Skip to main content

Hämatopoetische Tumoren

  • Chapter
  • First Online:
Veterinäronkologie kompakt
  • 737 Accesses

Zusammenfassung

Lymphatische Tumoren veterinärmedizinischer Patienten gleichen den sogenannten Non-Hodgkin- Lymphomen des Menschen. Sie stellen eine systemische neoplastische Proliferation von Lymphozyten oder deren Vorläuferzellen dar. Trotz der gemeinsamen Bezeichnung dieser Tumoren als Lymphom bilden sie eine sehr heterogene Gruppe von malignen Tumoren mit sehr variablem biologischem Verhalten, da sie von ganz verschiedenen Lymphozytentypen abstammen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Weiterführende Literatur

  • Adam F, Villiers E, Watson S, Coyne K, Blackwood L (2009) Clinical pathological and epidemiological assessment of morphologically and immunologically confirmed canine leukaemia. Vet Comp Oncol 7(3):181–195. 10.1111/j.1476-5829.2009.00189.x

    Article  CAS  PubMed  Google Scholar 

  • Affolter VK, Moore PF (2002) Localized and disseminated histiocytic sarcomas of dendritic cell origin in dogs. Vet Pathol 39(1):74–83

    Article  CAS  PubMed  Google Scholar 

  • Affolter VK, Moore PF (2006) Feline progressive histiocytosis. Vet Pathol 43(5):646–655. 10.1354/vp.43-5-646

    Article  CAS  PubMed  Google Scholar 

  • Aster JC (2004) Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus. In: Kumar v et al. (Hrsg) Robbins and Cotran Pathologic Basis of Disease, 7. Aufl. Elsevier Saunders, Philadelphia, S 661–710

    Google Scholar 

  • Baer K, Patnaik A, Gilbertson S, Hurvitz A (1989) Cutaneous plasmacytomas in dogs: a morphologic and immunohistochemical study. Vet Pathol Online 26(3):216–221

    Article  CAS  Google Scholar 

  • Beatty JA, Lawrence CE, Callanan JJ, Grant CK, Gault EA, Neil JC, Jarrett O (1998) Feline immunodeficiency virus (FIV)-associated Lymphome: a potential role for immune dysfunction in tumourigenesis. Vet Immunol Immunopathol 65(2–4):309–322

    Article  CAS  PubMed  Google Scholar 

  • Bergman PJ (2012) Paraneoplastic hypercalcemia. Top Companion Anim Med 27(4):156–158. doi:http://dx.doi.org/10.1053/j.tcam.2012.09.003

    Article  PubMed  Google Scholar 

  • Bienzle D, Silverstein DC, Chaffin K (2000) Multiple myelomas in cats: variable presentation with different immunoglobulin isotypes in two cats. Vet Pathol 37(4):364–369

    Article  CAS  PubMed  Google Scholar 

  • Breuer W, Colbatzky F, Platz S, Hermanns W (1993) Immunoglobulin-producing tumours in dogs and cats. J Comp Pathol 109(3):203–216

    Article  CAS  PubMed  Google Scholar 

  • Campbell MW, Hess PR, Williams LE (2013) Chronic lymphocytic leukaemia in the cat: 18 cases (2000–2010). Vet Comp Oncol 11(4):256–264. doi:10.1111/j.1476-5829.2011.00315.x

    Article  CAS  PubMed  Google Scholar 

  • Carreras JK, Goldschmidt M, Lamb M, McLear RC, Drobatz KJ, Sorenmo KU (2003) Feline epitheliotropic intestinal malignant lymphomas: 10 cases (1997–2000). J Vet Intern Med 17(3):326–331

    PubMed  Google Scholar 

  • Chun R (2009) Lymphoma: which chemotherapy protocol and why?. Top Companion Anim Med 24(3):157–162. 10.1053/j.tcam.2009.03.003

