Skip to main content
SpringerLink
Log in

Overview of Clinical Experience with Ciprofloxacin

  • Chapter
Ciprofloxacin

Part of the book series: Current Topics in Infectious Diseases and Clinical Microbiology ((CTIDCM,volume 1))

Abstract

Ciprofloxacin is a new 4-quinolone antibacterial agent with an extended antibacterial spectrum, enhanced potency and the ability to produce therapeutic serum, tissue and urine concentrations after oral administration. Unlike earlier 4-quinolones, it is active against gram-positive cocci and opportunistic organisms such as Pseudomonas aeruginosa. This overview demonstrates that the oral formulation has been shown to be clinically effective in a broad range of urinary and respiratory infections, gonorrhoea, gastro-intestinal infections including typhoid fever, surgical infections, skin and soft tissue sepsis and in a variety of infections caused by Pseudomonas aeruginosa, notably cystic fibrosis. Adverse reactions are infrequent and in almost every case have proved mild and transient. Ciprofloxacin has great potential for the oral therapy of infections which have traditionally required parenteral chemotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ball, A. P., Reeves, D. S.: Clinical experience with piperazinyl substituted 4-quinolones. Quinolones Bulletin 1985, 2: 4 - 5.

    Google Scholar 

  2. Smith, J. T.: Awakening the slumbering potential of the 4-quinolone antibacterials. Pharmaceutical Journal 1984, 229 - 305.

    Google Scholar 

  3. Reeves, D. S., Bywater, M. J., Holt, H. A., White, L. O.: In vitro studies with ciprofloxacin, a new 4-quinolone compound. Journal of Antimicrobial Chemotherapy 1984, 13: 333 - 346.

    Article  CAS  PubMed  Google Scholar 

  4. Reeves, D. S., Bywater, M. J., Holt, H. A.: The activity of enoxacin against clinical bacterial isolates in cornparison with that of five other agents, and factors affecting that activity. Journal of Antimicrobial Chemotherapy 1984, 14 Supplement C: 7-17.

    Google Scholar 

  5. Clarke, A. M., Zemcov, S. J. V., Campbell, M. E.: In vitro activity of pefloxacin compared to enoxacin, norfloxacin, gentamicin and new beta-lactams. Journal of Antimicrobial Chemotherapy 1985, 15: 39 - 44.

    Article  CAS  PubMed  Google Scholar 

  6. Cullmann, W., Stieglitz, M., Baars, B., Opferkuch, W.: Comparative evaluation of recently developed quinolone compounds — with a note on the frequency of resistant mutants. Chemotherapy 1985, 31: 19 - 28.

    Article  CAS  PubMed  Google Scholar 

  7. Fass, R. J.: In vitro activity of ciprofloxacin (Bay 09867). Antimicrobial Agents and Chemotherapy 1983, 24: 568 - 574.

    Article  CAS  PubMed  Google Scholar 

  8. King, A., Shannon, K., Phillips, I.: The in vitro activity of ciprofloxacin compared with that of norfloxacin and nalidixic acid. Journal of Antimicrobial Chemotherapy 1984, 13: 325 - 331.

    Article  CAS  PubMed  Google Scholar 

  9. Wise, R., Andrews, J. M., Bedford, L.J.: In vitro activity of Bay 09867, a new quinolone derivative, compared with those of other antimicrobial agents. Antimicrobial Agents and Chemotherapy 1983, 23: 559 - 564.

    Article  CAS  PubMed  Google Scholar 

  10. Greenwood, D., Laverick, A.: Activities of newer quinolones against legionella group organisms. Lancet 1983, is 279-280.

    Google Scholar 

  11. Chin, N.-X., Neu, H. C.: Ciprofloxacin: a quinolonecarboxylic acid active against aerobic and anaerobic bacteria. Antimicrobial Agents and Chemotherapy 1984, 25: 319 - 326.

    Article  CAS  PubMed  Google Scholar 

  12. Ridgway, G. L., Mumtaz, G., Gabriel, F. G., Oriel, J. D.: The activity of ciprofloxacin and other 4-quinolones against Chlamydia trachomatis and mycoplasmas in vitro. European Journal of Clinical Microbiology 1984, 3: 344 - 346.

    Article  CAS  PubMed  Google Scholar 

  13. Hoffken, G., Lode, H., Prinzing, C., Borner, K., Koeppe, P.: Pharmacokinetics of ciprofloxacin after oral and parenteral administration. Antimicrobial Agents and Chemotherapy 1985, 27: 375 —379.

    Google Scholar 

  14. Ledergerber, B., Bettex, J-D., Joos, B., Flepp, M., Luthy, R.: Effect of standard breakfast on drug absorption and multiple-dose pharmacokinetics of ciprofloxacin. Antimicrobial Agents and Chemotherapy 1985, 27: 350 - 352.

