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Association of Candida with Linear Gingival Erythema in HIV-Infected Subjects

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Oral Candidosis

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Abstract

Linear gingival erythema (LGE) in HIV patients has a contentious association with Candida infection. Although now it is widely accepted that Candida contributes to the occurrence of LGE, still some controversy exists in the nature of its association as an aetiological agent. We will briefly discuss the clinical picture of LGE. This will be followed by an update on insight of microbial association with the lesion, prevalence of LGE, diagnosis and treatment. The current hypothesis and proposed mechanism of the LGE are then discussed.

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References

  • Aas JA, Barbuto SM, Alpagot T, Olsen I, Dewhirst FE, Paster BJ (2007) Subgingival plaque microbiota in HIV positive patients. J Clin Periodontol 34(3):189–195

    Article  PubMed  Google Scholar 

  • Adedigba MA, Ogunbodede EO, Jeboda SO, Naidoo S (2008) Patterns of oral manifestation of HIV/AIDS among 225 Nigerian patients. Oral Dis 14(4):341–346

    Article  PubMed  Google Scholar 

  • Aleixo RQ, Scherma AP, Guimaraes G, Cortelli JR, Cortelli SC (2010) DMFT index and oral mucosal lesions associated with HIV infection: cross-sectional study in Porto Velho, Amazonian region – Brazil. Braz J Infect Dis 14(5):449–456

    Article  PubMed  Google Scholar 

  • Armitage GC (1999) Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4(1):1–6

    Article  PubMed  Google Scholar 

  • Axéll T, Azuln AM, Challacombet SJ, Ficarra G, Flint S, Greenspan D, Hammerle C, Laskaris G, Loeb I, Lucas-Tomas M, Monteil RA, Pindborg JJ, Riechart P, Robinson P, Scully C, Swango P, Syrjnen S, Thornhill MH, van der Waal I, Williams DM, Wray D (1993) Classification and diagnostic criteria for oral lesions in HIV infection. EC-clearinghouse on oral problems related to HIV infection and WHO collaborating centre on oral manifestations of the immunodeficiency virus. J Oral Pathol Med 22(7):289–291

    Article  Google Scholar 

  • Barasch A, Safford MM, Catalanotto FA, Fine DH, Katz RV (2000) Oral soft tissue manifestations in HIV-positive vs. HIV-negative children from an inner city population: a two-year observational study. Pediatr Dent 22(3):215–220

    PubMed  Google Scholar 

  • Begg MD, Lamster IB, Panageas KS, Mitchell-Lewis D, Phelan JA, Grbic JT (1997) A prospective study of oral lesions and their predictive value for progression of HIV disease. Oral Dis 3(3):176–183

    Article  PubMed  Google Scholar 

  • Bodhade AS, Ganvir SM, Hazarey VK (2011) Oral manifestations of HIV infection and their correlation with CD4 count. J Oral Sci 53(2):203–211

    Article  PubMed  Google Scholar 

  • Ceballos-Salobrena A, Gaitain-Cepeda L, Ceballos-Garcia L, Samaranayake LP (2004) The effect of antiretroviral therapy on the prevalence of HIV-associated oral candidiasis in a Spanish cohort. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97(3):345–350

    Article  PubMed  Google Scholar 

  • Cerqueira DF, Portela MB, Pomarico L, de Araujo Soares RM, de Souza IP, Castro GF (2010) Oral Candida colonization and its relation with predisposing factors in HIV-infected children and their uninfected siblings in Brazil: the era of highly active antiretroviral therapy. J Oral Pathol Med 39(2):188–194

    Article  PubMed  Google Scholar 

  • Cheng SC, Joosten LA, Kullberg BJ, Netea MG (2012) Interplay between Candida albicans and the mammalian innate host defense. Infect Immun 80(4):1304–1313

    Article  PubMed Central  PubMed  Google Scholar 

  • Chiang CP, Chueh LH, Lin SK, Chen MY (1998) Oral manifestations of human immunodeficiency virus-infected patients in Taiwan. J Formos Med Assoc 97(9):600–605

    PubMed  Google Scholar 

  • Coogan MM, Greenspan J, Challacombe SJ (2005) Oral lesions in infection with human immunodeficiency virus. Bull World Health Organ 83(9):700–706

    PubMed Central  PubMed  Google Scholar 

  • de Aguiar Ribeiro A, Portela MB, de Souza IP (2013) The oral health of HIV-infected Brazilian children. Int J Paediatr Dent 23(5):359–365

    Article  PubMed  Google Scholar 

  • Duggal MS, Abudiak H, Dunn C, Tong HJ, Munyombwe T (2010) Effect of CD4+ lymphocyte count, viral load, and duration of taking anti-retroviral treatment on presence of oral lesions in a sample of South African children with HIV+/AIDS. Eur Arch Paediatr Dent 11(5):242–6