    Article  PubMed  Google Scholar 

  • Cotter S (1983) Treatment of lymphomas and leukemia with cyclophosphamide, vincristine, and prednisone. II. Treatment of cats. J Am Anim Hosp Assoc 19(2):166–172

    Google Scholar 

  • Couto CG (1985) Clinicopathologic aspects of acute leukemias in the dog. J Am Vet Med Assoc 186(7):681–685

    CAS  PubMed  Google Scholar 

  • Couto CG, Rutgers HC, Sherding RG, Rojko J (1989) Gastrointestinal lymphomas in 20 dogs. A retrospective study. J Vet Intern Med3(2):73–78

    Article  CAS  PubMed  Google Scholar 

  • Curran K, Thamm DH (2015) Retrospective analysis for treatment of naïve canine multicentric lymphoma with a 15-week, maintenance-free CHOP protocol. Vet Comp Oncol Suppl 1:147–155. 10.1111/vco.12163

    Google Scholar 

  • Dobson JM (2013) Breed-predispositions to cancer in pedigree dogs. ISRN Veterinary Science 2013:941275–941275. doi:10.1155/2013/941275

    Article  PubMed  PubMed Central  Google Scholar 

  • Elmslie RE, Ogilvie GK, Gillette EL, McChesney-Gillette S (1991) Radiotherapy with and without chemotherapy for localized lymphoma in 10 cats. Vet Radiol 32(6):277–280. 10.1111/j.1740-8261.1991.tb00121.x

    Article  Google Scholar 

  • Essex ME (1982) Feline leukemia: a naturally occurring cancer of infectious origin. Epidemiol Rev 4:189–203

    Article  CAS  PubMed  Google Scholar 

  • Ester SJ, Mesfin GM (1980) A solitary plasmacytoma in a dog with progression to a disseminated myeloma. Can Vet J 21(10):284–286

    Google Scholar 

  • Fulmer AK, Mauldin GE (2007) Canine histiocytic neoplasia: an overview. Can Vet J 48(10):1041

    PubMed  PubMed Central  Google Scholar 

  • Gross TL, Ihrke PJ, Walder EJ, Affolter VK (Hrsg.) (2008) Lymphocytic tumors. In: Skin diseases of the dog and cat. Blackwell Science Ltd, Oxford, S 866–893. 10.1002/9780470752487.ch37

    Google Scholar 

  • Hadden AG, Cotter SM, Rund W, Moore AS, Davis RM, Morrissey P (2008) Efficacy und toxicosis of VELCAP-C treatment of lymphoma in cats. J Vet Intern Med 22(1):153–157. 10.1111/j.1939-1676.2007.0031.x

    Article  CAS  PubMed  Google Scholar 

  • Haney SM, Beaver L, Turrel J, Clifford CA, Klein MK, Crawford S, Poulson JM, Azuma C (2009) Survival analysis of 97 Katzen mit nasal Lymphome: a multi-institutional retrospective study (1986–2006). J Vet Intern Med 23(2):287–294. 10.1111/j.1939-1676.2008.0243.x

    Article  CAS  PubMed  Google Scholar 

  • Hanna F (2005) Multiple myelomas in cats. J Feline Med Surg 7(5):275–287. doi:10.1016/j.jfms.2004.12.005

    Article  PubMed  Google Scholar 

  • Hardy WD Jr (1981) Haematopoietic tumors of cats. J Am Anim Hosp Assoc 17:921–940

    Google Scholar 

  • Hardy WD Jr, McClellund AJ, Zuckerman EE, HW Jr S, MacEwen EG, Francis D, Essex M (1980) Development of virus non-producer lymphosarcomas in pet cats exposed to FeLV. Nature 288(5786):90–92

    Google Scholar 

  • Hart JR, Shaker E, Patnaik AK, Garvey MS (1994) Lymphocytic-plasmacytic entercololitis in cats: 60 cases (1988–1990). J Am Anim Hosp Assoc 30(5):505–514

