Abstract
ART acts on tumor cells differentially by the threshold concentrations. High-dose ART kills tumor cells upon the inhibition of NOS, whereas low-dose ART benefits tumor propagation due to induce cytoprotective NO production. Pro-oxidants that antagonize antioxidants can potentiate ART’s antitumor capacity. The combination of ART with pro-oxidants should provide an effective solution to the chemotherapy of multidrug resistant tumors.
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Zeng, QP. (2015). ART for Antitumor. In: Artemisinin and Nitric Oxide. SpringerBriefs in Molecular Science. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47688-8_3
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DOI: https://doi.org/10.1007/978-3-662-47688-8_3
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