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Recent Advances in Cartilage Repair (ICL 3)

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Abstract

Articular cartilage possesses low intrinsic healing property due to its lack of vascularity and progenitor cells. Thus, damage to the hyaline cartilage may lead to a progressive degeneration of the joint and eventually to osteoarthritis (OA). In the last years, different surgical techniques have been introduced in the clinical practice to overcome this issue. Bone marrow stimulation, for example, is a widely known method to allow cell invasion from the bloodstream to the site of damage. However, the reparative tissue has different morphological and biomechanical properties when compared to the native cartilage. In particular, the newly formed fibrocartilage has a low amount of proteoglycans and a higher concentration of type I collagen. This different matrix composition leads to a decrease in the mechanical strength and to a poor integration of the reparative tissue with the native cartilage.

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Authors and Affiliations

  1. Department of Biomedical Sciences for Health, University of Milan, Milan, Italy, IRCCS Istituto Ortopedico Galeazzi, via R. Galeazzi, 4, Milan, Italy

    Giuseppe M. Peretti & Laura Mangiavini

  2. Department of Trauma Surgery, University Medical Center Regensburg, Regensburg, Germany

    Peter Angele MD, Prof

  3. Biomechanics Laboratory – II Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy

    Giuseppe Filardo & Elizaveta Kon

  4. Department of Orthopaedics and Traumatology, University of Torino, Torino, Italy

    Antongiulio Marmotti

  5. Molecular Biotechnology Center, University of Torino, Turin, Italy

    Silvia Mattia

  6. LEKMED, Hospital Kartezjusza, Warszawa, Poland

    Konrad Slynarski

  7. ITRT, Centro Médico Teknon, Barcelona, Spain

    Francesc Soler

  8. Division of Rheumatology, University Hospitals Leuven, Leuven, Belgium

    Dieter Van Assche

  9. Center of Experimental Orthopaedics, Saarland University, Homburg, Germany

    Henning Madry

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  1. Giuseppe M. Peretti
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Correspondence to Giuseppe M. Peretti or Henning Madry .

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Editors and Affiliations

  1. Med.Dir.Uni.Hosp.Brande."The.Fon.Med.Sch, Dept.ofOrtho.&Traumato.Cen.of Jt.Replac., Brandenburg, Brandenburg, Germany

    Roland Becker

  2. Academic Medical Center, Orthopaedic Surgery, AZ Amsterdam, The Netherlands

    Gino M.M.J. Kerkhoffs

  3. Universitat Autònoma de Barcelona, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

    Pablo E. Gelber

  4. Istituto Clinico Humanitas, Monza, Italy

    Matteo Denti

  5. Centre Hospitalier de Luxembourg, Clinique d'Eich, Luxembourg, Luxembourg

    Romain Seil

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Peretti, G.M. et al. (2016). Recent Advances in Cartilage Repair (ICL 3). In: Becker, R., Kerkhoffs, G., E. Gelber, P., Denti, M., Seil, R. (eds) ESSKA Instructional Course Lecture Book . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49114-0_3

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