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Molecular Genetics of the Class III Region of the HLA Complex

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Immunobiology of HLA

Abstract

The class III region of the HLA complex is located between the class I and class II regions. Whereas HLA class I and class II genes encode sets of structurally related, highly polymorphic transplantation antigens, the class III region consists of at least four types of genes, only two of which have obvious functions in the immune system. Unlike the highly polymorphic class I and II genes, class III genes display a low to moderate degree of genetic variability, but are nevertheless subject to evolutionary mechanisms observed elsewhere in the HLA complex, including gene conversions and changes in gene copy number due to unequal crossing-over during meiosis.

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Authors
  1. Perrin C. White
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Editors and Affiliations

  1. Sloan-Kettering Institute for Cancer Research, Cornell University Graduate School of Medical Science, 10021, New York, New York, USA

    Bo Dupont (Member, Professor of Immunology) (Member, Professor of Immunology)

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White, P.C. (1989). Molecular Genetics of the Class III Region of the HLA Complex. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_6

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  • DOI: https://doi.org/10.1007/978-3-662-39946-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-38980-5

  • Online ISBN: 978-3-662-39946-0

  • eBook Packages: Springer Book Archive

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