    Google Scholar 

  • Fine DH, Tofsky N, Nelson EM, Schoen D, Barasch A (2003) Clinical implications of the oral manifestations of HIV infection in children. Dent Clin North Am 47(1):159–174, xi-xii

    Article  PubMed  Google Scholar 

  • Flaitz C, Wullbrandt B, Sexton J, Bourdon T, Hicks J (2001) Prevalence of orodental findings in HIV-infected Romanian children. Pediatr Dent 23(1):44–50

    PubMed  Google Scholar 

  • Fonseca R, Cardoso AS, Pomarico I (2000) Frequency of oral manifestations in children infected with human immunodeficiency virus. Quintessence Int 31(6):419–422

    PubMed  Google Scholar 

  • Freeman AD, Liberali SA, Coates EA, Logan RM (2012) Oral health in Australian HIV patients since the advent of combination antiretroviral therapy. Aust Dent J 57(4):470–476, quiz 518

    Article  PubMed  Google Scholar 

  • Gomez RS, da Costa JE, Loyola AM, de Araujo NS, de Araujo VC (1995) Immunohistochemical study of linear gingival erythema from HIV-positive patients. J Periodontal Res 30(5):355–359

    Article  PubMed  Google Scholar 

  • Goncalves LS, Soares Ferreira SM, Souza CO, Souto R, Colombo AP (2007) Clinical and microbiological profiles of human immunodeficiency virus (HIV)-seropositive Brazilians undergoing highly active antiretroviral therapy and HIV-seronegative Brazilians with chronic periodontitis. J Periodontol 78(1):87–96

    Article  PubMed  Google Scholar 

  • Goncalves LS, Goncalves BM, Fontes TV (2013) Periodontal disease in HIV-infected adults in the HAART era: clinical, immunological, and microbiological aspects. Arch Oral Biol 58(10):1385–1396

    Article  PubMed  Google Scholar 

  • Grbic JT, Mitchell-Lewis DA, Fine JB, Phelan JA, Bucklan RS, Zambon JJ, Lamster IB (1995) The relationship of candidiasis to linear gingival erythema in HIV-infected homosexual men and parenteral drug users. J Periodontol 66(1):30–37

    Article  PubMed  Google Scholar 

  • Grbic JT, Lamster IB, Mitchell-Lewis D (1997) Inflammatory and immune mediators in crevicular fluid from HIV-infected injecting drug users. J Periodontol 68(3):249–255

    Article  PubMed  Google Scholar 

  • Guteta S, Feleke Y, Fekade D, Neway M, Diro E (2008) Prevalence of oral and perioral manifestations in HIV positive adults at Tikur Anbessa Teaching Hospital Addis Ababa, Ethiopia. Ethiop Med J 46(4):349–357

    PubMed  Google Scholar 

  • Hofer D, Hammerle CH, Grassi M, Lang NP (2002) Long-term results of supportive periodontal therapy (SPT) in HIV-seropositive and HIV-seronegative patients. J Clin Periodontol 29(7):630–637

    Article  PubMed  Google Scholar 

  • Hofman P, Fischer F, Far DF, Selva E, Battaglione V, Bayle J, Rossi B (1999) Impairment of HIV polymorphonuclear leukocyte transmigration across T84 cell monolayers: an alternative mechanisms for increased intestinal bacterial infections in AIDS? Eur Cytokine Netw 10(3):373–382

    PubMed  Google Scholar 

  • Khatibi M, Moshari AA, Jahromi ZM, Ramezankhani A (2011) Prevalence of oral mucosal lesions and related factors in 200 HIV+/AIDS Iranian patients. J Oral Pathol Med 40(8):659–664

    Article  PubMed  Google Scholar 

  • Khongkunthian P, Grote M, Isaratanan W, Plyaworawong S, Reichart PA (2001) Oral manifestations in HIV-positive adults from Northern Thailand. J Oral Pathol Med 30(4):220–223

    Article  PubMed  Google Scholar 

  • Klein RS, Quart AM, Small CB (1991) Periodontal disease in heterosexuals with acquired immunodeficiency syndrome. J Periodontol 62(8):535–540

    Article  PubMed  Google Scholar 

  • Kroidl A, Schaeben A, Oette M, Wettstein M, Herfordt A, Haussinger D (2005) Prevalence of oral lesions and periodontal diseases in HIV-infected patients on antiretroviral therapy. Eur J Med Res 10(10):448–453

    PubMed  Google Scholar 

  • Lamster IB, Begg MD, Mitchell-Lewis D, Fine JB, Grbic JT, Todak GG, el-Sadr W, Gorman JM, Zambon JJ, Phelan JA (1994) Oral manifestations of HIV infection in homosexual men and intravenous drug users. Study design and relationship of epidemiologic, clinical, and immunologic parameters to oral lesions. Oral Surg Oral Med Oral Pathol 78(2):163–174