    Article  CAS  PubMed  Google Scholar 

  15. Hoffken, G., Borner, K., Glatzel, P. D., Koeppe, P., Lode, H.: Reduced enteral absorption of ciprofloxacin in the presence of antacids. European Journal of Clinical Microbiology 1985, 4: 345.

    Article  CAS  PubMed  Google Scholar 

  16. Bergan, T., Dalhoff, A., Thorsteinsson, S. B.: A review of the pharmacokinetics and tissue penetration of ciprofloxacin. In: Ciprofloxacin: a new 4-quinolone. Sieber and McIntyre Inc. Hongkong, 1985, p. 23 - 36.

    Google Scholar 

  17. Ball, A. P., Fox, C., Ball, M. E., Brown, I. R. F., Willis, J. V.: Pharmacokinetics of oral ciprofloxacin, 100 mg single dose, in volunteers and elderly patients. Journal of Antimicrobial Chemotherapy 1986, 17.

    Google Scholar 

  18. Joos, B., Ledergerber, B., Flepp, M., Bettex, J-D., Luthy, R., Siegenthaler, W.: Comparison of high-pressure liquid chromatography and bioassay for determination of ciprofloxacin in serum and urine. Antimicrobial Agents and Chemotherapy 1985, 27: 353 - 356.

    Article  CAS  PubMed  Google Scholar 

  19. Boelaert, J., Valcke, Y., Schurgers, M., Daneels, R., Rosseneu, M., Rosseel, M. T., Bogaert, M. G.: The pharmacokinetics of ciproflxoacin in patients with impaired renal function. Journal of Antimicrobial Chemotherapy 1985, 16: 87 —93.

    Google Scholar 

  20. Boerema, J. B. J., Dalhoff, A., Debruyne, F. M. Y.: Ciprofloxacin distribution in prostatic tissue and fluid after oral administration. Chemotherapy 1985, 31: 13 - 18.

    Article  CAS  PubMed  Google Scholar 

  21. Brogard, J.-M., Jehl, F., Monteil, H., Adloff, M., Blickle, J.-F., Levy, P.: Comparison of high-pressure liquid chromatography and microbiological assay for the determination of biliary elimination of ciprofloxacin in humans. Antimicrobial Agents and Chemotherapy 1985, 28: 311 - 314.

    Article  CAS  PubMed  Google Scholar 

  22. Goormans, E., Dalhoff, A., Kazzaz, B., Branolte, J.: Penetration of ciprofloxacin into gynaecological tissues following oral and intravenous administration. Chemotherapy 1986, 32: 7 - 17.

    Article  CAS  PubMed  Google Scholar 

  23. Bergogne-Berezin, E., Berthelot, G., Even P., Stern, M., Reynaud, P.: Penetration of ciprofloxacin into bronchial secretions. European Journal of Clinical microbiology 1986, 5: 197 - 200.

    Article  CAS  PubMed  Google Scholar 

  24. Wise, R., Lockley, M. R., Crump, B., Adhami, Z. N.: The pharmacokinetics and tissue penetration of orally administered enoxacin, norfloxacin and ciprofloxacin. Research and Clinical Forums 1985, 7: 63 - 68.

    CAS  Google Scholar 

  25. Giamarellou, H., Efstratiou, A., Tsagarakis, J., Petrikkos, G., Daikos, G. K.: Experience with ciprofloxacin in vitro and in vivo. Arzneimittel-Forschung 1984, 34: 1175 - 1178.

    Google Scholar 

  26. Giamarellou, H., Daphnis, E., Dendrinos, C., Daikos, G. K.: Experience with ciprofloxacin in the treatment of various infections caused mainly by Pseudomonas aeruginosa. Drugs under Experimental and Clinical Research 1985, 11: 351 - 356.

    CAS  PubMed  Google Scholar 

  27. Mehtar, S., Drabu, Y., Blakemore, P.: Ciprofloxacin in the treatment of infections caused by gentamicinresistant gram-negative bacteria. European Journal of Clinical Microbiology 1986, 5: 248 - 251.

    Article  CAS  PubMed  Google Scholar 

  28. Van Poppel, H., Wegge, M., Dammekens, H., Chysky, V.: Oral treatment of pseudomonas-induced urinary tract infections with ciprofloxacin. Chemotherapy 1986, 32: 83 - 87.

    Article  PubMed  Google Scholar 

  29. Naber, K., Bartosik-Wich, B.: Therapie komplizierter Harnwegsinfektionen mit norfloxacin versus ciprofloxacin. Fortschritte der antimikrobiellen and tinti-neoplastischen Chemotherapie 1984, 3-5: 749 - 758.

    Google Scholar 

  30. Tegelberg-Stassen, M. J. A. M., van der Hoek, J. C. S., Mooi, L., Wagenvoort, J. H. T., van Joost, T., Michel,M. F., Stolz, E.: Treatment of uncomplicated gonococcal urethritis in men with two dosages of ciprofloxacin. European Journal of Clinical Microbiology 1986, 5: 244 - 246.

