Connective Tissue

Abstract

The connective tissue, composed of cells and extracellular matrix, forms a framework designated as stroma, which connects and supports all other tissues of the body. However, it is not only an inert scaffolding to stabilize other tissues and organs, but is dynamic and the site of multiple regulatory processes involved in tissue organization, development, wound healing, immune response, and organ repair. The extracellular matrix is constantly renewed and molecules of the extracellular matrix modulate the functional activities of cells. They also play key roles in disease processes, including inflammatory and degenerative diseases and cancer. The matrix is involved in tumor invasion, metastasis, and tumor angiogenesis.