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New Strategies for Muscular Repair and Regeneration

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Muscle and Tendon Injuries

Abstract

Skeletal muscle injuries are common causes of severe long-term pain and physical disability, accounting for up to 55% of all sports injuries. The phases of the healing processes after direct or indirect muscle injury are complex but clearly defined and include well-coordinated steps: degeneration, inflammation, regeneration, and fibrosis. Despite this frequent occurrence and the presence of a body of data on the pathophysiology of muscle injuries, none of the current treatment strategies have been shown to be really effective in strictly controlled trials. Various strategies, including standard protocol as PRICE/POLICE, fisiochinesiterapic treatment, kinesiotaping, mechanical stimulation, growth factor injections, transplantation of muscle stem cells in combination or not with biological scaffolds, and anti-fibrotic therapies, may become therapeutic alternatives to improve functional muscle recovery.

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Authors and Affiliations

  1. Department of Clinical and Molecular Sciences, School of Medicine, Università Politecnica delle Marche, Via Tronto 10/60126, Ancona, Italy

    M. Cianforlini, V. Coppa, M. Grassi & A. Gigante

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  1. M. Cianforlini
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  2. V. Coppa
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  3. M. Grassi
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  4. A. Gigante
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Correspondence to A. Gigante .

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Editors and Affiliations

  1. Koelliker Hospital, Centre of Sports Traumatology, Torino, Italy

    Gian Luigi Canata

  2. Dept. of Orthopaedic Surgery, Aspetar Hospital Aspire Zone, Doha, Qatar

    Pieter d'Hooghe

  3. Department of Orthopedics, University of Colorado Hospital, Aurora, Colorado, USA

    Kenneth J. Hunt

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Cianforlini, M., Coppa, V., Grassi, M., Gigante, A. (2017). New Strategies for Muscular Repair and Regeneration. In: Canata, G., d'Hooghe, P., Hunt, K. (eds) Muscle and Tendon Injuries. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54184-5_14

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