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Intracellular Signaling by the ret Tyrosine Kinase

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Genetic Mechanisms in Multiple Endocrine Neoplasia Type 2

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

Abstract

Signaling by receptors with tyrosine kinase activity (RTK) plays an important role in the control of such cellular processes as cell growth, differentiation and motility. The binding of growth factors to RTKs promotes the activation of their intrinsic tyrosine kinase function and their interaction with a repertoire of intracellular molecules that elicit the appropriate biological response.1 In some cases “gain of function” mutations lead to a constitutive activation of the receptor and, as a consequence, to a chronic stimulation of its intracellular signaling pathway.2 Indeed, many members of the RTK gene superfamily were initially isolated as oncogenes that arose from mutations deregulating their kinase activity. Ret, a member of the RTK family, was first isolated as a transforming gene created by a recombination with the rfp gene during transfection of a T cell lymphoma DNA.

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Authors
  1. Alfredo Fusco
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  2. Giancarlo Vecchio
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  3. Nina A. Dathan
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  4. Francesca Carlomagno
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  5. Pier Paolo Di Fiore
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  6. Massimo Santoro
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© 1996 Springer-Verlag Berlin Heidelberg

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Fusco, A., Vecchio, G., Dathan, N.A., Carlomagno, F., Di Fiore, P.P., Santoro, M. (1996). Intracellular Signaling by the ret Tyrosine Kinase. In: Genetic Mechanisms in Multiple Endocrine Neoplasia Type 2. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21948-5_3

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  • DOI: https://doi.org/10.1007/978-3-662-21948-5_3

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