Summary
The daily urinary excretion of total (R)- and (S)-salsolinol and 1,2-dehydrosalsolinol (free + sulfoconjugate) was measured in patients with degenerative dementia. (R)-Salsolinol was detectable in the urine of 5 out of 12 patients and 1,2-dehydrosalsolinol in the urine of 10 patients, whereas (S)-salsolinol was not detectable. The urinary excretion of 1,2-dehydrosalsolinol appears to be similar in demented and parkinsonian patients, suggesting that the biosynthesis of salsolinol precursors may be similar in the two groups.
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© 1990 Springer-Verlag Wien
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Dostert, P., Benedetti, M.S., Bellotti, V., Dordain, G., Vernay, D., Deffond, D. (1990). Urinary excretion of salsolinol enantiomers and 1,2-dehydrosalsolinol in patients with degenerative dementia. In: Maurer, K., Riederer, P., Beckmann, H. (eds) Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3396-5_38
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DOI: https://doi.org/10.1007/978-3-7091-3396-5_38
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82197-8
Online ISBN: 978-3-7091-3396-5
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