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SCID-hu Mice as a Model for the Study of Human Malignancies

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Human Hematopoiesis in SCID Mice

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

Despite recent advances in the study of human leukemias, and related fields of research such as molecular biology, immunology, and cell biology, the biology of this heterogeneous disease has not yet been completely elucidated. In addition to the mechanisms of leukemogenesis, questions remain regarding the events involved in tumor progression from a preleukemic stage, the regulation of leukemic cell growth by the bone marrow microenvironment, the effects of leukemic cells on normal hematopoiesis, the abnormalities in the leukemic bone marrow microenvironment, the identification of “leukemic stem” cells, and the mechanisms of graft-versus-leukemia (GVL) effects. These questions are difficult to address without experimental animal systems capable of modeling the complex in vivo events of leukemogenesis and leukemias. Models to develop new therapeutic modalities such as cytokine treatment, differentiation induction therapy, and gene therapy are also required.

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Authors
  1. Reiko Namikawa
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© 1995 Springer-Verlag Berlin Heidelberg

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Namikawa, R. (1995). SCID-hu Mice as a Model for the Study of Human Malignancies. In: Human Hematopoiesis in SCID Mice. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22008-5_8

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  • DOI: https://doi.org/10.1007/978-3-662-22008-5_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22010-8

  • Online ISBN: 978-3-662-22008-5

  • eBook Packages: Springer Book Archive

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