    Google Scholar 

  • Hayes HM, Tarone RE, Cantor KP, Jessen CR, McCurnin DM, Richardson RC (1991) Case-control study of canine malignant lymphoma: positive association mit Hundowner’s use of 2,4-dichlorophenoxyacetic acid herbicides. J Natl Cancer Inst 83(17):1226–1231

    Article  CAS  PubMed  Google Scholar 

  • Hedan B, Thomas R, Motsinger-Reif A, Abadie J, Undre C, Cullen J, Breen M (2011) Molecular cytogenetic characterization of canine histiocytic sarcomas: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes und highlights influence of genetic background on tumor behavior. BMC Cancer 11:201. doi:10.1186/1471-2407-11-201

    Article  PubMed  PubMed Central  Google Scholar 

  • Hodgkins EM, Zinkl JG, Madewell BR (1980) Chronic lymphocytic leukemia in the dog. J Am Vet Med Assoc 177(8):704–707

    CAS  PubMed  Google Scholar 

  • Jackson ML, Wood SL, Misra V, Haines DM (1996) Immunohistochemical identification of B und T lymphocytes in formalin-fixed, paraffin-embedded feline lymphosarcomass: relation to feline leukemia virus status, tumor site, und patient age. Can J Vet Res 60(3):199–204

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kupanoff PA, Popovitch CA, Goldschmidt MH (2006) Colorectal plasmacytomas: a retrospective study of nine dogs. J Am Anim Hosp Assoc 42(1):37–43. doi:10.5326/0420037

    Article  PubMed  Google Scholar 

  • Leifer CE, Matus RE (1986) Chronic lymphocytic leukemia in the dog: 22 cases (1974–1984). J Am Vet Med Assoc 189(2):214–217.

    CAS  PubMed  Google Scholar 

  • Lester SJ, Mesfin GM (1980) A solitary plasmacytoma in a dog with progression to a disseminated myeloma. Can Vet J 21 (10):284–286

    CAS  PubMed  PubMed Central  Google Scholar 

  • Little L, Patel R, Goldschmidt M (2007) Nasal und nasopharyngeal lymphomas in cats: 50 cases (1989–2005). Vet Pathol 44(6):885–892

    Article  CAS  PubMed  Google Scholar 

  • Louwerens M, London CA, Pedersen NC, Lyons LA (2005) Feline lymphomas in the post-feline leukemia virus era. J Vet Intern Med 19(3):329–335

    PubMed  Google Scholar 

  • Lucke VM (1987) Primary cutaneous plasmacytomas in the dog and cat. J Small Anim Prac 28(1):49–55. doi:10.1111/j.1748-5827.1987.tb05970.x

    Article  Google Scholar 

  • MacEwen EG, Hurvitz AI (1977) Diagnosis and management of monoclonal gammopathies. Vet Clin North Am 7(1):119–132

    Article  CAS  PubMed  Google Scholar 

  • Marconato L, Gelain ME, Comazzi S (2013) The dog as a possible animal model for human non-Hodgkin lymphomas: a review. Hematol Oncol 31(1):1–9. 10.1002/hon.2017

    Article  CAS  PubMed  Google Scholar 

  • Marioni-Henry K, Van Winkle TJ, Smith SH, Vite CH (2008) Tumors affecting the spinal cord of cats: 85 cases (1980–2005). J Am Vet Med Assoc 232(2):237–243. doi:10.2460/javma.232.2.237

    Article  PubMed  Google Scholar 

  • Matus RE, Leifer CE, MacEwen EG (1983) Acute lymphoblastic leukemia in the dog: a review of 30 cases. J Am Vet Med Assoc 183(8):859–862

    CAS  PubMed  Google Scholar 

  • Matus RE, Leifer CE, MacEwen EG, Hurvitz AI (1986) Prognostic factors for multiple myelomas in the dog. J Am Vet Med Assoc 188(11):1288–1292

    CAS  PubMed  Google Scholar 

  • Meis JM, Butler JJ, Osborne BM, Ordonez NG (1987) Solitary plasmacytomas of bone and extramedullary plasmacytomas. A clinicopathologic and immunohistochemical study Cancer.59(8):1475–1485

