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Restorative Strategies for the Dopaminergic Nigrostriatal Projection Pathway

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Stereotactic and Functional Neurosurgery

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 117))

Abstract

New insights into the mechanism of dopaminergic (DA) nigrostriatal neuron degeneration and regeneration in experimental studies in animal models of Parkinson’s disease (PD) have opened up the discussion about novel therapeutic strategies such as cell-based therapies and neuroprotection of DA neurons. These cellular and molecular approaches aim at preventing or slowing down the progressive degeneration of DA neurons and/or replacing the lost ones. Here, a brief overview of basic principles and current strategies of these novel restorative approaches is discussed in light of experimental results and possible clinical applications.

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Acknowledgments

Parts of the work presented here have been supported by grants from the Deutsche Forschungsgemeinschaft (Ni 330), the Graduate School Freiburg (DFG 843), the Weber Petri Foundation, the German Parkinson Foundation and the European Commission under the 7th Framework Programme — HEALTH — Collaborative Project Transeuro (Contract n 242003).

Conflict of InterestNo potential conflict of interest relevant to this article was reported.

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Authors and Affiliations

  1. Division of Stereotactic and Functional Neurosurgery, Department of General Neurosurgery, Neurosurgical Clinic, University Medical Center Freiburg, Breisacher Straße 64, Freiburg, D-79106, Germany

    Guido Nikkhah MD, PhD

  2. Neurosurgical Clinic, University Hospital Erlangen, Schwabachanlage 6, Erlangen, D-91054, Germany

    Guido Nikkhah MD, PhD

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  1. Guido Nikkhah MD, PhD
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Correspondence to Guido Nikkhah MD, PhD .

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Editors and Affiliations

  1. , Neurosurgical Clinic, University Hospital Erlangen, Schwabachanlage 6, Erlangen, 91054, Germany

    Guido Nikkhah

  2. Department of Neurosurgery, Division of Stereotactic and Functional, University Medical Center Freiburg, Breisacher Straße 64, Freiburg, 79106, Germany

    Marcus Pinsker

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Nikkhah, G. (2013). Restorative Strategies for the Dopaminergic Nigrostriatal Projection Pathway. In: Nikkhah, G., Pinsker, M. (eds) Stereotactic and Functional Neurosurgery. Acta Neurochirurgica Supplement, vol 117. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1482-7_13

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  • DOI: https://doi.org/10.1007/978-3-7091-1482-7_13

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