Abstract
Neural transplantation is a field extensively researched from as early as the beginning of the twentieth century. Studies have been conducted with three broadly defined objectives and have evolved chronologically as follows: (1) the use of transplants (both neuronal and extraneuronal) simply to assess the viability of “nerve grafts,” and as a tool for studying regeneration in the central nervous system; (2) studies centering on neural transplantation as a method for elucidating the phenomena of neuronal migration and specificity and the relationship of these events to the ordering of the CNS during embryogenesis; and (3) neural transplantation from the standpoint of a technically viable and specialized field of research, with emphasis on the anatomical, functional, and physiological nature of the transplants. It has been in the context of this latter domain that the clinical implications of transplantation work have recently received considerable attention. A review of the primary studies carried out in these three general subgroups follows.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bures, J., Burresova, D., Huston, J. (1976). Techniques and Basic Experiments for the Study of Brain and Behavior. Amsterdam: Elsevier Scientific Publishing Co.
Björklund, A., Segal, M., Stenevi, U. (1979). Functional reinnervation of rat hippocampus by locus coeruleus implants. Brain Res. 170, (pt 3) 409–426.
Björklund, A., Stenevi, U. (1979). Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res. 177, 555–560.
Castro, A. (1972). The effects of cortical ablations on digital usage in the rat. Brain Res. 37, 173–185.
D’Amato, C., Hicks, S. (1980). Development of the motor system: Effects of radiation on developing corticospinal neurons and locomotor function. Exp. Neurol. 70, 1–23.
Das, G.D. (1973). Transplantation of cerebellar tissue in the cerebellum of neonate rabbits. Brain Res. 50, 170–173.
Das, G.D. (1974). Transplantation of embryonic neural tissue in the mammalian brain. I. Growth and differentiation of neuroblasts from various regions of the embryonic brain in the cerebellum of neonate rats. TIT J. Life Sci. 4, 93–124.
Das, G.D. (1975). Differentiation of dendrites in the transplanted neuroblasts in the mammalian brain. In: Advances in Neurology, Vol. 12. Kreutzberg, G.W. (ed.). New York: Raven Press.
Das, G.D. (1976). Transplantation of neuroblasts in the brain of rat: Dendritic differentiation. Anat. Rec. 184, 388.
Das, G.D. (1977). Transplantation of embryonic neural tissue in the brain of the adult rats. Anat. Rec. 187, 563.
Das, G.D. (1978). Neural transplants in the brain of the rat: Nature of degenerative changes in the host brain and the transplant. Anat. Rec. 193, 517.
Das, G.D. (1981). Neural transplants in the spinal cord of the adult rat. Anat. Rec. 199, 64A.
Das, G.D. (1982). Extraparenchymal neural transplants: Their cytology and survivability. Brain Res. 241, 182–186.
Das, G.D., Altman, J. (1971). Transplanted precursors of nerve cells: Their fate in the cerebellums of young rats. Science 173, 637–638.
Das, G.D., Altman, J. (1972). Studies on the transplantation of developing neural tissue in the mammalian brain. I. Transplantation of cerebellar slabs into cerebellum of neonate rats. Brain Res. 38, 233–249.
Das, G.D., Hallas, B. (1978). Transplantation of brain tissue in the brain of adult rats. Experientia, 34, 1304–1306.
Das, G.D., Hallas, B., Das, K. (1979). Transplantation of neural tissue in the brains of laboratory mammals: Technical details and comments. Experientia, 35, 143–153.
Das, G.D., Hallas, B., Das, K. (1980). Transplantation of brain tissue in the brain of rat. I. Growth characteristics of neocortical transplants from embryos of different ages. Am. J. Anat. 158, 135–146.
Dunn, E. (1917). Primary and secondary findings in a series of attempts to transplant cerebral cortex in the albino rat. J. Comp. Neurol. 27, 565–582.
Gash, D., Roos, T., Chambers, W. (1975). Development of Rathke’s pouch tissue transplanted into adult hypophysectomized female rats. Neuroendocrinology 19, 214–226.
Gash, D., Sladek, J., Sladek, C. (1979). Development of normal fetal supraoptic neurons grafted into adult rats with a congenital lack of vasopressin producing neurons. Soc. Neurosci. Abst. 5, 445.
Gentile, A.M., Green, S., Nieburgs, A., Schmelzer, W., Stein, D.G. (1978). Disruption and recovery of locomotor and manipulatory behavior following cortical lesions in rats. Behay. Bio. 22, 417–455.