    CAS  PubMed  Google Scholar 

  • Meleo KA (1997) The role of radiotherapy in the treatment of lymphoma und thymoma. Vet Clin North Am Small Anim Pract 27(1):115–129

    Article  CAS  PubMed  Google Scholar 

  • Mellor PJ, Haugland S, Murphy S, Smith KC, Holloway A, Archer J, Powell RM, Polton GA, Tasker S, McCormick D, Tempest ME, McNeil PE, Scase TJ, Knott CD, Bonfanti U, Villiers EJ, Argyle DJ, Herrtage ME, Day MJ (2006) Myelomas-related disorders in cats commonly present as extramedullary neoplasms in contrast to myelomas in human patients: 24 cases with clinical follow-up. J Vet Intern Med 20(6):1376–1383

    Article  PubMed  Google Scholar 

  • Mellor PJ, Haugland S, Smith KC, Powell RM, Archer J, Scase TJ, Villiers EJ, McNeil PE, Nixon C, Knott C, Fournier D, Murphy S, Polton GA, Belford C, Philbey AW, Argyle DJ, Herrtage ME, Day MJ (2008) Histopathologic, immunohistochemical, and cytologic analysis of feline myelomas-related disorders: further evidence for primary extramedullary development in the cat. Vet Pathol Online 45(2):159–173. 10.1354/vp.45-2-159

    Article  CAS  Google Scholar 

  • Messick JB (2013) The lymph nodes. In: Cowell RL, Valenciano AC (Hrsg) Cowell and Tyler’s diagnostic cytology and hematology of the dog and cat, 4. Aufl. Elsevier, St. Louis, S 180–194

    Google Scholar 

  • Milner RJ, Peyton J, Cooke K, Fox LE, Gallagher A, Gordon P, Hester J (2005) Response rates und survival times for cats with lymphoma treated with the University of Wisconsin-Madison chemotherapy protocol: 38 cases (1996–2003). J Am Vet Med Assoc 227(7):1118–1122

    Article  PubMed  Google Scholar 

  • Mooney SC, Hayes AA (1986) Lymphomas in the cat: an approach to diagnosis and management. Semin Vet Med Surg (Small Anim) 1(1):51–57

    CAS  Google Scholar 

  • Mooney SC, Hayes AA, Matus RE, MacEwen EG (1987) Renal lymphoma in cats: 28 cases (1977–1984). J Am Vet Med Assoc 191(11):1473–1477

    CAS  PubMed  Google Scholar 

  • Mooney SC, Hayes AA, MacEwen EG, Matus RE, Geary A, Shurgot BA (1989) Treatment and prognostic factors in lymphoma in cats: 103 cases (1977–1981). J Am Vet Med Assoc 194(5):696–702

    CAS  PubMed  Google Scholar 

  • Moore PF (2014) A review of histiocytic diseases of dogs and cats. Vet Pathol 51(1):167–184. 10.1177/0300985813510413

    Article  CAS  PubMed  Google Scholar 

  • Moore PF, Affolter VK, Vernau W (2006) Canine hemophagocytic histiocytic sarcomas: a proliferative disorder of CD11d + macrophages. Vet Pathol 43(5):632–645. 10.1354/vp.43-5-632.

    Article  CAS  PubMed  Google Scholar 

  • Morris JS, Dunn JK, Dobson JM (1993) Canine lymphoid leukaemia and lymphomas with bone marrow involvement: a review of 24 cases. J Small Anim Pract 34(2):72–79. 10.1111/j.1748-5827.1993.tb02613.x

    Article  Google Scholar 

  • Mortier F, Daminet S, Vandenabeele S, Van De Maele I (2012) Canine lymphomas: a retrospective study (2009–2010). Vlaams Diergeneeskundig Tijdschrift 81(6):341–351