    Google Scholar 

  31. Loo, P. S., Ridgway, G. L., Oriel, J. D.: Single dose ciprofloxacin for treating gonococcal infections in men. Genitourinary Medicine 1985, 61: 302 - 305.

    CAS  PubMed  Google Scholar 

  32. Yamaguchi, K., Hara, K.: Clinical evaluation of Bay 09867 in the field of internal medicine in Japan. In: Ciprofloxacin: a new 4-quinolone. Sieber and McIntyre, Hongkong, 1985, 47 - 53.

    Google Scholar 

  33. Davies, B. I., Maesen, F. P. V., Baur, C.: Ciprofloxacin in the treatment of acute exacerbations of chronic bronchitis. European Journal of Clinical Microbiology 1986, 5: 226 - 231.

    Article  CAS  PubMed  Google Scholar 

  34. Schacht, P., Bruck, H., Chysky, V., Huffman, R., Weuta, H., Arcieri, G., Branolte, J., Konopka, C., Papachristou, C., Westwood, A.: Overall clinical results with ciprofloxacin. In: Ciprofloxacin: a new 4-quinolone. Sieber and McIntyre. Hongkong, 1985, 81 - 88.

    Google Scholar 

  35. Shah, P. M.: Ciprofloxacin in the treatment of cystic fibrosis. Quinolones Bulletin 1984, 1: 6.

    Google Scholar 

  36. Sanford, J. P., Linh, N. N., Kutscher, E., Arnold, K., Gould, K.: Oxolinic acid in the treatment of typhoid fever due to chloramphenicol-resistant strains of Salmonella typhi. Antimicrobial Agents and Chemotherapy 1976, 9: 387 - 390.

    Article  CAS  PubMed  Google Scholar 

  37. Ramirez, C., Bran, J. L., Mejia, C. R., Garcia, J. F.: Open prospective study of the clinical efficacy of ciprofloxacin. Antimicrobial Agents and Chemotherapy 1985, 28: 128 - 132.

    Article  CAS  PubMed  Google Scholar 

  38. Arcieri, G., August, R., Becker, N., Doyle, C., Griffith, E., Gruenwaldt, G., Heyd, A., O’Brien, B.: Clinical experience with ciprofloxacin in the USA. European Journal of Clinical Microbiology 1986, 5: 220 - 225.

    Article  CAS  PubMed  Google Scholar 

  39. Follath, F., Bindschelder, M., Wenk, M., Frei, R., Stalder, H., Reber, H.: Use of ciprofloxacin in the treatment of Pseudomonas aeruginosa infections. European Journal of Clinical Microbiology 1986, 5: 236 - 240.

    Article  CAS  PubMed  Google Scholar 

  40. Eron, L. J., Harvey, L., Hixon, D. L., Poretz, D. M.: Ciprofloxacin therapy of infections caused by Pseudomonas aeruginosa and other resistant bacteria. Antimicrobial Agents and Chemotherapy 1985, 27: 308 - 310.

    Article  Google Scholar 

  41. Baba, S.: Clinical evaluation of Bay 09867 in the fields of surgery, obstetrics and gynaecology, dermatology, otorhinolaryngology and ophthalmology. In: Ciprofloxacin: a new 4-quinolone. Sieber and McIntyre. Hongkong, 1985, 71 - 79.

    Google Scholar 

  42. Kobayashi, H.: Summary of clinical studies on ciprofloxacin. In: Ciprofloxacin: a new 4-quinolone. Sieber and McIntyre. Hongkong, 1985, 85 - 88.

    Google Scholar 

  43. Maesen, F. P. V., Teengs, J. P., Baur, C., Davies, B. I.: Quinolones and raised plasma concentrations of theophylline. Lancet 1984, ii: 530.

    Google Scholar 

  44. Wiinands, W. J. A., van Heerwarden, C. L. A., Vree, T. B.: Enoxacin raises plasma theophylline concentrations. Lancet 1984, is 108-109.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Infectious Diseases Unit, Cameron Hospital, KY8 5RR, Windygates, Fife, UK

    A. P. Ball

Authors
  1. A. P. Ball
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

H. C. Neu D. S. Reeves

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer Fachmedien Wiesbaden

About this chapter

Cite this chapter

Ball, A.P. (1986). Overview of Clinical Experience with Ciprofloxacin. In: Neu, H.C., Reeves, D.S. (eds) Ciprofloxacin. Current Topics in Infectious Diseases and Clinical Microbiology, vol 1. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-01930-5_27

Download citation

  • DOI: https://doi.org/10.1007/978-3-663-01930-5_27

  • Publisher Name: Vieweg+Teubner Verlag, Wiesbaden

  • Print ISBN: 978-3-663-01931-2

  • Online ISBN: 978-3-663-01930-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation