Abstract
Solubility is a key property influencing behavior of compounds in nature, science, biomedical applications, etc. Hydrophobicity and poor solubility of drugs and other bioactive compounds limit their possible applications in drug delivery and formulation development. Therefore approximately 40 % of newly developed drugs are rejected by the pharmaceutical industry and will never benefit a patient owing to poor bioavailability due to low water solubility and/or cell membrane permeability. In most cases, this problem can be solved by dendrimers. Many examples of dendrimers with different cores, branches, structures, hydrophilic surface groups, and hydrophobic pockets are described, including PEGylated dendrimers. The application of dendrimers as solubility enhancers for many drugs, such as anticancer drugs, antidepressants, antifungal drugs, antihemorrhagic drugs, antihistaminics, anti-inflammatory drugs, and antimicrobial drugs, is discussed. Solubility is in close relation with delivery, bioavailability, and/or cell membrane permeability; therefore see also these chapters.
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Šebestík, J., Reiniš, M., Ježek, J. (2012). Dendrimers and Solubility. In: Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1206-9_10
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DOI: https://doi.org/10.1007/978-3-7091-1206-9_10
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