Abstract
A novel experimental approach combining high-resolution cryoelectron microscopy of vitreous tissue section (CEMOVIS) defocus series with electron microscopy simulation was employed to show that the stratum corneum lipid matrix is organized as stacked bilayers of fully extended ceramides with cholesterol molecules associated with the ceramide sphingoid moiety. The new knowledge may serve as a molecular platform for in silico approaches to identify molecules for enhancing skin penetration for percutaneous drug delivery as well as for tightening a leaking barrier in dry skin conditions.
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Norlén, L. (2015). Molecular Structure and Function of the Skin Barrier. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45013-0_4
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DOI: https://doi.org/10.1007/978-3-662-45013-0_4
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