    Google Scholar 

  • Novacco M, Comazzi S, Marconato L, Cozzi M, Stefanello D, Aresu L, Martini V (2015) Prognostic factors in canine acute leukaemias: a retrospective study. Vet Comp Oncol:n/a-n/a. doi:10.1111/vco.12136

    Google Scholar 

  • Osborne CA, Perman V, Sautter JH, Stevens JB, Hanlon GF (1968) Multiple myelomas in the dog. J Am Vet Med Assoc 153(10):1300–1319

    CAS  PubMed  Google Scholar 

  • Owen LN (1980) TNM classification of tumours in domestic animals. World Health Organization, Geneva

    Google Scholar 

  • Padgett GA, Madewell BR, Keller ET, Jodar L, Packard M (1995) Inheritance of histiocytosis in Bernese mountain dogs. J Small Anim Pract 36(3):93–98

    Article  CAS  PubMed  Google Scholar 

  • Patel RT, Caceres A, French AF, McManus PM (2005) Multiple myelomas in 16 cats: a retrospective study. Vet Clin Pathol 34(4):341–352

    Article  PubMed  Google Scholar 

  • Platz SJ, Breuer W, Pfleghaar S, Minkus G, Hermanns W (1999) Prognostic value of histopathological grading in canine extramedullary plasmacytomas. Vet Pathol 36(1):23–27

    Article  CAS  PubMed  Google Scholar 

  • Ragaini L, Aste G, Cavicchioli L, Boari A (2003) Inflammatory bowel disease mimicking alimentary lymphosarcomas in a cat. Vet Res Commun 27(Suppl 1):791–793

    Article  PubMed  Google Scholar 

  • Reinacher M, Theilen G (1987) Frequency und significance of feline leukemia virus infection in necropsied cats. Am J Vet Res 48(6):939–945

    CAS  PubMed  Google Scholar 

  • Richards KL, Suter SE (2015) Man’s best friend: what can pet dogs teach us about non-Hodgkin’s lymphomas?. Immunol Rev 263(1):173–191. 10.1111/Imr.12238

    Article  PubMed  PubMed Central  Google Scholar 

  • Rusbridge C, Wheeler SJ, Lamb CR, Page RL, Carmichael S, Brearley MJ, Bjornson AP (1999) Vertebral plasma cell tumors in 8 dogs. J Vet Intern Med 13(2):126–133

    Article  CAS  PubMed  Google Scholar 

  • Sato H, Fujino Y, Chino J, Takahashi M, Fukushima K, Goto-Koshino Y, Uchida K, Ohno K, Tsujimoto H (2014) Prognostic Analyses on Anatomical und Morphological Classification of Feline Lymphoma. J Vet Med Sci 76(6):807–811. doi:10.1292/jvms.13-0260.

    Article  PubMed  PubMed Central  Google Scholar 

  • Savary KC, Price GS, Vaden SL (2000) Hypercalcemia in cats: a retrospective study of 71 cases (1991–1997). J Vet Intern Med 14(2):184–189

    CAS  PubMed  Google Scholar 

  • Shearin AL, Hedan B, Cadieu E, Erich SA, Schmidt EV, Faden DL, Cullen J, Abadie J, Kwon EM, Grone A, Devauchelle P, Rimbault M, Karyadi DM, Lynch M, Galibert F, Breen M, Rutteman GR, Undre C, Parker HG, Ostrunder EA (2012) The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research. cosponsored by the American Society of Preventive Oncology 21(7):1019–1027. doi:10.1158/1055-9965.EPI-12-0190-T

    CAS  Google Scholar 

  • Simon D, Eberle N, Laacke-Singer L, Nolte I (2008) Combination chemotherapy in feline lymphoma: treatment outcome, tolerability, und duration in 23 cats. J Vet Intern Med 22(2):394–400. doi:10.1111/j.1939-1676.2008.0057.x

