Abstract
Adaptive optics imaging enables the observation of microscopic structures of the retina, such as photoreceptors and the arteriolar wall, and more generally increases the overall resolution and contrast of fundus images. We present here clinical applications of AO flood imaging for the management of age-related macular degeneration and arterial hypertension. A promising application is the monitoring of therapy at a short time scale, since AO can detect minute disease-related changes.
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References
Liang J, Williams DR, Miller DT. Supernormal vision and high-resolution retinal imaging through adaptive optics. J Opt Soc Am A. 1997;14(11):2884–92.
Gocho K, Sarda V, Falah S, Sahel JA, Sennlaub F, Benchaboune M, et al. Adaptive optics imaging of geographic atrophy. Invest Ophthalmol Vis Sci. 2013;54:3673–80.
Buus NH, Mathiassen ON, Fenger-Grøn M, Præstholm MN, Sihm I, Thybo NK, et al. Small artery structure during antihypertensive therapy is an independent predictor of cardiovascular events in essential hypertension. J Hypertens. 2013;31:791–7.
Wong TY, Klein R, Sharrett AR, Duncan BB, Couper DJ, Klein BE, et al. Atherosclerosis Risk in Communities Study. Retinal arteriolar diameter and risk for hypertension. Ann Intern Med. 2004;140:248–55.
Wong TY, Klein R, Nieto FJ, Klein BE, Sharrett AR, Meuer SM, et al. Retinal microvascular abnormalities and 10-year cardiovascular mortality: a population-based case–control study. Ophthalmology. 2003;110:933–40.
Lindley RI, Wang JJ, Wong MC, Mitchell P, Liew G, Hand P, et al. Multi-Centre Retina and Stroke Study (MCRS) Collaborative Group. Retinal microvasculature in acute lacunar stroke: a cross-sectional study. Lancet Neurol. 2009;8:628–34.
Koch E, Rosenbaum D, Brolly A, Sahel JA, Chaumet-Riffaud P, Girerd X, Rossant F, Paques M. Morphometric analysis of small arteries in the human retina using adaptive optics imaging: relationship with blood pressure and focal vascular changes. J Hypertens. 2014;32:890–8.
Heagerty AM. Predicting hypertension complications from small artery structure. J Hypertens. 2007;25:939–40.
Seitz R. The retinal vessels: comparative ophthalmoscopic and histologic studies on healthy and diseased eye. Translated by Frederick C. Blodi. Saint-Louis: CV Mosby; 1964.
Jefferies P, Clemett R, Day T. An anatomical study of retinal arteriovenous crossings and their role in the pathogenesis of retinal branch vein occlusions. Aust N Z J Ophthalmol. 1993;21:213–7.
Kimura T, Mizota A, Fujimoto N, Tsuyama Y. Light and electron microscopic studies on human retinal blood vessels of patients with sclerosis and hypertension. Int Ophthalmol. 2005;4:151–8.
Schmitz-Valckenberg S, Lara D, Nizari S, Normando EM, Guo L, Wegener AR, et al. Localisation and significance of in vivo near-infrared autofluorescent signal in retinal imaging. Br J Ophthalmol. 2011;95:1134–9.
Cherepanoff S, McMenamin P, Gillies MC, Kettle E, Sarks SH. Bruch’s membrane and choroidal macrophages in early and advanced age-related macular degeneration. Br J Ophthalmol. 2010;94:918–25.
Paques M, Simonutti M, Augustin S, Goupille O, El Mathari B, Sahel JA. In vivo observation of the locomotion of microglial cells in the retina. Glia. 2010;58:1663–8.
Sarks SH. Ageing and degeneration in the macular region: a clinico-pathological study. Br J Ophthalmol. 1976;60:324–41.
Chui TY, Vannasdale DA, Burns SA. The use of forward scatter to improve retinal vascular imaging with an adaptive optics scanning laser ophthalmoscope. Biomed Opt Express. 2012;10:2537–49.
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Paques, M. (2015). Adaptive Optics Imaging of the Retina and Vessels. In: Michelson, G. (eds) Teleophthalmology in Preventive Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44975-2_7
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DOI: https://doi.org/10.1007/978-3-662-44975-2_7
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