    Article  PubMed  Google Scholar 

  • Lamster IB, Grbic JT, Mitchell-Lewis DA, Begg MD, Mitchell A (1998) New concepts regarding the pathogenesis of periodontal disease in HIV infection. Ann Periodontol 3(1):62–75

    Article  PubMed  Google Scholar 

  • Machado FC, de Souza IP, Portela MB, de Araujo Soares RM, Freitas-Fernandes LB, Castro GF (2011) Use of chlorhexidine gel (0.2%) to control gingivitis and candida species colonization in human immunodeficiency virus-infected children: a pilot study. Pediatr Dent 33(2):153–157

    PubMed  Google Scholar 

  • Margiotta V, Campisi G, Mancuso S, Accurso V, Abbadessa V (1999) HIV infection: oral lesions, CD4+ cell count and viral load in an Italian study population. J Oral Pathol Med 28(4):173–177

    Article  PubMed  Google Scholar 

  • Mataftsi M, Skoura L, Sakellari D (2011) HIV infection and periodontal diseases: an overview of the post-HAART era. Oral Dis 17(1):13–25

    Article  PubMed  Google Scholar 

  • Miziara ID, Filho BC, Weber R (2006) Oral lesions in Brazilian HIV-infected children undergoing HAART. Int J Pediatr Otorhinolaryngol 70(6):1089–1096

    Article  PubMed  Google Scholar 

  • Naglik JR, Moyes DL, Wachtler B, Hube B (2011) Candida albicans interactions with epithelial cells and mucosal immunity. Microbes Infect 13(12-13):963–976

    Article  PubMed Central  PubMed  Google Scholar 

  • Naidu GS, Thakur R, Singh AK, Rajbhandary S, Mishra RK, Sagtani A (2013) Oral lesions and immune status of HIV infected adults from eastern Nepal. J Clin Exp Dent 5(1):e1–7

    Google Scholar 

  • Nesti M, Carli E, Giaquinto C, Rampon O, Nastasio S, Giuca MR (2012) Correlation between viral load, plasma levels of CD4–CD8 T lymphocytes and AIDS-related oral diseases: a multicentre study on 30 HIV+ children in the HAART era. J Biol Regul Homeost Agents 26(3):527–537

    PubMed  Google Scholar 

  • Nittayananta W, Chanowanna N, Sripatanakul S, Winn T (2001) Risk factors associated with oral lesions in HIV-infected heterosexual people and intravenous drug users in Thailand. J Oral Pathol Med 30(4):224–230

    Article  PubMed  Google Scholar 

  • Odden K, Schenck K, Koppang H, Hurlen B (1994) Candidal infection of the gingiva in HIV-infected persons. J Oral Pathol Med 23(4):178–183

    Article  PubMed  Google Scholar 

  • Patton LL (2000) Sensitivity, specificity, and positive predictive value of oral opportunistic infections in adults with HIV/AIDS as markers of immune suppression and viral burden. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90(2):182–188

    Article  PubMed  Google Scholar 

  • Phelan JA (1997) Dental lesions: diagnosis and treatment. Oral Dis 3(Suppl 1):S235–S237

    Article  PubMed  Google Scholar 

  • Pongsiriwet S, Iamaroon A, Kanjanavanit S, Pattanaporn K, Krisanaprakornkit S (2003) Oral lesions and dental caries status in perinatally HIV-infected children in Northern Thailand. Int J Paediatr Dent 13(3):180–185

    Article  PubMed  Google Scholar 

  • Portela MB, Souza IP, Costa EM, Hagler AN, Soares RM, Santos AL (2004) Differential recovery of Candida species from subgingival sites in human immunodeficiency virus-positive and healthy children from Rio de Janeiro, Brazil. J Clin Microbiol 42(12):5925–5927

    Article  PubMed Central  PubMed  Google Scholar 

  • Portela MB, Souza IP, Abreu CM, Bertolini M, Holandino C, Alviano CS, Santos AL, Soares RM (2010) Effect of serine-type protease of Candida spp. isolated from linear gingival erythema of HIV-positive children: critical factors in the colonization. J Oral Pathol Med 39(10):753–760

    Article  PubMed  Google Scholar 

  • Portela MS, de Cerqueira DFM, Araujo S, Castro GF (2012) Candida spp. in linear gingival erythema lesions in HIV-infected children: reports of six cases. Inter J Sci Dentist 51–55

    Google Scholar 

  • Ramos-Gomez F (2002) Dental considerations for the paediatric AIDS/HIV patient. Oral Dis 8(Suppl 2):49–54