    Article  CAS  PubMed  Google Scholar 

  • Taylor SS, Goodfellow MR, Browne WJ, Walding B, Murphy S, Tzannes S, Gerou-Ferriani M, Schwartz A, Dobson JM (2009) Feline extranodal lymphoma: response to chemotherapy und survival in 110 cats. J Small Anim Pract 50(11):584–592. doi:10.1111/j.1748-5827.2009.00813.x

    Article  CAS  PubMed  Google Scholar 

  • Teske E, Van Heerde P, Rutteman GR, Kurzman ID, Moore PF, MacEwen EG (1994) Prognostic factors for treatment of malignant lymphoma in dogs. J Am Vet Med Assoc 205(12):1722–1728

    CAS  PubMed  Google Scholar 

  • Troxel MT, Vite CH, Van Winkle TJ, Newton AL, Tiches D, Dayrell-Hart B, Kapatkin AS, Shofer FS, Steinberg SA (2003) Feline intracranial neoplasia: retrospective review of 160 cases (1985–2001). J Vet Intern Med 17(6):850–859

    PubMed  Google Scholar 

  • Vail DM, Kisseberth WC, Obradovich JE, Moore FM, London CA, MacEwen EG, Ritter MA (1996) Assessment of potential doubling time (Tpot). argyrophilic nucleolar organizer regions (AgNOR), and proliferating cell nuclear antigen (PCNA) as predictors of therapy response in canine non-Hodgkin’s Lymphome. Exp Hematol 24(7):807–815

    CAS  Google Scholar 

  • Vail DM, Moore AS, Ogilvie GK, Volk LM (1998) Feline lymphomas (145 cases): proliferation indices, cluster of differentiation 3 immunoreactivity, and their association with prognosis in 90 cats. J Vet Intern Med 12(5):349–354

    Article  CAS  PubMed  Google Scholar 

  • Valli VE (2007) Veterinary comparative hematopathology. Blackwell, Ames.

    Book  Google Scholar 

  • Valli VE, Jacobs RM, Parodi AL, Vernau W, Moore PF (2002) World Health Organization International Histological classification of tumors of domestic animals: Histological classification of hematopoietic tumors of domestic animals, Vol. VIII. Second Series. Armed Force Institut of Pathology, American Registry of Pathology, Washington, DC

    Google Scholar 

  • Valli VE, San Myint M, Barthel A, Bienzle D, Caswell J, Colbatzky F, Durham A, Ehrhart EJ, Johnson Y, Jones C, Kiupel M, Labelle P, Lester S, Miller M, Moore P, Moroff S, Roccabianca P, Ramos-Vara J, Ross A, Scase T, Tvedten H, Vernau W (2011) Classification of canine malignant lymphomas according to the World Health Organization criteria. Vet Pathol 48(1):198–211. 10.1177/0300985810379428

    Article  CAS  PubMed  Google Scholar 

  • Valli VE, Kass PH, San Myint M, Scott F (2013) Canine lymphomas: association of classification type, disease stage, tumor subtype, mitotic rate, and treatment with survival. VetPathol 50(5):738–748. Doi:10.1177/0300985813478210

    CAS  Google Scholar 

  • Workman HC, Vernau W (2003) Chronic lymphocytic leukemia in dogs and cats: the veterinary perspective. Vete Clin North Am Small Anim Pract 33(6):1379–1399

    Article  Google Scholar 

  • Wright ZM, Rogers KS, Mansell J (2008) Survival data for Canine oral extramedullary plasmacytomes: a retrospective analysis (1996–2006). J Am Anim Hosp Assoc 44(2):75–81. doi:10.5326/0440075

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag GmbH Deutschland

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Henrich, M. (2017). Hämatopoetische Tumoren. In: Klopfleisch, R. (eds) Veterinäronkologie kompakt. Springer Spektrum, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54987-2_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-54987-2_6

  • Published:

  • Publisher Name: Springer Spektrum, Berlin, Heidelberg

  • Print ISBN: 978-3-662-54986-5

  • Online ISBN: 978-3-662-54987-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics