecilia Fenoglio-Preiser M.D. (Professor of Pathology, Director of Laboratory Services) (Professor of Pathology, Director of Laboratory Services)

  2. Albuquerque Veterans Administration Medical Center, Albuquerque, New Mexico, USA

    M. Cecilia Fenoglio-Preiser M.D. (Professor of Pathology, Director of Laboratory Services) (Professor of Pathology, Director of Laboratory Services)

  3. Columbia University College of Physicians and Surgeons, and Department of Pathology, Memorial Hospital, Morristown, New Jersey, USA

    Marianne Wolff M.D. (Professor of Clinical Surgical Pathology) (Professor of Clinical Surgical Pathology)

  4. National Cancer Institute, Milan, Italy

    Franco Rilke M.D. (Deputy Director, Director, Professor) (Deputy Director, Director, Professor)

  5. Division of Pathology, Italy

    Franco Rilke M.D. (Deputy Director, Director, Professor) (Deputy Director, Director, Professor)

  6. Postgraduate School of Anatomic Pathology, University of Pavia, Italy

    Franco Rilke M.D. (Deputy Director, Director, Professor) (Deputy Director, Director, Professor)

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© 1989 Springer-Verlag Berlin Heidelberg

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Eusebi, V., Cattani, M.G., Ceccarelli, C., Lamovec, J. (1989). Sarcomatoid Carcinomas of the Breast: An Immunocytochemical Study of 14 Cases. In: Cecilia Fenoglio-Preiser, M., Wolff, M., Rilke, F. (eds) Progress in Surgical Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12823-7_5

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  • DOI: https://doi.org/10.1007/978-3-662-12823-7_5

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