    Article  PubMed  Google Scholar 

  • Ranganathan AT, Saraswathi PK, Albert V, Baba MG, Panishankar KH (2012) Route of transmission might influence the clinical expression of periodontal lesions in “human immunodeficiency virus” positive patients. Niger J Clin Pract 15(3):349–353

    Article  PubMed  Google Scholar 

  • Reichart PA (2003) Oral manifestations in HIV infection: fungal and bacterial infections, Kaposi’s sarcoma. Med Microbiol Immunol 192(3):165–169

    Article  PubMed  Google Scholar 

  • Reznik DA (2005) Oral manifestations of HIV disease. Top HIV Med 13(5):143–148

    PubMed  Google Scholar 

  • Ryder MI, Nittayananta W, Coogan M, Greenspan D, Greenspan JS (2012) Periodontal disease in HIV/AIDS. Periodontol 2000 60(1):78–97

    Article  PubMed  Google Scholar 

  • Samaranayake LP, Fidel PL, Naglik JR, Sweet SP, Teanpaisan R, Coogan MM, Blignaut E, Wanzala P (2002) Fungal infections associated with HIV infection. Oral Dis 8(Suppl 2):151–160

    Article  PubMed  Google Scholar 

  • Samaranayake LP, Keung Leung W, Jin L (2009) Oral mucosal fungal infections. Periodontol 2000(49):39–59

    Article  Google Scholar 

  • Schoen DH, Murray PA, Nelson E, Catalanotto FA, Katz RV, Fine DH (2000) A comparison of periodontal disease in HIV-infected children and household peers: a two year report. Pediatr Dent 22(5):365–369

    PubMed  Google Scholar 

  • Shalekoff S, Tiemessen CT, Gray CM, Martin DJ (1998) Depressed phagocytosis and oxidative burst in polymorphonuclear leukocytes from individuals with pulmonary tuberculosis with or without human immunodeficiency virus type 1 infection. Clin Diagn Lab Immunol 5(1):41–44

    PubMed Central  PubMed  Google Scholar 

  • Sharma G, Pai KM, Setty S, Ramapuram JT, Nagpal A (2009) Oral manifestations as predictors of immune suppression in a HIV-/AIDS-infected population in south India. Clin Oral Investig 13(2):141–148

    Article  PubMed  Google Scholar 

  • Sontakke SA, Umarji HR, Karjodkar F (2011) Comparison of oral manifestations with CD4 count in HIV-infected patients. Indian J Dent Res 22(5):732

    Article  PubMed  Google Scholar 

  • Taiwo OO, Hassan Z (2010) The impact of highly active antiretroviral therapy (HAART) on the clinical features of HIV-related oral lesions in Nigeria. AIDS Res Ther 7:19

    Article  PubMed Central  PubMed  Google Scholar 

  • Umadevi M, Adeyemi O, Patel M, Reichart PA, Robinson PG (2006) (B2) Periodontal diseases and other bacterial infections. Adv Dent Res 19(1):139–145

    Article  PubMed  Google Scholar 

  • van der Waal I (1997) Some unusual oral lesions in HIV infection: comments on the current classification. Oral Dis 3(Suppl 1):S197–S199

    Article  PubMed  Google Scholar 

  • Velegraki A, Nicolatou O, Theodoridou M, Mostrou G, Legakis NJ (1999) Paediatric AIDS–related linear gingival erythema: a form of erythematous candidiasis? J Oral Pathol Med 28(4):178–182

    Article  PubMed  Google Scholar 

  • Winkler JR, Murray PA (1987) Periodontal disease. A potential intraoral expression of AIDS may be rapidly progressive periodontitis. CDA J 15(1):20–24

    PubMed  Google Scholar 

  • Zambon JJ, Reynolds HS, Genco RJ (1990) Studies of the subgingival microflora in patients with acquired immunodeficiency syndrome. J Periodontol 61(11):699–704

    Article  PubMed  Google Scholar 

  • Zhang X, Reichart PA, Song Y (2009) Oral manifestations of HIV/AIDS in China: a review. Oral Maxillofac Surg 13(2):63–68

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore, Singapore

    Chaminda Jayampath Seneviratne

  2. Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka

    Ruwan Duminda Jayasinghe

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  1. Chaminda Jayampath Seneviratne
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  2. Ruwan Duminda Jayasinghe
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Correspondence to Chaminda Jayampath Seneviratne .

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  1. School of Health and Biosciences, Pontifical Catholic University of Paraná, Curitiba, Paraná, Brazil

    Edvaldo Antonio Ribeiro Rosa

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Seneviratne, C.J., Jayasinghe, R.D. (2015). Association of Candida with Linear Gingival Erythema in HIV-Infected Subjects. In: Ribeiro Rosa, E. (eds) Oral Candidosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47194-4_12

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  • DOI: https://doi.org/10.1007/978-3-662-47194-4_12

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