Glees, P. (1955). Studies on cortical regeneration with special reference to cerebral implants. In: Regeneration in the Central Nervous System. Windle, W.F. (ed.). Springfield, IL: C.C. Thomas.
Hall, R., Lindholm, E. (1974). Organization of motor and somatosensory neocortex in the albino rat. Brain Res. 66, 23–38.
Hallas, B., Das, G.D., Das, K. (1980a). Transplantation of brain tissue in the brain of rat. II. Growth characteristics of neocortical transplants in hosts of different ages. Am. J. Anat. 158, 147–159.
Hallas, B., Oblinger, M., Das, G. (1980b). Heterotopic neural transplants in the cerebellum of the rat: Their afferents. Brain Res. 196, 242–246.
Harvey, A., Lund, R. (1981). Transplantation of tectal tissue in rats. II. Distribution of host neurons which project to transplants. J. Comp. Neurol. 201, 505–520.
Houle, J., Das, G.D. (1980a). Freezing and transplantation of brain tissue in rats. Experientia 30, 1114–1115.
Houle, J., Das, G.D. (1980b). Freezing of embryonic neural tissue and its transplantation in the rat brain. Brain Res. 192, 570–574.
Jaeger, C., Lund, R. (1978). Development of cerebral cortex transplanted to cerebral
cortex or tectum of newborn rat hosts. Soc. Neurosci. Abst. 4, 116.
Jaeger, C., Lund, R. (1979a). Connections between cerebral cortex transplants and rat
host brain. Soc. Neurosci. Abst. 5, 628.
Jaeger, C., Lund, R. (1979b). Efferent fibers from transplanted cerebral cortex of rats. Brain Res. 165, 338–342.
Jaeger, C., Lund, R. (1980a). Transplantation of embryonic occipital cortex to the brain of newborn rats. An autoradiographic study of transplant histogenesis. Exp. Brain Res. 40, 265–272.
Jaeger, C., Lund, R. (1980b). Transplantation of occipital cortex to the tectal region of newborn rats: A light microscopic study of organization and connectivity of the transplants. J. Comp. Neurol. 194, 571–598.
Jaeger, C., Lund, R. (1981). Transplantation of embryonic occipital cortex to the brain of newborn rats: A Golgi study of mature and developing transplants. J. Comp. Neurol. 200, 213–230.
Kimura, H., McGeer, P., Noda, Y., McGeer, E. (1980). Brain transplants in an animal “model” of Huntington’s disease. Soc. Neurosci. Abst. 6, 688.
Kluver, H., Barrera, E. (1953). A method for the combined staining of cells and fibers in the nervous system. J. Neuropath. Exp. Neurol. 12, 400–403.
Krieg, W. (1946a). Connections of the cerebral cortex. I. The albino rat. A. Topography of the cortical areas. J. Comp. Neurol. 84, 221–275.
Krieg, W. (1946b). Connections of the cerebral cortex. I. The albino rat. B. Structure of the cortical areas. J. Comp. Neurol. 84, 277–324.
Kromer, L. (1980). Glial scar formation in the brain of adult rats is inhibited by implants of embryonic CNS tissue. Soc. Neurosci. Abst. 6, 688.
Lacey, D. (1944). A revised procedure for the calibration of the activity wheel. Am. J. Psych. 57, 411.
Lashley, K. (1921). Studies of cerebral function in learning. No. III. The motor area. Brain 44, 255–285.
Le Gros Clark, W.E. (1940). Neuronal differentiation in implanted foetal cortical tissue. J. Neurol. Psych. (London) 3, 263–272.
Le Gros Clark, W.E. (1942). The problem of neuronal regeneration in the central nervous system. I. The influence of spinal ganglia and nerve fragments grafted in the brain. J. Anat. 77, 20–48.
Le Gros Clark, W.E. (1943). The problem of neuronal regeneration in the central nervous system. II. The insertion of peripheral nerve stumps into the brain. J. Anat. 77, 251–258.
Lund, R., Harvey, A. (1981). Transplantation of tectal tissue in rats. I. Organization of transplants and pattern distribution of host afferents within them. J. Comp. Neurol. 201, 191–209.
Lund, R., Hauschka, S. (1976). Transplanted neural tissue develops connections with host rat brain. Science 193, 582–584.
Lundberg, J., Mollgard, K. (1979). Mitotic activity in adult rat brain induced by implantation of pieces of fetal rat brain and liver. Neurosci. Lett. 13, 265–270.
Maier, N. (1935). The cortical area concerned with coordinated walking in the rat. J. Comp. Neurol. 61, 395–405.
McLoon, S., Lund, R. (1979). Development of retina transplanted to the tectum of neonatal rats. Soc. Neurosci. Abst. 5, 631.
McLoon, S., Lund, R. (1980). Specific projections of retina transplanted to rat brain. Exp. Brain Res. 40, 273–282.
McLoon, L., McLoon, S., Lund, R. (1981). Cultured embryonic retinae transplanted to rat brain: Differentiation and formation of projections to host superior colliculus. Brain Res. 226, 15–31.
Oblinger, M., Das, G.D. (1981). Age of host as an influencing factor on the growth and connectivity of neural transplants in the cerebellar hemisphere of the rat. Anat. Rec. 199, 185A - 186A.
Oblinger, M., Hallas, B., Das, G.D. (1980). Neocortical transplants in the cerebellum of the rat: Their afferents and efferents. Brain Res. 189, 228–232.
Perlow, M., Freed, W., Karoum, D., Hoffer, B., Seiger, A., Olson, L., Wyatt, R. (1979). Substantia nigra grafts reduce motor abnormalities produced by destruction of negro-striatal dopamine system. Soc. Neurosci. Abst. 5, 681.
Price, A., Fowler, S. (1981). Deficits in contralateral and ipsilateral forepaw motor control following unilateral motor cortical ablations in rats. Brain Res. 205, 81–90.
Ramon y Cajal, S. (1928). Degeneration and Regeneration of the Nervous System, Vols. 1 and 2. May, R.M. (trans. and ed.). London: Oxford University Press.
Ranson, S. (1903). On the medullated nerve fibers crossing the site of lesions in the brain of the white rat. Comp. Neurol. 13, 185–207.
Ranson, S. (1914). Transplantation of the spinal ganglion, with observations on the significance of complex types of spinal ganglion cells. J. Comp. Neurol. 24, 547–558.
Saltykow, S. (1905). Versuche uber Gehirnplantation, zugleich ein Beitrag zur Kenntniss der Vorgange an den Zelligen Gehirnelementen. Arch. Psych. (Berlin) 40, 329–388.
Settlage, P., Bingham, W., Suckle, H., Borge, A., Woolsey, C. (1949). The pattern of localization in the motor cortex of rat. Fed. Proc. 8, 114.
Spiliotis, P., Thompson, R. (1973). The “manipulative response memory system” in the white rat. Physiol. Psych. 1, 101–114.
Stenevi, U., Björklund, A., Svendgaard, N. (1976). Transplantation of central and peripheral monamine neurons to the adult rat brain: Techniques and conditions for survival. Brain Res. 114, 1–20.
Svendgaard, N. (1977). Transplantation of monoaminergic neurons to the adult rat brain: Conditions for survival and mode of growth. Acta Neurochir. 37, 302.
Tidd, C.W. (1932). The transplantation of spinal ganglion of the white rat. A study of the morphological changes in surviving cells. J. Comp. Neurol. 55, 531–543.
Tupper, D., Wallace, R. (1980). Utility of the neurological examination in rats. Acta
Neurobiol. Exp. 40, 999–1003.
Wallace, R., Das, G.D. (1982). Behavioral effects of CNS transplants in the rat. Brain Res. 243, 133–139.
Weinberg, E., Raine, C. (1980). Reinnervation of peripheral nerve segments implanted into the rat central nervous system. Brain Res. 198, 1–11.
Wenzel, J., Barlehner, F. (1969). Zur regeneration des Cortex cerebri bei Mus masculus. II. Morphologische Befunde regenerativer Vorgange nach Replantation eines Cortexabschnittes. Z. Mikroskop. Forsch. 81, 32–70.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer Science+Business Media New York
About this chapter
Cite this chapter
Harnsberger, J., Wallace, R.B. (1986). A Behavioral and Histological Examination of Young Rats Receiving Homotopic Embryonic Neural Transplants in Motor Cortex. In: Das, G.D., Wallace, R.B. (eds) Neural Transplantation and Regeneration. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25264-2_12
Download citation
DOI: https://doi.org/10.1007/978-3-662-25264-2_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-96160-4
Online ISBN: 978-3-662-25264-2
eBook Packages: Springer Book Archive